Sugi Variant

Sugi Variant/IL10RB

IL10RB — 94 ClinVar variants

All ClinVar germline IL10RB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →

3 Pathogenic · 2 Likely pathogenic · 4 Conflicting · 6 Benign · 2 Benign/Likely benign · 38 Likely benign · 39 Uncertain significance

Full IL10RB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 34

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 27

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 4

The independent predictors disagree with each other — read with care.

All IL10RB variants

Pathogenic 3

  • p.Tyr56Ter Single submitter inflammatory bowel disease 25
  • p.Glu141Ter No assertion criteria inflammatory bowel disease 25
  • p.Trp100Ter No assertion criteria inflammatory bowel disease 25

Likely pathogenic 2

  • c.331+1G>A Single submitter inflammatory bowel disease 25
  • c.49+2T>G Single submitter inflammatory bowel disease 25

Conflicting classifications of pathogenicity 4

Benign 6

  • c.*135G>A Multiple submitters inflammatory bowel disease 25
  • c.*314G>A Multiple submitters inflammatory bowel disease 25
  • c.*85A>G Multiple submitters inflammatory bowel disease 25
  • c.805-591T>G Single submitter
  • c.805-886C>A Single submitter
  • c.*334G>A Single submitter inflammatory bowel disease 25

Benign/Likely benign 2

  • c.646+19C>A Multiple submitters inflammatory bowel disease 25
  • p.Lys47Glu Multiple submitters inflammatory bowel disease 25

Likely benign 38

  • c.332-5del Multiple submitters inflammatory bowel disease 25
  • c.-72C>A Multiple submitters inflammatory bowel disease 25
  • p.Glu210= Multiple submitters inflammatory bowel disease 25
  • c.173+14C>T Single submitter inflammatory bowel disease 25
  • c.173+8T>C Single submitter inflammatory bowel disease 25
  • c.332-11C>G Single submitter inflammatory bowel disease 25
  • c.332-17del Single submitter inflammatory bowel disease 25
  • c.332-3dup Single submitter inflammatory bowel disease 25
  • c.49+14G>A Single submitter inflammatory bowel disease 25
  • c.49+19G>A Single submitter inflammatory bowel disease 25
  • c.498+19A>G Single submitter inflammatory bowel disease 25
  • c.499-14G>T Single submitter inflammatory bowel disease 25
  • c.50-4A>G Single submitter inflammatory bowel disease 25
  • c.646+16C>T Single submitter inflammatory bowel disease 25
  • c.647-16C>G Single submitter inflammatory bowel disease 25
  • c.647-17C>T Single submitter inflammatory bowel disease 25
  • p.Asn150= Single submitter inflammatory bowel disease 25
  • p.Gln55= Single submitter inflammatory bowel disease 25
  • p.Gly48= Single submitter inflammatory bowel disease 25
  • p.His275= Single submitter inflammatory bowel disease 25
  • p.Leu14= Single submitter inflammatory bowel disease 25
  • p.Leu239= Single submitter inflammatory bowel disease 25
  • p.Leu266= Single submitter inflammatory bowel disease 25
  • p.Leu278= Single submitter inflammatory bowel disease 25
  • p.Leu295= Single submitter inflammatory bowel disease 25
  • p.Leu9= Single submitter inflammatory bowel disease 25
  • p.Phe242= Single submitter inflammatory bowel disease 25
  • p.Phe256= Single submitter inflammatory bowel disease 25
  • p.Pro196= Single submitter inflammatory bowel disease 25
  • p.Pro23= Single submitter inflammatory bowel disease 25
  • p.Ser304= Single submitter inflammatory bowel disease 25
  • p.Thr104= Single submitter inflammatory bowel disease 25
  • p.Thr212= Single submitter inflammatory bowel disease 25
  • p.Thr277= Single submitter inflammatory bowel disease 25
  • p.Tyr187= Single submitter inflammatory bowel disease 25
  • p.Tyr254= Single submitter inflammatory bowel disease 25
  • p.Tyr59= Single submitter inflammatory bowel disease 25
  • p.Val234= Single submitter inflammatory bowel disease 25

Uncertain significance 39