IGFBP3 — 38 ClinVar variants
All ClinVar germline IGFBP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
3 Benign · 35 Uncertain significance
Full IGFBP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IGFBP3 p.Ala10Gly Uncertain significance Single submitter
- IGFBP3 p.Ala10Ser Uncertain significance Single submitter
- IGFBP3 p.Ala117Thr Uncertain significance Single submitter
- IGFBP3 p.Ala130Val Uncertain significance Single submitter
- IGFBP3 p.Ala137Val Uncertain significance Single submitter
- IGFBP3 p.Ala47Pro Uncertain significance Single submitter
- IGFBP3 p.Ala4Val Uncertain significance Single submitter
- IGFBP3 p.Ala56Ser Uncertain significance Single submitter
- IGFBP3 p.Arg214Gly Uncertain significance Single submitter
- IGFBP3 p.Arg259Trp Uncertain significance Single submitter
- IGFBP3 p.Arg39His Uncertain significance Single submitter
- IGFBP3 p.Arg93Leu Uncertain significance Single submitter
- IGFBP3 p.Gln198Glu Uncertain significance Single submitter
- IGFBP3 p.Gln79Arg Uncertain significance Single submitter
- IGFBP3 p.Glu207Gln Uncertain significance Single submitter
- IGFBP3 p.Glu86Gln Uncertain significance Single submitter
- IGFBP3 p.Gly21Trp Uncertain significance Single submitter
- IGFBP3 p.Gly68Ser Uncertain significance Single submitter
- IGFBP3 p.His284Pro Uncertain significance Single submitter
- IGFBP3 p.Leu8Val Uncertain significance Single submitter
- IGFBP3 p.Pro134Ser Uncertain significance Single submitter
- IGFBP3 p.Pro65Ser Uncertain significance Single submitter
- IGFBP3 p.Ser204Ala Uncertain significance Single submitter
- IGFBP3 p.Thr157Ala Uncertain significance Single submitter
- IGFBP3 p.Thr72Arg Uncertain significance Single submitter
- IGFBP3 p.Tyr186Phe Uncertain significance Single submitter
- IGFBP3 p.Tyr210Phe Uncertain significance Single submitter
- IGFBP3 p.Val160Leu Uncertain significance Single submitter
- IGFBP3 p.Val283Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All IGFBP3 variants
Benign 3
- c.404-8G>A Single submitter
- p.Gly234Ser Single submitter ⚠
- p.Ser194= Single submitter
Uncertain significance 35
- c.403+13C>A Single submitter
- p.Ala10Gly Single submitter ⚠
- p.Ala10Ser Single submitter ⚠
- p.Ala117Thr Single submitter ⚠
- p.Ala130Val Single submitter ⚠
- p.Ala137Val Single submitter ⚠
- p.Ala47Pro Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala56Ser Single submitter ⚠
- p.Arg214Gly Single submitter ⚠
- p.Arg233Met Single submitter
- p.Arg259Gln Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg93Leu Single submitter ⚠
- p.Gln198Glu Single submitter ⚠
- p.Gln79Arg Single submitter ⚠
- p.Glu207Gln Single submitter ⚠
- p.Glu86Gln Single submitter ⚠
- p.Gly21Trp Single submitter ⚠
- p.Gly234Asp Single submitter
- p.Gly68Ser Single submitter ⚠
- p.His284Pro Single submitter ⚠
- p.Leu230Arg Single submitter ⚠
- p.Leu8Val Single submitter ⚠
- p.Pro134Ser Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Ser204Ala Single submitter ⚠
- p.Thr157Ala Single submitter ⚠
- p.Thr72Arg Single submitter ⚠
- p.Tyr186Phe Single submitter ⚠
- p.Tyr210Phe Single submitter ⚠
- p.Val160Leu Single submitter ⚠
- p.Val235Ala Single submitter ⚠
- p.Val283Met Single submitter ⚠