Sugi Variant

Sugi Variant/IGF2R

IGF2R — 337 ClinVar variants

All ClinVar germline IGF2R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 265 flagged for review →

2 Pathogenic · 2 Likely pathogenic · 17 Benign · 2 Benign/Likely benign · 33 Likely benign · 281 Uncertain significance

Full IGF2R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 265

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 227

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 227

Predictors split 36

The independent predictors disagree with each other — read with care.

All IGF2R variants

Pathogenic 2

Likely pathogenic 2

Benign 17

Benign/Likely benign 2

Likely benign 33

Uncertain significance 281