IGF2BP2 — 59 ClinVar variants
All ClinVar germline IGF2BP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
3 Likely benign · 56 Uncertain significance
Full IGF2BP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IGF2BP2 p.Ala103Val Uncertain significance Single submitter
- IGF2BP2 p.Ala16Thr Uncertain significance Single submitter
- IGF2BP2 p.Ala182Thr Uncertain significance Single submitter
- IGF2BP2 p.Ala31Glu Uncertain significance Single submitter
- IGF2BP2 p.Ala394Val Uncertain significance Single submitter
- IGF2BP2 p.Ala512Val Uncertain significance Single submitter
- IGF2BP2 p.Ala594Thr Uncertain significance Single submitter
- IGF2BP2 p.Arg171His Uncertain significance Single submitter
- IGF2BP2 p.Arg177Gln Uncertain significance Single submitter
- IGF2BP2 p.Arg26Lys Uncertain significance Single submitter
- IGF2BP2 p.Arg346His Uncertain significance Single submitter
- IGF2BP2 p.Arg388Cys Uncertain significance Single submitter
- IGF2BP2 p.Arg474Thr Uncertain significance Single submitter
- IGF2BP2 p.Arg573Cys Uncertain significance Single submitter
- IGF2BP2 p.Arg597Leu Uncertain significance Single submitter
- IGF2BP2 p.Asn110Thr Uncertain significance Single submitter
- IGF2BP2 p.Asn361Tyr Uncertain significance Single submitter
- IGF2BP2 p.Asn500Ser Uncertain significance Single submitter
- IGF2BP2 p.Gln224Arg Uncertain significance Single submitter
- IGF2BP2 p.Glu273Lys Uncertain significance Single submitter
- IGF2BP2 p.Glu555Asp Uncertain significance Single submitter
- IGF2BP2 p.Gly142Arg Uncertain significance Single submitter
- IGF2BP2 p.His230Arg Uncertain significance Single submitter
- IGF2BP2 p.His65Gln Uncertain significance Single submitter
- IGF2BP2 p.Ile300Val Uncertain significance Single submitter
- IGF2BP2 p.Ile310Val Uncertain significance Single submitter
- IGF2BP2 p.Ile318Met Uncertain significance Single submitter
- IGF2BP2 p.Ile477Val Uncertain significance Single submitter
- IGF2BP2 p.Ile562Thr Uncertain significance Single submitter
- IGF2BP2 p.Leu199Arg Uncertain significance Single submitter
- IGF2BP2 p.Met353Thr Uncertain significance Single submitter
- IGF2BP2 p.Met475Leu Uncertain significance Single submitter
- IGF2BP2 p.Pro163Leu Uncertain significance Single submitter
- IGF2BP2 p.Pro391Ser Uncertain significance Single submitter
- IGF2BP2 p.Pro482Leu Uncertain significance Single submitter
- IGF2BP2 p.Ser369Asn Uncertain significance Single submitter
- IGF2BP2 p.Ser403Phe Uncertain significance Single submitter
- IGF2BP2 p.Ser74Leu Uncertain significance Single submitter
- IGF2BP2 p.Thr436Ser Uncertain significance Single submitter
- IGF2BP2 p.Thr550Met Uncertain significance Single submitter
- IGF2BP2 p.Tyr148Cys Uncertain significance Single submitter
- IGF2BP2 p.Tyr148His Uncertain significance Single submitter
- IGF2BP2 p.Val122Ile Uncertain significance Single submitter
- IGF2BP2 p.Val380Met Uncertain significance Single submitter
- IGF2BP2 p.Val471Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- IGF2BP2 p.Ala348Thr Uncertain significance Single submitter
- IGF2BP2 p.Ala441Thr Uncertain significance Single submitter
- IGF2BP2 p.Arg547His Uncertain significance Single submitter
-
IGF2BP2 p.Arg573Leu
Uncertain significance
Single submitter
familial juvenile hyperuricemic nephropathy type 1
- IGF2BP2 p.Glu534Lys Uncertain significance Single submitter
- IGF2BP2 p.Leu58Ile Uncertain significance Single submitter
- IGF2BP2 p.Phe204Leu Uncertain significance Single submitter
- IGF2BP2 p.Phe486Leu Uncertain significance Single submitter
- IGF2BP2 p.Tyr154Cys Uncertain significance Single submitter
- IGF2BP2 p.Tyr40His Uncertain significance Single submitter
All IGF2BP2 variants
Likely benign 3
- p.Ile339Val Single submitter
- p.Ile562= Single submitter
- p.Pro481= Single submitter
Uncertain significance 56
- p.Ala103Val Single submitter ⚠
- p.Ala16Thr Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala31Glu Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala441Thr Single submitter ⚠
- p.Ala512Val Single submitter ⚠
- p.Ala594Thr Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg177Gln Single submitter ⚠
- p.Arg26Lys Single submitter ⚠
- p.Arg346His Single submitter ⚠
- p.Arg388Cys Single submitter ⚠
- p.Arg474Thr Single submitter ⚠
- p.Arg547His Single submitter ⚠
- p.Arg573Cys Single submitter ⚠
- p.Arg573Leu Single submitter familial juvenile hyperuricemic nephropathy type 1 ⚠
- p.Arg597Leu Single submitter ⚠
- p.Asn110Thr Single submitter ⚠
- p.Asn361Tyr Single submitter ⚠
- p.Asn500Ser Single submitter ⚠
- p.Gln224Arg Single submitter ⚠
- p.Glu109Gly Single submitter
- p.Glu273Lys Single submitter ⚠
- p.Glu534Lys Single submitter ⚠
- p.Glu555Asp Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.His230Arg Single submitter ⚠
- p.His65Gln Single submitter ⚠
- p.Ile300Val Single submitter ⚠
- p.Ile310Val Single submitter ⚠
- p.Ile318Met Single submitter ⚠
- p.Ile477Val Single submitter ⚠
- p.Ile562Thr Single submitter ⚠
- p.Leu199Arg Single submitter ⚠
- p.Leu58Ile Single submitter ⚠
- p.Met353Thr Single submitter ⚠
- p.Met475Leu Single submitter ⚠
- p.Phe204Leu Single submitter ⚠
- p.Phe486Leu Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro391Ser Single submitter ⚠
- p.Pro482Leu Single submitter ⚠
- p.Ser369Asn Single submitter ⚠
- p.Ser403Phe Single submitter ⚠
- p.Ser74Leu Single submitter ⚠
- p.Thr436Ser Single submitter ⚠
- p.Thr550Met Single submitter ⚠
- p.Tyr148Cys Single submitter ⚠
- p.Tyr148His Single submitter ⚠
- p.Tyr154Cys Single submitter ⚠
- p.Tyr40His Single submitter ⚠
- p.Val122Ile Single submitter ⚠
- p.Val380Met Single submitter ⚠
- p.Val471Ile Single submitter ⚠