Sugi Variant

Sugi Variant/IDH1

IDH1 — 454 ClinVar variants

All ClinVar germline IDH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 262 flagged for review →

2 Pathogenic · 2 Pathogenic/Likely pathogenic · 2 Likely pathogenic · 20 Benign · 1 Benign/Likely benign · 152 Likely benign · 275 Uncertain significance

Full IDH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 262

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 198

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 198

Predictors split 63

The independent predictors disagree with each other — read with care.

All IDH1 variants

Pathogenic 2

Pathogenic/Likely pathogenic 2

Likely pathogenic 2

Benign 20

Benign/Likely benign 1

Likely benign 152

Uncertain significance 275