IDO2 — 68 ClinVar variants
All ClinVar germline IDO2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
3 Benign · 4 Likely benign · 61 Uncertain significance
Full IDO2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IDO2 p.Ala172Ser Uncertain significance Single submitter
- IDO2 p.Ala276Ser Uncertain significance Single submitter
- IDO2 p.Ala276Val Uncertain significance Single submitter
- IDO2 p.Ala339Thr Uncertain significance Single submitter
- IDO2 p.Ala341Gly Uncertain significance Single submitter
- IDO2 p.Ala61Pro Uncertain significance Single submitter
- IDO2 p.Arg406Cys Uncertain significance Single submitter
- IDO2 p.Arg41Gly Uncertain significance Single submitter
- IDO2 p.Arg78Gly Uncertain significance Single submitter
- IDO2 p.Arg78Trp Uncertain significance Single submitter
- IDO2 p.Arg81Leu Uncertain significance Single submitter
- IDO2 p.Asn48Ser Uncertain significance Single submitter
- IDO2 p.Asp228Gly Uncertain significance Single submitter
- IDO2 p.Asp31His Uncertain significance Single submitter
- IDO2 p.Asp379Tyr Uncertain significance Single submitter
- IDO2 p.Asp64Glu Uncertain significance Single submitter
- IDO2 p.Cys336Tyr Uncertain significance Single submitter
- IDO2 p.Glu309Lys Uncertain significance Single submitter
- IDO2 p.Gly26Arg Uncertain significance Single submitter
- IDO2 p.Gly381Asp Uncertain significance Single submitter
- IDO2 p.His20Tyr Uncertain significance Single submitter
- IDO2 p.His77Asn Uncertain significance Single submitter
- IDO2 p.Ile155Val Uncertain significance Single submitter
- IDO2 p.Ile168Met Uncertain significance Single submitter
- IDO2 p.Ile214Leu Uncertain significance Single submitter
- IDO2 p.Leu147Met Uncertain significance Single submitter
- IDO2 p.Leu218Val Uncertain significance Single submitter
- IDO2 p.Leu28Ile Uncertain significance Single submitter
- IDO2 p.Leu370Ile Uncertain significance Single submitter
- IDO2 p.Met1Arg Uncertain significance Single submitter
- IDO2 p.Met296Thr Uncertain significance Single submitter
- IDO2 p.Phe146Leu Uncertain significance Single submitter
- IDO2 p.Pro30Thr Uncertain significance Single submitter
- IDO2 p.Pro373Leu Uncertain significance Single submitter
- IDO2 p.Pro37Ser Uncertain significance Single submitter
- IDO2 p.Pro6Leu Uncertain significance Single submitter
- IDO2 p.Ser393Gly Uncertain significance Single submitter
- IDO2 p.Thr349Ile Uncertain significance Single submitter
- IDO2 p.Thr385Ile Uncertain significance Single submitter
- IDO2 p.Thr91Ile Uncertain significance Single submitter
- IDO2 p.Val394Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All IDO2 variants
Benign 3
- p.Arg235Trp Multiple submitters
- p.Ile127Val Multiple submitters
- p.Tyr346Ter Multiple submitters
Likely benign 4
- p.Arg206Gln Single submitter
- p.Arg380= Single submitter
- p.Asp144Glu Single submitter
- p.Gly145Arg Single submitter
Uncertain significance 61
- p.Ala172Ser Single submitter ⚠
- p.Ala276Ser Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala339Thr Single submitter ⚠
- p.Ala341Gly Single submitter ⚠
- p.Ala61Pro Single submitter ⚠
- p.Arg235Gln Single submitter
- p.Arg344Gln Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg41Gly Single submitter ⚠
- p.Arg78Gly Single submitter ⚠
- p.Arg78Trp Single submitter ⚠
- p.Arg81Leu Single submitter ⚠
- p.Asn151Lys Single submitter
- p.Asn48Ser Single submitter ⚠
- p.Asp228Gly Single submitter ⚠
- p.Asp31His Single submitter ⚠
- p.Asp379Tyr Single submitter ⚠
- p.Asp64Glu Single submitter ⚠
- p.Cys336Tyr Single submitter ⚠
- p.Glu309Lys Single submitter ⚠
- p.Gly161Arg Single submitter
- p.Gly265Ser Single submitter ⚠
- p.Gly266Arg Single submitter
- p.Gly26Ala Single submitter
- p.Gly26Arg Single submitter ⚠
- p.Gly381Asp Single submitter ⚠
- p.His20Tyr Single submitter ⚠
- p.His77Asn Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile168Met Single submitter ⚠
- p.Ile214Leu Single submitter ⚠
- p.Ile54Phe Single submitter
- p.Leu122Phe Single submitter ⚠
- p.Leu147Met Single submitter ⚠
- p.Leu218Val Single submitter ⚠
- p.Leu238Phe Single submitter ⚠
- p.Leu251Met Single submitter
- p.Leu28Ile Single submitter ⚠
- p.Leu370Ile Single submitter ⚠
- p.Leu50His Single submitter
- p.Met1Arg Single submitter ⚠
- p.Met296Thr Single submitter ⚠
- p.Met66Lys Single submitter
- p.Phe146Leu Single submitter ⚠
- p.Phe230Leu Single submitter
- p.Pro227Thr Single submitter
- p.Pro245Leu Single submitter
- p.Pro248His Single submitter
- p.Pro30Thr Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Ser393Gly Single submitter ⚠
- p.Thr349Ile Single submitter ⚠
- p.Thr385Ile Single submitter ⚠
- p.Thr91Ile Single submitter ⚠
- p.Tyr94Asn Single submitter
- p.Tyr94His Single submitter
- p.Val394Ala Single submitter ⚠
- p.Val95Ala Single submitter