Sugi Variant

Sugi Variant/IFT74

IFT74 — 635 ClinVar variants

All ClinVar germline IFT74 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 252 flagged for review →

33 Pathogenic · 4 Pathogenic/Likely pathogenic · 17 Likely pathogenic · 5 Conflicting · 49 Benign · 4 Benign/Likely benign · 244 Likely benign · 279 Uncertain significance

Full IFT74 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 252

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 210

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 210

Predictors split 38

The independent predictors disagree with each other — read with care.

All IFT74 variants

Pathogenic 33

Pathogenic/Likely pathogenic 4

Likely pathogenic 17

Conflicting classifications of pathogenicity 5

Benign 49

Benign/Likely benign 4

Likely benign 244

Uncertain significance 279