Sugi Variant

Sugi Variant/IL10RA

IL10RA — 484 ClinVar variants

All ClinVar germline IL10RA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 195 flagged for review →

15 Pathogenic · 3 Pathogenic/Likely pathogenic · 5 Likely pathogenic · 33 Conflicting · 7 Benign · 23 Benign/Likely benign · 178 Likely benign · 220 Uncertain significance

Full IL10RA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 195

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 15

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 162

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 162

Predictors split 17

The independent predictors disagree with each other — read with care.

All IL10RA variants

Pathogenic 15

  • p.Arg117Cys Multiple submitters inflammatory bowel disease 28
  • p.Arg212Ter Multiple submitters inflammatory bowel disease 28
  • p.Arg147fs Single submitter inflammatory bowel disease 28
  • p.Arg262Cys Single submitter inflammatory bowel disease 28 ⚠
  • p.Asn94fs Single submitter inflammatory bowel disease 28
  • p.Gln257Ter Single submitter inflammatory bowel disease 28
  • p.Ile169Thr Single submitter inflammatory bowel disease 28
  • p.Met1Ile Single submitter inflammatory bowel disease 28
  • p.Pro207fs Single submitter inflammatory bowel disease 28
  • p.Trp33Ter Single submitter inflammatory bowel disease 28
  • p.Tyr157Cys Single submitter inflammatory bowel disease 28
  • p.Tyr167Ter Single submitter inflammatory bowel disease 28
  • p.Tyr252Ter Single submitter inflammatory bowel disease 28
  • p.Gly141Arg No assertion criteria inflammatory bowel disease 28
  • p.Thr84Ile No assertion criteria inflammatory bowel disease 28

Pathogenic/Likely pathogenic 3

  • p.Arg101Trp Multiple submitters IL10RA-related disorder
  • p.Arg165Ter Multiple submitters inflammatory bowel disease 28
  • p.Thr179= Multiple submitters inflammatory bowel disease 28

Likely pathogenic 5

  • c.68-1G>A Multiple submitters IL10RA-related disorder
  • c.67+1G>A Single submitter inflammatory bowel disease 28
  • c.688+2T>C Single submitter IL10RA-related disorder
  • p.Arg263Ter Single submitter inflammatory bowel disease 28
  • p.Leu43fs Single submitter inflammatory bowel disease 28

Conflicting classifications of pathogenicity 33

  • c.67+10C>T Single submitter inflammatory bowel disease 28
  • c.67+11G>A Single submitter inflammatory bowel disease 28
  • c.67+11G>C Single submitter inflammatory bowel disease 28
  • c.67+13G>A Single submitter inflammatory bowel disease 28
  • c.67+15C>T Single submitter inflammatory bowel disease 28
  • c.67+8T>C Single submitter inflammatory bowel disease 28
  • p.Ala511Thr Single submitter Inborn genetic diseases ⚠
  • p.Arg101= Single submitter inflammatory bowel disease 28
  • p.Arg101Gln Single submitter inflammatory bowel disease 28 ⚠
  • p.Arg107Gln Single submitter inflammatory bowel disease 28 ⚠
  • p.Arg261Trp Single submitter inflammatory bowel disease 28 ⚠
  • p.Arg412Gln Single submitter inflammatory bowel disease 28 ⚠
  • p.Asp358Asn Single submitter inflammatory bowel disease 28 ⚠
  • p.Glu484= Single submitter inflammatory bowel disease 28
  • p.Gly248Arg Single submitter inflammatory bowel disease 28 ⚠
  • p.Leu311= Single submitter inflammatory bowel disease 28
  • p.Lys149= Single submitter inflammatory bowel disease 28
  • p.Pro295Leu Single submitter inflammatory bowel disease 28 ⚠
  • p.Pro30Leu Single submitter inflammatory bowel disease 28 ⚠
  • p.Pro353Ser Single submitter IL10RA-related disorder ⚠
  • p.Pro427= Single submitter inflammatory bowel disease 28
  • p.Pro428Leu Single submitter inflammatory bowel disease 28 ⚠
  • p.Ser420= Single submitter inflammatory bowel disease 28
  • p.Ser467= Single submitter inflammatory bowel disease 28
  • p.Ser467Leu Single submitter inflammatory bowel disease 28 ⚠
  • p.Ser532Gly Single submitter Inborn genetic diseases ⚠
  • p.Thr24= Single submitter inflammatory bowel disease 28
  • p.Thr513= Single submitter Inborn genetic diseases
  • p.Tyr57Cys Single submitter IL10RA-related disorder ⚠
  • p.Val233Gly Single submitter inflammatory bowel disease 28 ⚠
  • p.Val32= Single submitter inflammatory bowel disease 28
  • p.Val355Glu Single submitter Inborn genetic diseases ⚠
  • p.Val441= Single submitter inflammatory bowel disease 28

Benign 7

  • c.*1348G>C Multiple submitters inflammatory bowel disease 28
  • c.*1730G>A Multiple submitters inflammatory bowel disease 28
  • c.*354T>C Multiple submitters inflammatory bowel disease 28
  • c.67+89G>C Single submitter
  • c.68-114G>A Single submitter
  • c.*1412T>C Single submitter inflammatory bowel disease 28
  • c.*968G>A Single submitter inflammatory bowel disease 28

Benign/Likely benign 23

  • c.368-18C>A Multiple submitters inflammatory bowel disease 28
  • c.368-18C>G Multiple submitters inflammatory bowel disease 28
  • c.68-16A>G Multiple submitters inflammatory bowel disease 28
  • c.810+10G>A Multiple submitters inflammatory bowel disease 28
  • p.Ala153= Multiple submitters inflammatory bowel disease 28
  • p.Ala546= Multiple submitters inflammatory bowel disease 28
  • p.Ala60= Multiple submitters inflammatory bowel disease 28
  • p.Arg396= Multiple submitters inflammatory bowel disease 28
  • p.Asp104= Multiple submitters inflammatory bowel disease 28
  • p.Glu25Asp Multiple submitters inflammatory bowel disease 28
  • p.Glu454Lys Multiple submitters inflammatory bowel disease 28
  • p.Ile224Val Multiple submitters inflammatory bowel disease 28
  • p.Ile48= Multiple submitters inflammatory bowel disease 28
  • p.Leu61Val Multiple submitters inflammatory bowel disease 28
  • p.Phe239Ser Multiple submitters inflammatory bowel disease 28
  • p.Pro175= Multiple submitters inflammatory bowel disease 28
  • p.Ser159Gly Multiple submitters inflammatory bowel disease 28
  • p.Ser420Leu Multiple submitters inflammatory bowel disease 28
  • p.Thr232= Multiple submitters inflammatory bowel disease 28
  • p.Thr347= Multiple submitters inflammatory bowel disease 28
  • p.Thr46Ala Multiple submitters inflammatory bowel disease 28
  • p.Val113Ile Multiple submitters inflammatory bowel disease 28
  • p.Val233Met Multiple submitters inflammatory bowel disease 28

Likely benign 178

  • c.188+18G>A Multiple submitters inflammatory bowel disease 28
  • c.368-18C>T Multiple submitters inflammatory bowel disease 28
  • c.368-20C>A Multiple submitters inflammatory bowel disease 28
  • c.368-20C>G Multiple submitters inflammatory bowel disease 28
  • c.811-9C>T Multiple submitters inflammatory bowel disease 28
  • p.Asn94= Multiple submitters inflammatory bowel disease 28
  • p.Asp399= Multiple submitters inflammatory bowel disease 28
  • p.Glu578= Multiple submitters inflammatory bowel disease 28
  • p.Glu58Lys Multiple submitters inflammatory bowel disease 28
  • p.Leu140= Multiple submitters inflammatory bowel disease 28
  • p.Leu254= Multiple submitters inflammatory bowel disease 28
  • p.Leu313= Multiple submitters inflammatory bowel disease 28
  • p.Leu574= Multiple submitters inflammatory bowel disease 28
  • p.Pro295= Multiple submitters inflammatory bowel disease 28
  • p.Pro30= Multiple submitters inflammatory bowel disease 28
  • p.Pro333= Multiple submitters inflammatory bowel disease 28
  • p.Pro342= Multiple submitters inflammatory bowel disease 28
  • p.Pro3Gln Multiple submitters inflammatory bowel disease 28
  • p.Ser106= Multiple submitters inflammatory bowel disease 28
  • p.Ser211= Multiple submitters inflammatory bowel disease 28
  • p.Ser247= Multiple submitters inflammatory bowel disease 28
  • p.Thr324= Multiple submitters inflammatory bowel disease 28
  • c.188+11G>A Single submitter inflammatory bowel disease 28
  • c.188+12G>A Single submitter
  • c.188+14A>G Single submitter inflammatory bowel disease 28
  • c.189-11T>G Single submitter inflammatory bowel disease 28
  • c.189-12G>C Single submitter inflammatory bowel disease 28
  • c.367+10C>T Single submitter inflammatory bowel disease 28
  • c.367+10del Single submitter inflammatory bowel disease 28
  • c.367+11T>A Single submitter
  • c.367+12C>G Single submitter inflammatory bowel disease 28
  • c.367+12C>T Single submitter inflammatory bowel disease 28
  • c.367+20T>G Single submitter inflammatory bowel disease 28
  • c.368-16C>A Single submitter inflammatory bowel disease 28
  • c.368-20C>T Single submitter inflammatory bowel disease 28
  • c.537+12C>T Single submitter inflammatory bowel disease 28
  • c.537+13C>G Single submitter inflammatory bowel disease 28
  • c.537+16A>G Single submitter inflammatory bowel disease 28
  • c.537+17G>T Single submitter inflammatory bowel disease 28
  • c.537+18G>T Single submitter inflammatory bowel disease 28
  • c.537+20C>G Single submitter inflammatory bowel disease 28
  • c.537+7_537+10dup Single submitter inflammatory bowel disease 28
  • c.537+9T>C Single submitter inflammatory bowel disease 28
  • c.538-10T>G Single submitter inflammatory bowel disease 28
  • c.538-11T>A Single submitter inflammatory bowel disease 28
  • c.538-14C>A Single submitter inflammatory bowel disease 28
  • c.538-20T>C Single submitter inflammatory bowel disease 28
  • c.538-9T>C Single submitter inflammatory bowel disease 28
  • c.67+139C>T Single submitter
  • c.67+17C>G Single submitter inflammatory bowel disease 28
  • c.67+17C>T Single submitter inflammatory bowel disease 28
  • c.67+20C>A Single submitter
  • c.67+20C>T Single submitter inflammatory bowel disease 28
  • c.68-6C>T Single submitter inflammatory bowel disease 28
  • c.688+17G>A Single submitter inflammatory bowel disease 28
  • c.689-14C>T Single submitter inflammatory bowel disease 28
  • c.689-18A>T Single submitter inflammatory bowel disease 28
  • c.689-8G>A Single submitter inflammatory bowel disease 28
  • c.689-8G>T Single submitter inflammatory bowel disease 28
  • c.810+11C>T Single submitter inflammatory bowel disease 28
  • c.810+17G>A Single submitter inflammatory bowel disease 28
  • c.810+19_810+24del Single submitter inflammatory bowel disease 28
  • c.811-11C>G Single submitter inflammatory bowel disease 28
  • c.811-13C>T Single submitter inflammatory bowel disease 28
  • c.811-15C>T Single submitter inflammatory bowel disease 28
  • c.*133C>T Single submitter inflammatory bowel disease 28
  • c.*1352G>A Single submitter inflammatory bowel disease 28
  • c.*3C>T Single submitter
  • c.*756T>C Single submitter inflammatory bowel disease 28
  • c.*984C>A Single submitter inflammatory bowel disease 28
  • p.Ala10= Single submitter inflammatory bowel disease 28
  • p.Ala21= Single submitter inflammatory bowel disease 28
  • p.Ala241= Single submitter inflammatory bowel disease 28
  • p.Ala413= Single submitter inflammatory bowel disease 28
  • p.Ala421= Single submitter inflammatory bowel disease 28
  • p.Ala442= Single submitter inflammatory bowel disease 28
  • p.Arg107= Single submitter inflammatory bowel disease 28
  • p.Arg165= Single submitter inflammatory bowel disease 28
  • p.Arg228= Single submitter inflammatory bowel disease 28
  • p.Arg263= Single submitter inflammatory bowel disease 28
  • p.Arg346= Single submitter inflammatory bowel disease 28
  • p.Arg351Gly Single submitter inflammatory bowel disease 28
  • p.Asn235= Single submitter inflammatory bowel disease 28
  • p.Asn350= Single submitter
  • p.Asn394= Single submitter inflammatory bowel disease 28
  • p.Asn517= Single submitter inflammatory bowel disease 28
  • p.Asp155= Single submitter inflammatory bowel disease 28
  • p.Asp312= Single submitter inflammatory bowel disease 28
  • p.Asp318= Single submitter inflammatory bowel disease 28
  • p.Asp400= Single submitter
  • p.Asp89= Single submitter inflammatory bowel disease 28
  • p.Cys202= Single submitter inflammatory bowel disease 28
  • p.Gln283= Single submitter inflammatory bowel disease 28
  • p.Gln398= Single submitter inflammatory bowel disease 28
  • p.Glu158= Single submitter inflammatory bowel disease 28
  • p.Glu464= Single submitter inflammatory bowel disease 28
  • p.Gly141= Single submitter inflammatory bowel disease 28
  • p.Gly349= Single submitter inflammatory bowel disease 28
  • p.Gly371= Single submitter inflammatory bowel disease 28
  • p.Gly402= Single submitter inflammatory bowel disease 28
  • p.Gly472= Single submitter inflammatory bowel disease 28
  • p.Gly472Asp Single submitter inflammatory bowel disease 28
  • p.Gly486= Single submitter inflammatory bowel disease 28
  • p.His314= Single submitter inflammatory bowel disease 28
  • p.His40= Single submitter inflammatory bowel disease 28
  • p.His424= Single submitter inflammatory bowel disease 28
  • p.His44= Single submitter inflammatory bowel disease 28
  • p.Ile42= Single submitter inflammatory bowel disease 28
  • p.Ile72= Single submitter inflammatory bowel disease 28
  • p.Leu132= Single submitter inflammatory bowel disease 28
  • p.Leu15= Single submitter inflammatory bowel disease 28
  • p.Leu226= Single submitter inflammatory bowel disease 28
  • p.Leu250= Single submitter inflammatory bowel disease 28
  • p.Leu266= Single submitter inflammatory bowel disease 28
  • p.Leu271= Single submitter inflammatory bowel disease 28
  • p.Leu348= Single submitter inflammatory bowel disease 28
  • p.Leu356= Single submitter inflammatory bowel disease 28
  • p.Leu447= Single submitter inflammatory bowel disease 28
  • p.Leu473= Single submitter inflammatory bowel disease 28
  • p.Leu481= Single submitter inflammatory bowel disease 28
  • p.Leu502= Single submitter
  • p.Leu506= Single submitter inflammatory bowel disease 28
  • p.Leu545= Single submitter inflammatory bowel disease 28
  • p.Leu557= Single submitter inflammatory bowel disease 28
  • p.Leu565= Single submitter inflammatory bowel disease 28
  • p.Leu568= Single submitter inflammatory bowel disease 28
  • p.Leu570= Single submitter inflammatory bowel disease 28
  • p.Leu79= Single submitter inflammatory bowel disease 28
  • p.Leu88= Single submitter inflammatory bowel disease 28
  • p.Lys220= Single submitter inflammatory bowel disease 28
  • p.Lys264= Single submitter inflammatory bowel disease 28
  • p.Lys309= Single submitter inflammatory bowel disease 28
  • p.Lys459= Single submitter inflammatory bowel disease 28
  • p.Lys494= Single submitter inflammatory bowel disease 28
  • p.Phe180= Single submitter
  • p.Phe239= Single submitter inflammatory bowel disease 28
  • p.Phe477= Single submitter inflammatory bowel disease 28
  • p.Pro152= Single submitter inflammatory bowel disease 28
  • p.Pro27= Single submitter inflammatory bowel disease 28
  • p.Pro287= Single submitter inflammatory bowel disease 28
  • p.Pro29= Single submitter inflammatory bowel disease 28
  • p.Pro428= Single submitter inflammatory bowel disease 28
  • p.Pro433= Single submitter inflammatory bowel disease 28
  • p.Pro468= Single submitter inflammatory bowel disease 28
  • p.Ser159= Single submitter inflammatory bowel disease 28
  • p.Ser268= Single submitter inflammatory bowel disease 28
  • p.Ser31= Single submitter inflammatory bowel disease 28
  • p.Ser365= Single submitter inflammatory bowel disease 28
  • p.Ser370= Single submitter inflammatory bowel disease 28
  • p.Ser380= Single submitter inflammatory bowel disease 28
  • p.Ser401= Single submitter inflammatory bowel disease 28
  • p.Ser540= Single submitter inflammatory bowel disease 28
  • p.Ser563= Single submitter inflammatory bowel disease 28
  • p.Ser572= Single submitter inflammatory bowel disease 28
  • p.Ser73= Single submitter inflammatory bowel disease 28
  • p.Thr112= Single submitter inflammatory bowel disease 28
  • p.Thr126= Single submitter inflammatory bowel disease 28
  • p.Thr194= Single submitter inflammatory bowel disease 28
  • p.Thr234= Single submitter inflammatory bowel disease 28
  • p.Thr383= Single submitter inflammatory bowel disease 28
  • p.Thr386= Single submitter inflammatory bowel disease 28
  • p.Thr416= Single submitter inflammatory bowel disease 28
  • p.Thr450= Single submitter inflammatory bowel disease 28
  • p.Thr46= Single submitter inflammatory bowel disease 28
  • p.Thr567= Single submitter inflammatory bowel disease 28
  • p.Thr84= Single submitter inflammatory bowel disease 28
  • p.Tyr446= Single submitter inflammatory bowel disease 28
  • p.Val100= Single submitter inflammatory bowel disease 28
  • p.Val123= Single submitter inflammatory bowel disease 28
  • p.Val185= Single submitter inflammatory bowel disease 28
  • p.Val198= Single submitter inflammatory bowel disease 28
  • p.Val209= Single submitter inflammatory bowel disease 28
  • p.Val391= Single submitter inflammatory bowel disease 28
  • p.Val432= Single submitter inflammatory bowel disease 28
  • p.Val482= Single submitter inflammatory bowel disease 28
  • p.Val59= Single submitter inflammatory bowel disease 28
  • p.Val7= Single submitter inflammatory bowel disease 28
  • c.67+8T>G No assertion criteria IL10RA-related disorder

Uncertain significance 220