IGSF10 — 697 ClinVar variants
All ClinVar germline IGSF10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 466 flagged for review →
21 Conflicting · 57 Benign · 9 Benign/Likely benign · 120 Likely benign · 490 Uncertain significance
Full IGSF10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 466
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 20
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
- IGSF10 p.Ala16Val Conflicting Single submitter
- IGSF10 p.Arg1937Gln Conflicting Single submitter
- IGSF10 p.Arg2144Lys Conflicting Single submitter
- IGSF10 p.Arg2216Gln Conflicting Single submitter
- IGSF10 p.Asn1705Ser Conflicting Single submitter
- IGSF10 p.Asn1891Ser Conflicting Single submitter
- IGSF10 p.Gly26Ser Conflicting Single submitter
- IGSF10 p.Gly369Ser Conflicting Single submitter
- IGSF10 p.Ile1192Val Conflicting Single submitter
- IGSF10 p.Lys1049Glu Conflicting Single submitter
- IGSF10 p.Lys1286Glu Conflicting Single submitter
- IGSF10 p.Pro342Ser Conflicting Single submitter
-
IGSF10 p.Pro746Arg
Conflicting
Single submitter
primary ovarian failure
- IGSF10 p.Pro787Leu Conflicting Single submitter
- IGSF10 p.Ser1179Leu Conflicting Single submitter
- IGSF10 p.Thr2572Met Conflicting Single submitter
- IGSF10 p.Val1490Met Conflicting Single submitter
- IGSF10 p.Val2006Ile Conflicting Single submitter
- IGSF10 p.Val2323Met Conflicting Single submitter
- IGSF10 p.Val493Ile Conflicting Single submitter
Predictors lean, ClinVar uncertain 397
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 397
- IGSF10 p.Ala275Thr Uncertain significance Multiple submitters
- IGSF10 p.Arg1484Thr Uncertain significance Multiple submitters
- IGSF10 p.Arg1684Thr Uncertain significance Multiple submitters
- IGSF10 p.Arg2403Gln Uncertain significance Multiple submitters
- IGSF10 p.Arg2529Gln Uncertain significance Multiple submitters
- IGSF10 p.Arg32Cys Uncertain significance Multiple submitters
- IGSF10 p.Arg699Cys Uncertain significance Multiple submitters
- IGSF10 p.Asn1954Tyr Uncertain significance Multiple submitters
- IGSF10 p.Asn219Ser Uncertain significance Multiple submitters
- IGSF10 p.Asp1488Asn Uncertain significance Multiple submitters
- IGSF10 p.Gln2384Arg Uncertain significance Multiple submitters
- IGSF10 p.Glu1383Lys Uncertain significance Multiple submitters
- IGSF10 p.Glu683Lys Uncertain significance Multiple submitters
-
IGSF10 p.Gly1826Asp
Uncertain significance
Multiple submitters
primary ovarian failure
- IGSF10 p.Gly588Ser Uncertain significance Multiple submitters
- IGSF10 p.His135Pro Uncertain significance Multiple submitters
- IGSF10 p.Ile1583Thr Uncertain significance Multiple submitters
- IGSF10 p.Ile2370Thr Uncertain significance Multiple submitters
- IGSF10 p.Ile2425Leu Uncertain significance Multiple submitters
- IGSF10 p.Ile2484Val Uncertain significance Multiple submitters
- IGSF10 p.Lys1633Arg Uncertain significance Multiple submitters
- IGSF10 p.Met1473Val Uncertain significance Multiple submitters
- IGSF10 p.Met1974Thr Uncertain significance Multiple submitters
- IGSF10 p.Met870Ile Uncertain significance Multiple submitters
- IGSF10 p.Phe737Ser Uncertain significance Multiple submitters
- IGSF10 p.Pro1358Arg Uncertain significance Multiple submitters
- IGSF10 p.Pro2337Leu Uncertain significance Multiple submitters
- IGSF10 p.Ser1226Asn Uncertain significance Multiple submitters
- IGSF10 p.Ser1544Phe Uncertain significance Multiple submitters
- IGSF10 p.Ser1879Ala Uncertain significance Multiple submitters
- IGSF10 p.Ser453Ala Uncertain significance Multiple submitters
- IGSF10 p.Ser962Asn Uncertain significance Multiple submitters
- IGSF10 p.Thr1123Pro Uncertain significance Multiple submitters
- IGSF10 p.Thr1178Ile Uncertain significance Multiple submitters
- IGSF10 p.Thr1196Ala Uncertain significance Multiple submitters
- IGSF10 p.Thr2572Arg Uncertain significance Multiple submitters
- IGSF10 p.Thr784Ile Uncertain significance Multiple submitters
- IGSF10 p.Tyr207Cys Uncertain significance Multiple submitters
- IGSF10 p.Tyr556Asp Uncertain significance Multiple submitters
- IGSF10 p.Tyr616Cys Uncertain significance Multiple submitters
- IGSF10 p.Ala1056Val Uncertain significance Single submitter
- IGSF10 p.Ala1232Thr Uncertain significance Single submitter
- IGSF10 p.Ala1232Val Uncertain significance Single submitter
- IGSF10 p.Ala1327Val Uncertain significance Single submitter
- IGSF10 p.Ala1382Val Uncertain significance Single submitter
- IGSF10 p.Ala1392Val Uncertain significance Single submitter
- IGSF10 p.Ala1666Thr Uncertain significance Single submitter
- IGSF10 p.Ala1725Pro Uncertain significance Single submitter
- IGSF10 p.Ala1908Val Uncertain significance Single submitter
- IGSF10 p.Ala1946Val Uncertain significance Single submitter
- IGSF10 p.Ala1965Asp Uncertain significance Single submitter
- IGSF10 p.Ala2112Val Uncertain significance Single submitter
- IGSF10 p.Ala2194Val Uncertain significance Single submitter
- IGSF10 p.Ala2249Asp Uncertain significance Single submitter
- IGSF10 p.Ala2263Thr Uncertain significance Single submitter
- IGSF10 p.Ala2438Val Uncertain significance Single submitter
- IGSF10 p.Ala2498Thr Uncertain significance Single submitter
- IGSF10 p.Ala252Val Uncertain significance Single submitter
- IGSF10 p.Ala2616Gly Uncertain significance Single submitter
- IGSF10 p.Ala274Val Uncertain significance Single submitter
- IGSF10 p.Ala344Val Uncertain significance Single submitter
- IGSF10 p.Ala408Ser Uncertain significance Single submitter
- IGSF10 p.Ala408Thr Uncertain significance Single submitter
- IGSF10 p.Ala463Thr Uncertain significance Single submitter
- IGSF10 p.Ala757Val Uncertain significance Single submitter
- IGSF10 p.Ala801Val Uncertain significance Single submitter
- IGSF10 p.Ala818Ser Uncertain significance Single submitter
- IGSF10 p.Ala900Glu Uncertain significance Single submitter
- IGSF10 p.Arg1021Gln Uncertain significance Single submitter
- IGSF10 p.Arg1033Trp Uncertain significance Single submitter
- IGSF10 p.Arg1164Cys Uncertain significance Single submitter
- IGSF10 p.Arg1164His Uncertain significance Single submitter
- IGSF10 p.Arg1197Lys Uncertain significance Single submitter
- IGSF10 p.Arg1197Ser Uncertain significance Single submitter
- IGSF10 p.Arg1355Thr Uncertain significance Single submitter
- IGSF10 p.Arg156Leu Uncertain significance Single submitter
- IGSF10 p.Arg1649Lys Uncertain significance Single submitter
- IGSF10 p.Arg1649Thr Uncertain significance Single submitter
- IGSF10 p.Arg1699Lys Uncertain significance Single submitter
- IGSF10 p.Arg1750Thr Uncertain significance Single submitter
- IGSF10 p.Arg1751Ser Uncertain significance Single submitter
- IGSF10 p.Arg1772Gly Uncertain significance Single submitter
- IGSF10 p.Arg2092Gly Uncertain significance Single submitter
- IGSF10 p.Arg2189Gly Uncertain significance Single submitter
- IGSF10 p.Arg2189Lys Uncertain significance Single submitter
- IGSF10 p.Arg2244Thr Uncertain significance Single submitter
- IGSF10 p.Arg2403Trp Uncertain significance Single submitter
- IGSF10 p.Arg2536Lys Uncertain significance Single submitter
- IGSF10 p.Arg2577Thr Uncertain significance Single submitter
- IGSF10 p.Arg31Cys Uncertain significance Single submitter
- IGSF10 p.Arg31His Uncertain significance Single submitter
- IGSF10 p.Arg32His Uncertain significance Single submitter
- IGSF10 p.Arg423Ile Uncertain significance Single submitter
- IGSF10 p.Arg462Lys Uncertain significance Single submitter
- IGSF10 p.Arg46Gln Uncertain significance Single submitter
- IGSF10 p.Arg527Trp Uncertain significance Single submitter
- IGSF10 p.Arg61Cys Uncertain significance Single submitter
- IGSF10 p.Arg644His Uncertain significance Single submitter
- IGSF10 p.Arg668Lys Uncertain significance Single submitter
- IGSF10 p.Arg722Trp Uncertain significance Single submitter
- IGSF10 p.Arg728Gln Uncertain significance Single submitter
- IGSF10 p.Arg735Gln Uncertain significance Single submitter
- IGSF10 p.Arg736His Uncertain significance Single submitter
- IGSF10 p.Arg826Ser Uncertain significance Single submitter
- IGSF10 p.Arg826Thr Uncertain significance Single submitter
- IGSF10 p.Asn1221Asp Uncertain significance Single submitter
- IGSF10 p.Asn1489Lys Uncertain significance Single submitter
- IGSF10 p.Asn1899Ser Uncertain significance Single submitter
- IGSF10 p.Asn1962Ser Uncertain significance Single submitter
- IGSF10 p.Asn2082Lys Uncertain significance Single submitter
- IGSF10 p.Asn2101Ile Uncertain significance Single submitter
- IGSF10 p.Asn2150Lys Uncertain significance Single submitter
- IGSF10 p.Asn2217Lys Uncertain significance Single submitter
- IGSF10 p.Asn2381Lys Uncertain significance Single submitter
- IGSF10 p.Asn2393Lys Uncertain significance Single submitter
- IGSF10 p.Asn329His Uncertain significance Single submitter
- IGSF10 p.Asn349Ser Uncertain significance Single submitter
- IGSF10 p.Asn365Asp Uncertain significance Single submitter
- IGSF10 p.Asn58Ser Uncertain significance Single submitter
- IGSF10 p.Asn720Ser Uncertain significance Single submitter
- IGSF10 p.Asn774Thr Uncertain significance Single submitter
- IGSF10 p.Asn788Asp Uncertain significance Single submitter
- IGSF10 p.Asn875Asp Uncertain significance Single submitter
- IGSF10 p.Asn967Ser Uncertain significance Single submitter
- IGSF10 p.Asp1957His Uncertain significance Single submitter
- IGSF10 p.Asp2059Asn Uncertain significance Single submitter
- IGSF10 p.Asp210Asn Uncertain significance Single submitter
- IGSF10 p.Asp212Gly Uncertain significance Single submitter
- IGSF10 p.Asp2157Ala Uncertain significance Single submitter
- IGSF10 p.Asp2168Ala Uncertain significance Single submitter
- IGSF10 p.Asp2221Glu Uncertain significance Single submitter
- IGSF10 p.Asp2221Val Uncertain significance Single submitter
- IGSF10 p.Asp2229Ala Uncertain significance Single submitter
- IGSF10 p.Asp2277Gly Uncertain significance Single submitter
- IGSF10 p.Asp2405Glu Uncertain significance Single submitter
- IGSF10 p.Asp350Gly Uncertain significance Single submitter
- IGSF10 p.Asp367Asn Uncertain significance Single submitter
- IGSF10 p.Asp432Ala Uncertain significance Single submitter
- IGSF10 p.Asp513Val Uncertain significance Single submitter
- IGSF10 p.Asp525His Uncertain significance Single submitter
- IGSF10 p.Asp602Glu Uncertain significance Single submitter
- IGSF10 p.Asp621Asn Uncertain significance Single submitter
- IGSF10 p.Asp76Gly Uncertain significance Single submitter
- IGSF10 p.Asp905Glu Uncertain significance Single submitter
- IGSF10 p.Asp930Glu Uncertain significance Single submitter
- IGSF10 p.Asp98Gly Uncertain significance Single submitter
- IGSF10 p.Cys1063Tyr Uncertain significance Single submitter
- IGSF10 p.Cys1723Arg Uncertain significance Single submitter
- IGSF10 p.Cys1864Gly Uncertain significance Single submitter
- IGSF10 p.Cys2060Ser Uncertain significance Single submitter
Predictors split 49
The independent predictors disagree with each other — read with care.
- IGSF10 p.Ala1666Gly Uncertain significance Multiple submitters
- IGSF10 p.Ala1725Thr Uncertain significance Multiple submitters
- IGSF10 p.Arg2410His Uncertain significance Multiple submitters
- IGSF10 p.Arg2533Cys Uncertain significance Multiple submitters
- IGSF10 p.Asn2375Ser Uncertain significance Multiple submitters
- IGSF10 p.Asp2614Asn Benign/Likely benign Multiple submitters
- IGSF10 p.Glu161Lys Benign/Likely benign Multiple submitters
- IGSF10 p.Ile2523Thr Benign/Likely benign Multiple submitters
- IGSF10 p.Pro385Leu Uncertain significance Multiple submitters
- IGSF10 p.Ser1879Cys Uncertain significance Multiple submitters
- IGSF10 p.Ser2613Gly Uncertain significance Multiple submitters
- IGSF10 p.Ser843Cys Likely benign Multiple submitters
- IGSF10 p.Thr443Ile Uncertain significance Multiple submitters
- IGSF10 p.Ala1769Gly Uncertain significance Single submitter
- IGSF10 p.Ala2038Asp Uncertain significance Single submitter
- IGSF10 p.Arg1009Cys Benign Single submitter
- IGSF10 p.Arg1751Cys Uncertain significance Single submitter
- IGSF10 p.Arg644Cys Uncertain significance Single submitter
- IGSF10 p.Arg729Cys Uncertain significance Single submitter
- IGSF10 p.Arg736Cys Uncertain significance Single submitter
- IGSF10 p.Asn2123Ser Uncertain significance Single submitter
- IGSF10 p.Asn2217Ser Uncertain significance Single submitter
-
IGSF10 p.Asp2025His
Uncertain significance
Single submitter
IGSF10-related disorder
- IGSF10 p.Asp76Tyr Uncertain significance Single submitter
- IGSF10 p.Cys33Tyr Uncertain significance Single submitter
- IGSF10 p.Gly1719Ala Uncertain significance Single submitter
- IGSF10 p.Gly1760Arg Uncertain significance Single submitter
- IGSF10 p.Gly2447Arg Uncertain significance Single submitter
- IGSF10 p.Gly65Arg Uncertain significance Single submitter
- IGSF10 p.His217Arg Uncertain significance Single submitter
- IGSF10 p.His42Arg Uncertain significance Single submitter
- IGSF10 p.Ile1710Met Uncertain significance Single submitter
- IGSF10 p.Ile1852Thr Uncertain significance Single submitter
- IGSF10 p.Ile2390Thr Uncertain significance Single submitter
- IGSF10 p.Ile2464Thr Uncertain significance Single submitter
- IGSF10 p.Ile2620Met Uncertain significance Single submitter
- IGSF10 p.Leu354Pro Uncertain significance Single submitter
- IGSF10 p.Lys228Thr Uncertain significance Single submitter
- IGSF10 p.Lys2604Glu Conflicting Single submitter
- IGSF10 p.Met208Ile Uncertain significance Single submitter
- IGSF10 p.Phe1393Leu Uncertain significance Single submitter
- IGSF10 p.Phe186Leu Uncertain significance Single submitter
- IGSF10 p.Pro1745Ser Uncertain significance Single submitter
- IGSF10 p.Pro30Leu Uncertain significance Single submitter
- IGSF10 p.Pro505Ser Uncertain significance Single submitter
- IGSF10 p.Ser1149Cys Uncertain significance Single submitter
- IGSF10 p.Ser1339Cys Uncertain significance Single submitter
- IGSF10 p.Thr2618Met Uncertain significance Single submitter
- IGSF10 p.Val174Phe Uncertain significance Single submitter
All IGSF10 variants
Conflicting classifications of pathogenicity 21
- p.Ala16Val Single submitter ⚠
- p.Arg1937Gln Single submitter ⚠
- p.Arg2144Lys Single submitter ⚠
- p.Arg2216Gln Single submitter ⚠
- p.Asn1705Ser Single submitter ⚠
- p.Asn1891Ser Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Gly369Ser Single submitter ⚠
- p.Ile1192Val Single submitter ⚠
- p.Lys1049Glu Single submitter ⚠
- p.Lys1286Glu Single submitter ⚠
- p.Lys2604Glu Single submitter ⚠
- p.Pro342Ser Single submitter ⚠
- p.Pro746Arg Single submitter primary ovarian failure ⚠
- p.Pro787Leu Single submitter ⚠
- p.Ser1179Leu Single submitter ⚠
- p.Thr2572Met Single submitter ⚠
- p.Val1490Met Single submitter ⚠
- p.Val2006Ile Single submitter ⚠
- p.Val2323Met Single submitter ⚠
- p.Val493Ile Single submitter ⚠
Benign 57
- p.Ala1382= Multiple submitters
- p.Ala1769= Multiple submitters
- p.Ala2406Val Multiple submitters
- p.Arg1032Gln Multiple submitters
- p.Arg2476Trp Multiple submitters
- p.Asn115= Multiple submitters
- p.Asn2243= Multiple submitters
- p.Gln2384= Multiple submitters
- p.Gln449= Multiple submitters
- p.Gln667Lys Multiple submitters
- p.Gln697= Multiple submitters
- p.Glu960Gln Multiple submitters
- p.Gly2418= Multiple submitters
- p.His2579Tyr Multiple submitters
- p.Ile1311Val Multiple submitters
- p.Leu176= Multiple submitters
- p.Leu2161= Multiple submitters
- p.Leu2435= Multiple submitters
- p.Leu2450= Multiple submitters
- p.Pro2367= Multiple submitters
- p.Pro571Ser Multiple submitters
- p.Ser1199Ala Multiple submitters
- p.Ser2197= Multiple submitters
- p.Ser2322= Multiple submitters
- p.Thr124Ile Multiple submitters
- p.Thr132= Multiple submitters
- p.Thr1370Ile Multiple submitters
- p.Thr2518fs Multiple submitters
- p.Thr2561= Multiple submitters
- p.Tyr150Asp Multiple submitters
- p.Tyr1875His Multiple submitters
- p.Tyr36= Multiple submitters
- p.Val1522Ile Multiple submitters
- c.324+19G>A Single submitter
- c.5062+5G>A Single submitter
- c.5964-17dup Single submitter
- p.Ala2112= Single submitter
- p.Arg1009Cys Single submitter ⚠
- p.Arg1355Ser Single submitter
- p.Arg722Gln Single submitter
- p.Asp557= Single submitter
- p.Asp795Asn Single submitter
- p.Gln785= Single submitter
- p.Gln888Pro Single submitter
- p.Glu574Lys Single submitter
- p.Gly2458= Single submitter
- p.Ile1536Thr Single submitter
- p.Ile458Val Single submitter
- p.Met664Thr Single submitter
- p.Phe1252= Single submitter
- p.Phe1368= Single submitter
- p.Pro461Leu Single submitter
- p.Thr1933= Single submitter
- p.Thr2149= Single submitter
- p.Tyr2211= Single submitter
- p.Tyr2437= Single submitter
- p.Val1874Ile Single submitter
Benign/Likely benign 9
- p.Ala1532= Multiple submitters
- p.Asn1906= Multiple submitters
- p.Asp2614Asn Multiple submitters ⚠
- p.Glu161Lys Multiple submitters ⚠
- p.Ile2523Thr Multiple submitters ⚠
- p.Leu1546= Multiple submitters
- p.Ser2063= Multiple submitters
- p.Thr1238Ala Multiple submitters
- p.Thr951Lys Multiple submitters
Likely benign 120
- p.Arg118Gln Multiple submitters
- p.Asp1802Val Multiple submitters
- p.Gln1348Lys Multiple submitters
- p.Leu2452fs Multiple submitters
- p.Leu759= Multiple submitters
- p.Lys623= Multiple submitters
- p.Pro809= Multiple submitters
- p.Ser292Asn Multiple submitters
- p.Ser843Cys Multiple submitters ⚠
- p.Thr1266Ser Multiple submitters
- p.Tyr2504Cys Multiple submitters
- c.194+19T>C Single submitter
- c.324+18A>G Single submitter
- c.325-17T>C Single submitter
- c.325-3T>C Single submitter
- c.5062+20T>A Single submitter
- c.5063-8C>A Single submitter
- p.Ala1095Pro Single submitter
- p.Ala1491= Single submitter
- p.Ala2309= Single submitter
- p.Ala2438= Single submitter
- p.Ala463= Single submitter
- p.Ala512Gly Single submitter
- p.Ala696Val Single submitter
- p.Arg1035Thr Single submitter
- p.Arg156His Single submitter
- p.Arg1750= Single submitter
- p.Arg1848Lys Single submitter
- p.Arg2216Ter Single submitter
- p.Arg729His Single submitter
- p.Arg736_Phe737insTer Single submitter
- p.Arg750= Single submitter
- p.Arg772Gln Single submitter
- p.Asn1159= Single submitter
- p.Asn1489= Single submitter
- p.Asn2082Ser Single submitter
- p.Asn2393= Single submitter
- p.Asn417= Single submitter
- p.Asp123= Single submitter
- p.Asp1802= Single submitter
- p.Asp2487Glu Single submitter
- p.Asp682Gly Single submitter
- p.Asp794= Single submitter
- p.Asp930= Single submitter
- p.Cys255= Single submitter
- p.Cys595fs Single submitter
- p.Gln1107= Single submitter
- p.Gln2327= Single submitter
- p.Gln2583His Single submitter
- p.Gln727Arg Single submitter
- p.Gln881Lys Single submitter
- p.Glu1602Ter Single submitter
- p.Glu855= Single submitter
- p.Gly1496Arg Single submitter
- p.Gly2077= Single submitter
- p.Gly2513= Single submitter
- p.Gly547= Single submitter
- p.Gly709Val Single submitter
- p.His506= Single submitter
- p.His734Asn Single submitter
- p.His94Tyr Single submitter
- p.Ile1436Thr Single submitter
- p.Ile2153Val Single submitter
- p.Ile2187Thr Single submitter
- p.Ile62= Single submitter
- p.Ile882Met Single submitter
- p.Leu152= Single submitter
- p.Leu562= Single submitter
- p.Leu800= Single submitter
- p.Lys167= Single submitter
- p.Met2468Val Single submitter
- p.Pro1323del Single submitter
- p.Pro1362= Single submitter
- p.Pro1579= Single submitter
- p.Pro268= Single submitter
- p.Pro505= Single submitter
- p.Pro56= Single submitter
- p.Ser1099Thr Single submitter
- p.Ser1525= Single submitter
- p.Ser1759= Single submitter
- p.Ser1788Ter Single submitter
- p.Ser1794Asn Single submitter
- p.Ser1925= Single submitter
- p.Ser1991= Single submitter
- p.Ser2000fs Single submitter
- p.Ser2306= Single submitter
- p.Ser2360= Single submitter
- p.Ser2598= Single submitter
- p.Ser333= Single submitter
- p.Ser427Pro Single submitter
- p.Ser716fs Single submitter
- p.Ser891= Single submitter
- p.Thr1274Met Single submitter
- p.Thr1308= Single submitter
- p.Thr1324= Single submitter
- p.Thr1538Ile Single submitter
- p.Thr172= Single submitter
- p.Thr2191= Single submitter
- p.Thr2618= Single submitter
- p.Thr584fs Single submitter
- p.Thr868= Single submitter
- p.Thr886= Single submitter
- p.Thr981= Single submitter
- p.Thr981Met Single submitter
- p.Tyr2045His Single submitter
- p.Tyr368= Single submitter
- p.Tyr404= Single submitter
- p.Tyr549His Single submitter
- p.Val1119= Single submitter
- p.Val1713= Single submitter
- p.Val1837= Single submitter
- p.Val1995Ile Single submitter
- p.Val548Ile Single submitter
- p.Val782Met Single submitter
- p.Ala869= No assertion criteria IGSF10-related disorder
- p.Arg1009His No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Gly1017= No assertion criteria IGSF10-related disorder
- p.Ser1179= No assertion criteria IGSF10-related disorder
- p.Ser1385Ter No assertion criteria IGSF10-related disorder
- p.Thr2135= No assertion criteria IGSF10-related disorder
Uncertain significance 490
Showing the top 300 by review status; the full set is in the sitemap.
- p.Ala1666Gly Multiple submitters ⚠
- p.Ala1725Thr Multiple submitters ⚠
- p.Ala275Thr Multiple submitters ⚠
- p.Arg1484Thr Multiple submitters ⚠
- p.Arg1684Thr Multiple submitters ⚠
- p.Arg2403Gln Multiple submitters ⚠
- p.Arg2410His Multiple submitters ⚠
- p.Arg2529Gln Multiple submitters ⚠
- p.Arg2533Cys Multiple submitters ⚠
- p.Arg32Cys Multiple submitters ⚠
- p.Arg61His Multiple submitters Martsolf syndrome 1
- p.Arg699Cys Multiple submitters ⚠
- p.Asn1954Tyr Multiple submitters ⚠
- p.Asn219Ser Multiple submitters ⚠
- p.Asn2375Ser Multiple submitters ⚠
- p.Asp1488Asn Multiple submitters ⚠
- p.Gln2384Arg Multiple submitters ⚠
- p.Glu1383Lys Multiple submitters ⚠
- p.Glu683Lys Multiple submitters ⚠
- p.Gly1826Asp Multiple submitters primary ovarian failure ⚠
- p.Gly588Ser Multiple submitters ⚠
- p.His135Pro Multiple submitters ⚠
- p.His2133Pro Multiple submitters
- p.Ile1583Thr Multiple submitters ⚠
- p.Ile2370Thr Multiple submitters ⚠
- p.Ile2420Thr Multiple submitters
- p.Ile2425Leu Multiple submitters ⚠
- p.Ile2425Lys Multiple submitters
- p.Ile2484Val Multiple submitters ⚠
- p.Lys1633Arg Multiple submitters ⚠
- p.Met1473Val Multiple submitters ⚠
- p.Met1974Thr Multiple submitters ⚠
- p.Met870Ile Multiple submitters ⚠
- p.Phe737Ser Multiple submitters ⚠
- p.Pro1358Arg Multiple submitters ⚠
- p.Pro2337Leu Multiple submitters ⚠
- p.Pro385Leu Multiple submitters ⚠
- p.Ser1226Asn Multiple submitters ⚠
- p.Ser1544Phe Multiple submitters ⚠
- p.Ser1879Ala Multiple submitters ⚠
- p.Ser1879Cys Multiple submitters ⚠
- p.Ser1925Leu Multiple submitters
- p.Ser2613Gly Multiple submitters ⚠
- p.Ser453Ala Multiple submitters ⚠
- p.Ser962Asn Multiple submitters ⚠
- p.Thr1123Pro Multiple submitters ⚠
- p.Thr1178Ile Multiple submitters ⚠
- p.Thr1196Ala Multiple submitters ⚠
- p.Thr2572Arg Multiple submitters ⚠
- p.Thr443Ile Multiple submitters ⚠
- p.Thr784Ile Multiple submitters ⚠
- p.Tyr207Cys Multiple submitters ⚠
- p.Tyr556Asp Multiple submitters ⚠
- p.Tyr616Cys Multiple submitters ⚠
- c.715+1G>C Single submitter
- p.Ala1056Val Single submitter ⚠
- p.Ala1160fs Single submitter
- p.Ala1232Thr Single submitter ⚠
- p.Ala1232Val Single submitter ⚠
- p.Ala1327Val Single submitter ⚠
- p.Ala1382Val Single submitter ⚠
- p.Ala1392Val Single submitter ⚠
- p.Ala1666Thr Single submitter ⚠
- p.Ala1725Pro Single submitter ⚠
- p.Ala1769Gly Single submitter ⚠
- p.Ala1908Val Single submitter ⚠
- p.Ala1946Val Single submitter ⚠
- p.Ala1965Asp Single submitter ⚠
- p.Ala2038Asp Single submitter ⚠
- p.Ala2112Val Single submitter ⚠
- p.Ala2194Val Single submitter ⚠
- p.Ala2249Asp Single submitter ⚠
- p.Ala2263Thr Single submitter ⚠
- p.Ala2438Val Single submitter ⚠
- p.Ala2498Thr Single submitter ⚠
- p.Ala252Val Single submitter ⚠
- p.Ala2616Gly Single submitter ⚠
- p.Ala2617fs Single submitter primary ovarian failure
- p.Ala274Val Single submitter ⚠
- p.Ala344Val Single submitter ⚠
- p.Ala408Ser Single submitter ⚠
- p.Ala408Thr Single submitter ⚠
- p.Ala463Thr Single submitter ⚠
- p.Ala757Val Single submitter ⚠
- p.Ala801Val Single submitter ⚠
- p.Ala818Ser Single submitter ⚠
- p.Ala900Glu Single submitter ⚠
- p.Arg1021Gln Single submitter ⚠
- p.Arg1033Trp Single submitter ⚠
- p.Arg1164Cys Single submitter ⚠
- p.Arg1164His Single submitter ⚠
- p.Arg118Ter Single submitter
- p.Arg1197Lys Single submitter ⚠
- p.Arg1197Ser Single submitter ⚠
- p.Arg1338fs Single submitter
- p.Arg133Gln Single submitter
- p.Arg1355Thr Single submitter ⚠
- p.Arg156Leu Single submitter ⚠
- p.Arg1649Lys Single submitter ⚠
- p.Arg1649Thr Single submitter ⚠
- p.Arg1699Lys Single submitter ⚠
- p.Arg1750Thr Single submitter ⚠
- p.Arg1751Cys Single submitter ⚠
- p.Arg1751Ser Single submitter ⚠
- p.Arg1772Gly Single submitter ⚠
- p.Arg1815Gly Single submitter
- p.Arg2092Gly Single submitter ⚠
- p.Arg2189Gly Single submitter ⚠
- p.Arg2189Lys Single submitter ⚠
- p.Arg2244Thr Single submitter ⚠
- p.Arg2403Trp Single submitter ⚠
- p.Arg2536Lys Single submitter ⚠
- p.Arg2577Thr Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Arg32His Single submitter ⚠
- p.Arg423Ile Single submitter ⚠
- p.Arg440Ter Single submitter
- p.Arg462Lys Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg527Trp Single submitter ⚠
- p.Arg61Cys Single submitter ⚠
- p.Arg644Cys Single submitter ⚠
- p.Arg644His Single submitter ⚠
- p.Arg668Lys Single submitter ⚠
- p.Arg722Trp Single submitter ⚠
- p.Arg728Gln Single submitter ⚠
- p.Arg728Ter Single submitter
- p.Arg729Cys Single submitter ⚠
- p.Arg735Gln Single submitter ⚠
- p.Arg736Cys Single submitter ⚠
- p.Arg736His Single submitter ⚠
- p.Arg826Ser Single submitter ⚠
- p.Arg826Thr Single submitter ⚠
- p.Asn1221Asp Single submitter ⚠
- p.Asn1489Lys Single submitter ⚠
- p.Asn1899Ser Single submitter ⚠
- p.Asn1962Ser Single submitter ⚠
- p.Asn2082Lys Single submitter ⚠
- p.Asn2101Ile Single submitter ⚠
- p.Asn2123Ser Single submitter ⚠
- p.Asn2150Lys Single submitter ⚠
- p.Asn2217Lys Single submitter ⚠
- p.Asn2217Ser Single submitter ⚠
- p.Asn2381Lys Single submitter ⚠
- p.Asn2393Lys Single submitter ⚠
- p.Asn329His Single submitter ⚠
- p.Asn349Ser Single submitter ⚠
- p.Asn365Asp Single submitter ⚠
- p.Asn58Ser Single submitter ⚠
- p.Asn720Ser Single submitter ⚠
- p.Asn774Thr Single submitter ⚠
- p.Asn788Asp Single submitter ⚠
- p.Asn875Asp Single submitter ⚠
- p.Asn967Ser Single submitter ⚠
- p.Asp1245fs Single submitter
- p.Asp1957His Single submitter ⚠
- p.Asp2025His Single submitter IGSF10-related disorder ⚠
- p.Asp2059Asn Single submitter ⚠
- p.Asp210Asn Single submitter ⚠
- p.Asp212Gly Single submitter ⚠
- p.Asp2157Ala Single submitter ⚠
- p.Asp2168Ala Single submitter ⚠
- p.Asp2221Glu Single submitter ⚠
- p.Asp2221Val Single submitter ⚠
- p.Asp2229Ala Single submitter ⚠
- p.Asp2277Gly Single submitter ⚠
- p.Asp2405Glu Single submitter ⚠
- p.Asp350Gly Single submitter ⚠
- p.Asp367Asn Single submitter ⚠
- p.Asp432Ala Single submitter ⚠
- p.Asp513Val Single submitter ⚠
- p.Asp525His Single submitter ⚠
- p.Asp602Glu Single submitter ⚠
- p.Asp621Asn Single submitter ⚠
- p.Asp76Gly Single submitter ⚠
- p.Asp76Tyr Single submitter ⚠
- p.Asp905Glu Single submitter ⚠
- p.Asp930Glu Single submitter ⚠
- p.Asp98Gly Single submitter ⚠
- p.Cys1063Tyr Single submitter ⚠
- p.Cys1723Arg Single submitter ⚠
- p.Cys1864Gly Single submitter ⚠
- p.Cys2060Ser Single submitter ⚠
- p.Cys2313Ser Single submitter ⚠
- p.Cys2313Trp Single submitter ⚠
- p.Cys2605Gly Single submitter ⚠
- p.Cys33Tyr Single submitter ⚠
- p.Gln1261Arg Single submitter ⚠
- p.Gln1315Lys Single submitter ⚠
- p.Gln1574Lys Single submitter ⚠
- p.Gln1716Glu Single submitter ⚠
- p.Gln1792Ter Single submitter
- p.Gln2478His Single submitter ⚠
- p.Gln2587Ter Single submitter
- p.Gln2621Lys Single submitter ⚠
- p.Gln323His Single submitter ⚠
- p.Gln433fs Single submitter
- p.Gln433Lys Single submitter ⚠
- p.Gln449Pro Single submitter
- p.Gln883Lys Single submitter ⚠
- p.Gln955Glu Single submitter ⚠
- p.Gln993Glu Single submitter ⚠
- p.Glu1101Lys Single submitter ⚠
- p.Glu1114Gln Single submitter ⚠
- p.Glu142Asp Single submitter ⚠
- p.Glu1507Lys Single submitter ⚠
- p.Glu1671Ala Single submitter ⚠
- p.Glu1858Gly Single submitter ⚠
- p.Glu1968Lys Single submitter ⚠
- p.Glu2008Gly Single submitter ⚠
- p.Glu2129Asp Single submitter
- p.Glu2427Lys Single submitter ⚠
- p.Glu2448Ter Single submitter
- p.Glu2576Gln Single submitter ⚠
- p.Glu396Asp Single submitter ⚠
- p.Glu537Gln Single submitter ⚠
- p.Glu773Gly Single submitter ⚠
- p.Glu84Lys Single submitter
- p.Gly1140Ser Single submitter ⚠
- p.Gly1599Val Single submitter ⚠
- p.Gly1706Ala Single submitter ⚠
- p.Gly1706Arg Single submitter ⚠
- p.Gly1719Ala Single submitter ⚠
- p.Gly1760Arg Single submitter ⚠
- p.Gly1760Ter Single submitter
- p.Gly1803Arg Single submitter
- p.Gly1868Arg Single submitter ⚠
- p.Gly2239Asp Single submitter ⚠
- p.Gly2447Arg Single submitter ⚠
- p.Gly2471Ala Single submitter ⚠
- p.Gly5Ser Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.Gly674Glu Single submitter ⚠
- p.Gly678Arg Single submitter
- p.Gly798Asp Single submitter ⚠
- p.Gly884Ser Single submitter ⚠
- p.His1034Gln Single submitter ⚠
- p.His1156Tyr Single submitter ⚠
- p.His1251Pro Single submitter ⚠
- p.His1278fs Single submitter IGSF10-related disorder
- p.His1459Tyr Single submitter ⚠
- p.His1548Pro Single submitter ⚠
- p.His1577Gln Single submitter ⚠
- p.His1987Gln Single submitter ⚠
- p.His1994Asp Single submitter ⚠
- p.His217Arg Single submitter ⚠
- p.His2258Tyr Single submitter ⚠
- p.His2293Gln Single submitter ⚠
- p.His2567Arg Single submitter ⚠
- p.His2585Arg Single submitter ⚠
- p.His370Tyr Single submitter ⚠
- p.His42Arg Single submitter ⚠
- p.His42Pro Single submitter ⚠
- p.His470Tyr Single submitter ⚠
- p.His711Asn Single submitter ⚠
- p.His915Arg Single submitter ⚠
- p.His954Tyr Single submitter ⚠
- p.Ile1023Thr Single submitter ⚠
- p.Ile1150Thr Single submitter ⚠
- p.Ile1311Ser Single submitter ⚠
- p.Ile1330Val Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Ile1650Thr Single submitter ⚠
- p.Ile1710Met Single submitter ⚠
- p.Ile1835Met Single submitter ⚠
- p.Ile1838Thr Single submitter ⚠
- p.Ile1852Thr Single submitter ⚠
- p.Ile18Met Single submitter ⚠
- p.Ile2237Ser Single submitter ⚠
- p.Ile2390Thr Single submitter ⚠
- p.Ile241Met Single submitter ⚠
- p.Ile2434Val Single submitter ⚠
- p.Ile2445_Ser2446insIle Single submitter
- p.Ile2464Thr Single submitter ⚠
- p.Ile2493Val Single submitter ⚠
- p.Ile2620Met Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Ile55Met Single submitter ⚠
- p.Ile566Val Single submitter ⚠
- p.Leu1031Gln Single submitter ⚠
- p.Leu1067Val Single submitter ⚠
- p.Leu1079Ser Single submitter ⚠
- p.Leu1181Phe Single submitter ⚠
- p.Leu1289Phe Single submitter ⚠
- p.Leu1415Pro Single submitter ⚠
- p.Leu1547Ser Single submitter ⚠
- p.Leu1635Val Single submitter ⚠
- p.Leu1640fs Single submitter
- p.Leu168Val Single submitter ⚠
- p.Leu2435Ile Single submitter ⚠
- p.Leu2569Phe Single submitter ⚠
- p.Leu354Pro Single submitter ⚠
- p.Leu378Ser Single submitter ⚠
- p.Leu400Phe Single submitter ⚠
- p.Leu429fs Single submitter
- p.Leu690Ile Single submitter ⚠
- p.Leu802Val Single submitter ⚠
- p.Lys116Glu Single submitter primary ovarian failure ⚠
- p.Lys1202Arg Single submitter ⚠