Sugi Variant

Sugi Variant/IDH3A

IDH3A — 314 ClinVar variants

All ClinVar germline IDH3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →

12 Pathogenic · 7 Likely pathogenic · 8 Conflicting · 18 Benign · 5 Benign/Likely benign · 142 Likely benign · 122 Uncertain significance

Full IDH3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 103

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 73

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 25

The independent predictors disagree with each other — read with care.

All IDH3A variants

Pathogenic 12

Likely pathogenic 7

Conflicting classifications of pathogenicity 8

Benign 18

Benign/Likely benign 5

Likely benign 142

Uncertain significance 122