IL15 — 16 ClinVar variants
All ClinVar germline IL15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
1 Benign · 1 Likely benign · 14 Uncertain significance
Full IL15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL15 p.Ala29Gly Uncertain significance Single submitter
- IL15 p.Asp78Glu Uncertain significance Single submitter
- IL15 p.Glu146Gln Uncertain significance Single submitter
- IL15 p.His32Arg Uncertain significance Single submitter
- IL15 p.His80Tyr Uncertain significance Single submitter
- IL15 p.Ile144Phe Uncertain significance Single submitter
- IL15 p.Leu73Ser Uncertain significance Single submitter
- IL15 p.Leu8Val Uncertain significance Single submitter
- IL15 p.Phe39Leu Uncertain significance Single submitter
- IL15 p.Pro44Thr Uncertain significance Single submitter
- IL15 p.Pro6Ala Uncertain significance Single submitter
- IL15 p.Ser121Arg Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All IL15 variants
Benign 1
- p.Leu117= Multiple submitters
Likely benign 1
- p.Cys136= Multiple submitters
Uncertain significance 14
- p.Ala29Gly Single submitter ⚠
- p.Asp78Glu Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.His32Arg Single submitter ⚠
- p.His80Tyr Single submitter ⚠
- p.Ile144Phe Single submitter ⚠
- p.Leu73Ser Single submitter ⚠
- p.Leu8Val Single submitter ⚠
- p.Phe39Leu Single submitter ⚠
- p.Pro44Thr Single submitter ⚠
- p.Pro6Ala Single submitter ⚠
- p.Ser121Arg Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Trp50Leu Single submitter ⚠