IGSF11 — 53 ClinVar variants
All ClinVar germline IGSF11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
53 Uncertain significance
Full IGSF11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IGSF11 p.Ala352Val Uncertain significance Single submitter
- IGSF11 p.Ala409Thr Uncertain significance Single submitter
- IGSF11 p.Arg320Gln Uncertain significance Single submitter
- IGSF11 p.Arg387Gly Uncertain significance Single submitter
- IGSF11 p.Arg5Cys Uncertain significance Single submitter
- IGSF11 p.Arg5Ser Uncertain significance Single submitter
- IGSF11 p.Asn315Ser Uncertain significance Single submitter
- IGSF11 p.Asn325Ser Uncertain significance Single submitter
- IGSF11 p.Asn353Ile Uncertain significance Single submitter
- IGSF11 p.Asn56Ser Uncertain significance Single submitter
- IGSF11 p.Asp114Ala Uncertain significance Single submitter
- IGSF11 p.Cys293Gly Uncertain significance Single submitter
- IGSF11 p.Gln343Pro Uncertain significance Single submitter
- IGSF11 p.Gly129Ala Uncertain significance Single submitter
- IGSF11 p.Gly250Asp Uncertain significance Single submitter
- IGSF11 p.Gly379Arg Uncertain significance Single submitter
- IGSF11 p.Gly390Ala Uncertain significance Single submitter
- IGSF11 p.Gly90Ser Uncertain significance Single submitter
- IGSF11 p.His369Arg Uncertain significance Single submitter
- IGSF11 p.Ile261Leu Uncertain significance Single submitter
- IGSF11 p.Ile414Phe Uncertain significance Single submitter
- IGSF11 p.Ile53Val Uncertain significance Single submitter
- IGSF11 p.Leu164Phe Uncertain significance Single submitter
- IGSF11 p.Lys297Arg Uncertain significance Single submitter
- IGSF11 p.Met81Val Uncertain significance Single submitter
- IGSF11 p.Phe347Ile Uncertain significance Single submitter
- IGSF11 p.Phe347Tyr Uncertain significance Single submitter
- IGSF11 p.Pro396Leu Uncertain significance Single submitter
- IGSF11 p.Ser15Phe Uncertain significance Single submitter
- IGSF11 p.Ser234Thr Uncertain significance Single submitter
- IGSF11 p.Ser304Tyr Uncertain significance Single submitter
- IGSF11 p.Ser306Leu Uncertain significance Single submitter
- IGSF11 p.Ser346Cys Uncertain significance Single submitter
- IGSF11 p.Thr110Pro Uncertain significance Single submitter
- IGSF11 p.Thr192Ile Uncertain significance Single submitter
- IGSF11 p.Thr2Ile Uncertain significance Single submitter
- IGSF11 p.Thr2Pro Uncertain significance Single submitter
- IGSF11 p.Thr47Ile Uncertain significance Single submitter
- IGSF11 p.Val122Ala Uncertain significance Single submitter
- IGSF11 p.Val365Ala Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- IGSF11 p.Ala416Val Uncertain significance Single submitter
- IGSF11 p.Arg87Trp Uncertain significance Single submitter
- IGSF11 p.Glu286Gly Uncertain significance Single submitter
- IGSF11 p.Gly129Arg Uncertain significance Single submitter
- IGSF11 p.Gly428Arg Uncertain significance Single submitter
- IGSF11 p.Ile32Met Uncertain significance Single submitter
- IGSF11 p.Pro418Arg Uncertain significance Single submitter
- IGSF11 p.Thr410Pro Uncertain significance Single submitter
- IGSF11 p.Trp268Arg Uncertain significance Single submitter
All IGSF11 variants
Uncertain significance 53
- p.Ala352Val Single submitter ⚠
- p.Ala409Thr Single submitter ⚠
- p.Ala416Val Single submitter ⚠
- p.Arg203Trp Single submitter
- p.Arg320Gln Single submitter ⚠
- p.Arg387Gly Single submitter ⚠
- p.Arg5Cys Single submitter ⚠
- p.Arg5Ser Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asn315Ser Single submitter ⚠
- p.Asn325Ser Single submitter ⚠
- p.Asn353Ile Single submitter ⚠
- p.Asn56Ser Single submitter ⚠
- p.Asp114Ala Single submitter ⚠
- p.Cys293Gly Single submitter ⚠
- p.Gln343Pro Single submitter ⚠
- p.Glu286Gly Single submitter ⚠
- p.Gly129Ala Single submitter ⚠
- p.Gly129Arg Single submitter ⚠
- p.Gly130Asp Single submitter
- p.Gly250Asp Single submitter ⚠
- p.Gly379Arg Single submitter ⚠
- p.Gly390Ala Single submitter ⚠
- p.Gly428Arg Single submitter ⚠
- p.Gly90Ser Single submitter ⚠
- p.His369Arg Single submitter ⚠
- p.Ile261Leu Single submitter ⚠
- p.Ile32Met Single submitter ⚠
- p.Ile414Phe Single submitter ⚠
- p.Ile53Val Single submitter ⚠
- p.Leu164Phe Single submitter ⚠
- p.Leu6Phe Single submitter
- p.Lys271Asn Single submitter
- p.Lys297Arg Single submitter ⚠
- p.Met81Val Single submitter ⚠
- p.Phe347Ile Single submitter ⚠
- p.Phe347Tyr Single submitter ⚠
- p.Pro396Leu Single submitter ⚠
- p.Pro418Arg Single submitter ⚠
- p.Ser15Phe Single submitter ⚠
- p.Ser234Thr Single submitter ⚠
- p.Ser304Tyr Single submitter ⚠
- p.Ser306Leu Single submitter ⚠
- p.Ser346Cys Single submitter ⚠
- p.Thr110Pro Single submitter ⚠
- p.Thr192Ile Single submitter ⚠
- p.Thr2Ile Single submitter ⚠
- p.Thr2Pro Single submitter ⚠
- p.Thr410Pro Single submitter ⚠
- p.Thr47Ile Single submitter ⚠
- p.Trp268Arg Single submitter ⚠
- p.Val122Ala Single submitter ⚠
- p.Val365Ala Single submitter ⚠