Sugi Variant

Sugi Variant/IFNAR2

IFNAR2 — 314 ClinVar variants

All ClinVar germline IFNAR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 139 flagged for review →

7 Pathogenic · 2 Pathogenic/Likely pathogenic · 2 Likely pathogenic · 12 Conflicting · 13 Benign · 6 Benign/Likely benign · 127 Likely benign · 145 Uncertain significance

Full IFNAR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 139

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 118

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All IFNAR2 variants

Pathogenic 7

Pathogenic/Likely pathogenic 2

Likely pathogenic 2

Conflicting classifications of pathogenicity 12

Benign 13

Benign/Likely benign 6

Likely benign 127

Uncertain significance 145