IGFBP6 — 40 ClinVar variants
All ClinVar germline IGFBP6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
3 Benign · 1 Benign/Likely benign · 4 Likely benign · 32 Uncertain significance
Full IGFBP6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IGFBP6 p.Ala107Asp Uncertain significance Single submitter
- IGFBP6 p.Ala111Thr Uncertain significance Single submitter
- IGFBP6 p.Arg128His Uncertain significance Single submitter
- IGFBP6 p.Arg134Cys Uncertain significance Single submitter
- IGFBP6 p.Arg134His Uncertain significance Single submitter
- IGFBP6 p.Arg164Cys Uncertain significance Single submitter
- IGFBP6 p.Arg180Gln Uncertain significance Single submitter
- IGFBP6 p.Arg193Gln Uncertain significance Single submitter
- IGFBP6 p.Arg208Cys Uncertain significance Single submitter
- IGFBP6 p.Asn133Ser Uncertain significance Single submitter
- IGFBP6 p.Asp227Gly Uncertain significance Single submitter
- IGFBP6 p.Gln137His Uncertain significance Single submitter
- IGFBP6 p.Glu55Gly Uncertain significance Single submitter
- IGFBP6 p.Glu61Asp Uncertain significance Single submitter
- IGFBP6 p.Glu91Gln Uncertain significance Single submitter
- IGFBP6 p.Gly161Asp Uncertain significance Single submitter
- IGFBP6 p.Gly23Arg Uncertain significance Single submitter
- IGFBP6 p.Gly72Glu Uncertain significance Single submitter
- IGFBP6 p.Leu64His Uncertain significance Single submitter
- IGFBP6 p.Lys220Glu Uncertain significance Single submitter
- IGFBP6 p.Pro106Gln Uncertain significance Single submitter
- IGFBP6 p.Pro147Arg Uncertain significance Single submitter
- IGFBP6 p.Pro147His Uncertain significance Single submitter
- IGFBP6 p.Pro30Ser Uncertain significance Single submitter
- IGFBP6 p.Pro87Ala Uncertain significance Single submitter
- IGFBP6 p.Pro87Thr Uncertain significance Single submitter
- IGFBP6 p.Ser148Phe Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All IGFBP6 variants
Benign 3
- p.Ala153= Multiple submitters
- p.Asn151= Single submitter
- p.Gln205His Single submitter
Benign/Likely benign 1
- p.Arg217Gln Multiple submitters
Likely benign 4
- c.480+4C>T Single submitter
- p.His4Tyr Single submitter
- p.Lys88Glu Single submitter
- p.Arg199Gln No assertion criteria
Uncertain significance 32
- p.Ala107Asp Single submitter ⚠
- p.Ala111Thr Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg164Cys Single submitter ⚠
- p.Arg164His Single submitter
- p.Arg180Gln Single submitter ⚠
- p.Arg193Gln Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg208Cys Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asp227Gly Single submitter ⚠
- p.Gln137His Single submitter ⚠
- p.Glu55Gly Single submitter ⚠
- p.Glu61Asp Single submitter ⚠
- p.Glu91Gln Single submitter ⚠
- p.Gly161Asp Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.Gly72Glu Single submitter ⚠
- p.Leu10Pro Single submitter ⚠
- p.Leu64His Single submitter ⚠
- p.Lys220Glu Single submitter ⚠
- p.Pro106Gln Single submitter ⚠
- p.Pro147Arg Single submitter ⚠
- p.Pro147His Single submitter ⚠
- p.Pro30Ser Single submitter ⚠
- p.Pro87Ala Single submitter ⚠
- p.Pro87Thr Single submitter ⚠
- p.Ser148Phe Single submitter ⚠
- p.Val187Met Single submitter