IDO1 — 57 ClinVar variants
All ClinVar germline IDO1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Benign · 4 Likely benign · 50 Uncertain significance
Full IDO1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IDO1 p.Ala204Ser Uncertain significance Single submitter
- IDO1 p.Ala326Gly Uncertain significance Single submitter
- IDO1 p.Ala334Thr Uncertain significance Single submitter
- IDO1 p.Ala358Thr Uncertain significance Single submitter
- IDO1 p.Arg155His Uncertain significance Single submitter
- IDO1 p.Arg193Pro Uncertain significance Single submitter
- IDO1 p.Arg193Trp Uncertain significance Single submitter
- IDO1 p.Arg329Trp Uncertain significance Single submitter
- IDO1 p.Arg77Cys Uncertain significance Single submitter
- IDO1 p.Asp274Gly Uncertain significance Single submitter
- IDO1 p.Asp98His Uncertain significance Single submitter
- IDO1 p.Cys206Tyr Uncertain significance Single submitter
- IDO1 p.Gln76Lys Uncertain significance Single submitter
- IDO1 p.Gly162Arg Uncertain significance Single submitter
- IDO1 p.Gly246Ser Uncertain significance Single submitter
- IDO1 p.Gly251Val Uncertain significance Single submitter
- IDO1 p.Gly324Ala Uncertain significance Single submitter
- IDO1 p.Gly95Ser Uncertain significance Single submitter
- IDO1 p.Leu124Phe Uncertain significance Single submitter
- IDO1 p.Lys61Gln Uncertain significance Single submitter
- IDO1 p.Met5Val Uncertain significance Single submitter
- IDO1 p.Phe185Leu Uncertain significance Single submitter
- IDO1 p.Pro28Ser Uncertain significance Single submitter
- IDO1 p.Ser263Arg Uncertain significance Single submitter
- IDO1 p.Ser8Phe Uncertain significance Single submitter
- IDO1 p.Thr144Ala Uncertain significance Single submitter
- IDO1 p.Tyr111Asp Uncertain significance Single submitter
- IDO1 p.Tyr145Cys Uncertain significance Single submitter
- IDO1 p.Val213Ala Uncertain significance Single submitter
- IDO1 p.Val275Ile Uncertain significance Single submitter
- IDO1 p.Val320Asp Uncertain significance Single submitter
- IDO1 p.Val350Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- IDO1 p.Pro142Leu Benign Multiple submitters
- IDO1 p.Ala199Pro Uncertain significance Single submitter
- IDO1 p.Arg317Gly Uncertain significance Single submitter
- IDO1 p.Arg317His Uncertain significance Single submitter
- IDO1 p.Asp333Glu Uncertain significance Single submitter
- IDO1 p.Cys272Tyr Uncertain significance Single submitter
- IDO1 p.Gly251Glu Uncertain significance Single submitter
- IDO1 p.His45Pro Uncertain significance Single submitter
- IDO1 p.Met88Ile Uncertain significance Single submitter
- IDO1 p.Phe152Leu Uncertain significance Single submitter
- IDO1 p.Pro121Leu Uncertain significance Single submitter
- IDO1 p.Pro142Thr Uncertain significance Single submitter
- IDO1 p.Ser52Tyr Uncertain significance Single submitter
- IDO1 p.Tyr233His Uncertain significance Single submitter
All IDO1 variants
Benign 3
- p.Ala4Thr Multiple submitters
- p.Glu318= Multiple submitters
- p.Pro142Leu Multiple submitters ⚠
Likely benign 4
- c.708-3T>C Multiple submitters
- p.Arg193Gln Single submitter
- p.Arg329Gln Single submitter
- p.Val150Ile Single submitter
Uncertain significance 50
- p.Ala199Pro Single submitter ⚠
- p.Ala204Ser Single submitter ⚠
- p.Ala326Gly Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala358Thr Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg193Pro Single submitter ⚠
- p.Arg193Trp Single submitter ⚠
- p.Arg317Gly Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Arg329Trp Single submitter ⚠
- p.Arg77Cys Single submitter ⚠
- p.Asp274Gly Single submitter ⚠
- p.Asp333Glu Single submitter ⚠
- p.Asp98His Single submitter ⚠
- p.Cys159Tyr Single submitter
- p.Cys206Tyr Single submitter ⚠
- p.Cys272Tyr Single submitter ⚠
- p.Gln76Lys Single submitter ⚠
- p.Gly162Arg Single submitter ⚠
- p.Gly246Ser Single submitter ⚠
- p.Gly251Glu Single submitter ⚠
- p.Gly251Val Single submitter ⚠
- p.Gly324Ala Single submitter ⚠
- p.Gly95Ser Single submitter ⚠
- p.His45Pro Single submitter ⚠
- p.Ile349Asn Single submitter
- p.Leu124Phe Single submitter ⚠
- p.Leu234Val Single submitter
- p.Leu328Arg Single submitter
- p.Lys137Asn Single submitter
- p.Lys61Gln Single submitter ⚠
- p.Met5Val Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Phe152Leu Single submitter ⚠
- p.Phe185Leu Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro142Thr Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Ser263Arg Single submitter ⚠
- p.Ser52Tyr Single submitter ⚠
- p.Ser8Phe Single submitter ⚠
- p.Thr144Ala Single submitter ⚠
- p.Tyr111Asp Single submitter ⚠
- p.Tyr145Cys Single submitter ⚠
- p.Tyr233His Single submitter ⚠
- p.Val213Ala Single submitter ⚠
- p.Val275Ile Single submitter ⚠
- p.Val320Asp Single submitter ⚠
- p.Val350Met Single submitter ⚠