IGFBP5 — 43 ClinVar variants
All ClinVar germline IGFBP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
1 Likely benign · 42 Uncertain significance
Full IGFBP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IGFBP5 p.Ala180Val Uncertain significance Single submitter
- IGFBP5 p.Ala6Thr Uncertain significance Single submitter
- IGFBP5 p.Arg107Ser Uncertain significance Single submitter
- IGFBP5 p.Arg117His Uncertain significance Single submitter
- IGFBP5 p.Arg138Gln Uncertain significance Single submitter
- IGFBP5 p.Arg143His Uncertain significance Single submitter
- IGFBP5 p.Arg156His Uncertain significance Single submitter
- IGFBP5 p.Arg176Gln Uncertain significance Single submitter
- IGFBP5 p.Arg176Trp Uncertain significance Single submitter
- IGFBP5 p.Arg212Cys Uncertain significance Single submitter
- IGFBP5 p.Asp267Glu Uncertain significance Single submitter
- IGFBP5 p.Asp85Glu Uncertain significance Single submitter
- IGFBP5 p.Cys30Ser Uncertain significance Single submitter
- IGFBP5 p.Gln84Pro Uncertain significance Single submitter
- IGFBP5 p.Glu146Lys Uncertain significance Single submitter
- IGFBP5 p.Glu32Lys Uncertain significance Single submitter
- IGFBP5 p.Gly96Ser Uncertain significance Single submitter
- IGFBP5 p.Ile136Met Uncertain significance Single submitter
- IGFBP5 p.Leu81Phe Uncertain significance Single submitter
- IGFBP5 p.Lys135Gln Uncertain significance Single submitter
- IGFBP5 p.Met196Val Uncertain significance Single submitter
- IGFBP5 p.Met254Ile Uncertain significance Single submitter
- IGFBP5 p.Met37Val Uncertain significance Single submitter
- IGFBP5 p.Phe266Val Uncertain significance Single submitter
- IGFBP5 p.Pro17Arg Uncertain significance Single submitter
- IGFBP5 p.Pro181Leu Uncertain significance Single submitter
- IGFBP5 p.Pro39Ser Uncertain significance Single submitter
- IGFBP5 p.Pro40Ala Uncertain significance Single submitter
- IGFBP5 p.Ser105Asn Uncertain significance Single submitter
- IGFBP5 p.Ser206Asn Uncertain significance Single submitter
- IGFBP5 p.Ser269Gly Uncertain significance Single submitter
- IGFBP5 p.Val214Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- IGFBP5 p.Arg221His Uncertain significance Single submitter
- IGFBP5 p.Asp267Asn Uncertain significance Single submitter
- IGFBP5 p.Cys263Arg Uncertain significance Single submitter
- IGFBP5 p.Glu170Lys Uncertain significance Single submitter
- IGFBP5 p.Gly253Ser Uncertain significance Single submitter
- IGFBP5 p.Phe137Leu Uncertain significance Single submitter
- IGFBP5 p.Phe24Leu Uncertain significance Single submitter
- IGFBP5 p.Pro232Ser Uncertain significance Single submitter
- IGFBP5 p.Ser269Arg Uncertain significance Single submitter
All IGFBP5 variants
Likely benign 1
- p.Asn270= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 42
- p.Ala180Val Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg107Ser Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg143His Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Arg176Trp Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Asp267Asn Single submitter ⚠
- p.Asp267Glu Single submitter ⚠
- p.Asp85Glu Single submitter ⚠
- p.Cys263Arg Single submitter ⚠
- p.Cys30Ser Single submitter ⚠
- p.Gln84Pro Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu32Lys Single submitter ⚠
- p.Gly253Ser Single submitter ⚠
- p.Gly96Ser Single submitter ⚠
- p.Ile136Met Single submitter ⚠
- p.Leu81Phe Single submitter ⚠
- p.Lys135Gln Single submitter ⚠
- p.Met196Val Single submitter ⚠
- p.Met254Ile Single submitter ⚠
- p.Met37Val Single submitter ⚠
- p.Phe137Leu Single submitter ⚠
- p.Phe24Leu Single submitter ⚠
- p.Phe266Val Single submitter ⚠
- p.Pro17Arg Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Pro232Ser Single submitter ⚠
- p.Pro39Leu Single submitter
- p.Pro39Ser Single submitter ⚠
- p.Pro40Ala Single submitter ⚠
- p.Ser105Asn Single submitter ⚠
- p.Ser206Asn Single submitter ⚠
- p.Ser269Arg Single submitter ⚠
- p.Ser269Gly Single submitter ⚠
- p.Val214Met Single submitter ⚠