IL15RA — 48 ClinVar variants

All ClinVar germline IL15RA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →

3 Benign · 1 Benign/Likely benign · 10 Likely benign · 34 Uncertain significance

Full IL15RA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 34

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 31

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 3

The independent predictors disagree with each other — read with care.

All IL15RA variants

Benign 3

p.Asn182Thr Multiple submitters
p.Thr111Met Multiple submitters
p.Val239Ile Multiple submitters

Benign/Likely benign 1

p.Ser171= Multiple submitters

Likely benign 10

p.Gly5= Multiple submitters
p.Ala105Val Single submitter
p.Ala140Val Single submitter
p.Gly173Ala Single submitter
p.Met37Thr Single submitter
p.Pro134Ser Single submitter
p.Pro234Ser Single submitter
p.Ser170Pro Single submitter
p.Ser188= Single submitter
p.Thr250= Single submitter

Uncertain significance 34

p.Ala141Thr Single submitter ⚠
p.Ala80Ser Single submitter ⚠
p.Ala84Thr Single submitter ⚠
p.Arg4Gln Single submitter ⚠
p.Arg7Cys Single submitter ⚠
p.Asp96His Single submitter ⚠
p.Cys216Gly Single submitter ⚠
p.Cys59Tyr Single submitter ⚠
p.Glu164Lys Single submitter ⚠
p.Glu169Gly Single submitter ⚠
p.Glu74Asp Single submitter ⚠
p.Gly68Ser Single submitter ⚠
p.Leu122Phe Single submitter ⚠
p.Leu20Pro Single submitter ⚠
p.Leu22Gln Single submitter ⚠
p.Pro104Ser Single submitter ⚠
p.Pro124Ser Single submitter ⚠
p.Pro148Leu Single submitter ⚠
p.Pro175Arg Single submitter ⚠
p.Pro235Leu Single submitter ⚠
p.Pro25Leu Single submitter ⚠
p.Pro36Thr Single submitter ⚠
p.Pro3Leu Single submitter ⚠
p.Ser121Gly Single submitter ⚠
p.Ser135Arg Single submitter ⚠
p.Ser222Phe Single submitter ⚠
p.Ser53Phe Single submitter ⚠
p.Thr139Ile Single submitter ⚠
p.Thr143Ala Single submitter ⚠
p.Thr174Asn Single submitter ⚠
p.Thr210Met Single submitter ⚠
p.Thr250Ile Single submitter ⚠
p.Thr81Met Single submitter ⚠
p.Val221Met Single submitter ⚠