ICMT — 32 ClinVar variants
All ClinVar germline ICMT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 31 Uncertain significance
Full ICMT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ICMT p.Ala176Val Uncertain significance Single submitter
- ICMT p.Ala19Ser Uncertain significance Single submitter
- ICMT p.Ala2Glu Uncertain significance Single submitter
- ICMT p.Ala2Ser Uncertain significance Single submitter
- ICMT p.Ala36Thr Uncertain significance Single submitter
- ICMT p.Ala6Ser Uncertain significance Single submitter
- ICMT p.Arg209Gln Uncertain significance Single submitter
- ICMT p.Arg242Gln Uncertain significance Single submitter
- ICMT p.Arg63His Uncertain significance Single submitter
- ICMT p.Cys228Trp Uncertain significance Single submitter
- ICMT p.Cys4Ser Uncertain significance Single submitter
- ICMT p.Glu261Lys Uncertain significance Single submitter
- ICMT p.Gly11Val Uncertain significance Single submitter
- ICMT p.Gly40Ser Uncertain significance Single submitter
- ICMT p.His257Tyr Uncertain significance Single submitter
- ICMT p.Ile148Thr Uncertain significance Single submitter
- ICMT p.Ile277Val Uncertain significance Single submitter
- ICMT p.Leu18Phe Uncertain significance Single submitter
- ICMT p.Leu238Val Uncertain significance Single submitter
- ICMT p.Leu32Pro Uncertain significance Single submitter
- ICMT p.Lys278Asn Uncertain significance Single submitter
- ICMT p.Phe179Leu Uncertain significance Single submitter
- ICMT p.Pro9Leu Uncertain significance Single submitter
- ICMT p.Ser138Ala Uncertain significance Single submitter
- ICMT p.Trp150Cys Uncertain significance Single submitter
- ICMT p.Tyr59Cys Uncertain significance Single submitter
- ICMT p.Val200Gly Uncertain significance Single submitter
- ICMT p.Val282Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ICMT variants
Benign 1
- p.Val188= Multiple submitters
Uncertain significance 31
- p.Ala176Val Single submitter ⚠
- p.Ala19Ser Single submitter ⚠
- p.Ala2Glu Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala36Thr Single submitter ⚠
- p.Ala6Ser Single submitter ⚠
- p.Arg209Gln Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Asp246Tyr Single submitter
- p.Cys228Trp Single submitter ⚠
- p.Cys4Ser Single submitter ⚠
- p.Glu261Lys Single submitter ⚠
- p.Gly11Val Single submitter ⚠
- p.Gly40Ser Single submitter ⚠
- p.His257Tyr Single submitter ⚠
- p.Ile148Thr Single submitter ⚠
- p.Ile277Val Single submitter ⚠
- p.Leu18Phe Single submitter ⚠
- p.Leu238Val Single submitter ⚠
- p.Leu32Pro Single submitter ⚠
- p.Lys278Asn Single submitter ⚠
- p.Met97Thr Single submitter ⚠
- p.Phe179Leu Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Ser138Ala Single submitter ⚠
- p.Trp150Cys Single submitter ⚠
- p.Tyr59Cys Single submitter ⚠
- p.Val200Gly Single submitter ⚠
- p.Val225Met Single submitter ⚠
- p.Val282Met Single submitter ⚠