IGFBP1 — 38 ClinVar variants
All ClinVar germline IGFBP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
4 Likely benign · 34 Uncertain significance
Full IGFBP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IGFBP1 p.Ala110Asp Uncertain significance Single submitter
- IGFBP1 p.Ala118Glu Uncertain significance Single submitter
- IGFBP1 p.Ala55Ser Uncertain significance Single submitter
- IGFBP1 p.Arg53Pro Uncertain significance Single submitter
- IGFBP1 p.Arg85Cys Uncertain significance Single submitter
- IGFBP1 p.Asp109Gly Uncertain significance Single submitter
- IGFBP1 p.Cys41Tyr Uncertain significance Single submitter
- IGFBP1 p.Cys59Trp Uncertain significance Single submitter
- IGFBP1 p.Glu125Lys Uncertain significance Single submitter
- IGFBP1 p.Gly247Val Uncertain significance Single submitter
- IGFBP1 p.Gly81Val Uncertain significance Single submitter
- IGFBP1 p.Ile178Thr Uncertain significance Single submitter
- IGFBP1 p.Ile245Met Uncertain significance Single submitter
- IGFBP1 p.Met221Thr Uncertain significance Single submitter
- IGFBP1 p.Pro175His Uncertain significance Single submitter
- IGFBP1 p.Pro27Arg Uncertain significance Single submitter
- IGFBP1 p.Ser108Phe Uncertain significance Single submitter
- IGFBP1 p.Ser149Tyr Uncertain significance Single submitter
- IGFBP1 p.Ser161Leu Uncertain significance Single submitter
- IGFBP1 p.Ser242Thr Uncertain significance Single submitter
- IGFBP1 p.Thr127Ala Uncertain significance Single submitter
- IGFBP1 p.Thr130Pro Uncertain significance Single submitter
- IGFBP1 p.Thr157Ile Uncertain significance Single submitter
- IGFBP1 p.Tyr158Cys Uncertain significance Single submitter
- IGFBP1 p.Val184Ile Uncertain significance Single submitter
- IGFBP1 p.Val18Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All IGFBP1 variants
Likely benign 4
- p.Ala74= Single submitter
- p.Gln106Pro Single submitter
- p.Glu196Asp Single submitter
- p.Gly25Ser Single submitter
Uncertain significance 34
- p.Ala110Asp Single submitter ⚠
- p.Ala118Glu Single submitter ⚠
- p.Ala55Ser Single submitter ⚠
- p.Arg53Pro Single submitter ⚠
- p.Arg85Cys Single submitter ⚠
- p.Asp109Gly Single submitter ⚠
- p.Cys41Tyr Single submitter ⚠
- p.Cys59Trp Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Gly247Val Single submitter ⚠
- p.Gly56Ser Single submitter ⚠
- p.Gly68Asp Single submitter
- p.Gly81Val Single submitter ⚠
- p.Ile178Thr Single submitter ⚠
- p.Ile198Thr Single submitter
- p.Ile245Met Single submitter ⚠
- p.Leu40Phe Single submitter ⚠
- p.Met221Thr Single submitter ⚠
- p.Pro175His Single submitter ⚠
- p.Pro243Ala Single submitter ⚠
- p.Pro249Thr Single submitter
- p.Pro27Arg Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Ser108Phe Single submitter ⚠
- p.Ser149Tyr Single submitter ⚠
- p.Ser161Leu Single submitter ⚠
- p.Ser242Thr Single submitter ⚠
- p.Ser47Trp Single submitter ⚠
- p.Thr127Ala Single submitter ⚠
- p.Thr130Pro Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Tyr158Cys Single submitter ⚠
- p.Val184Ile Single submitter ⚠
- p.Val18Leu Single submitter ⚠