IL17A — 30 ClinVar variants
All ClinVar germline IL17A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
5 Benign · 1 Likely benign · 24 Uncertain significance
Full IL17A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL17A p.Ala102Pro Uncertain significance Single submitter
- IL17A p.Arg29Gly Uncertain significance Single submitter
- IL17A p.Arg78His Uncertain significance Single submitter
- IL17A p.Arg95Pro Uncertain significance Single submitter
- IL17A p.Asn101Ile Uncertain significance Single submitter
- IL17A p.Asn79Ser Uncertain significance Single submitter
- IL17A p.Asp65Gly Uncertain significance Single submitter
- IL17A p.Glu37Lys Uncertain significance Single submitter
- IL17A p.Glu91Lys Uncertain significance Single submitter
- IL17A p.His152Gln Uncertain significance Single submitter
- IL17A p.Ile119Val Uncertain significance Single submitter
- IL17A p.Ile27Val Uncertain significance Single submitter
- IL17A p.Met46Ile Uncertain significance Single submitter
- IL17A p.Pro114Ala Uncertain significance Single submitter
- IL17A p.Pro126Thr Uncertain significance Single submitter
- IL17A p.Pro82Thr Uncertain significance Single submitter
- IL17A p.Val9Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- IL17A p.Arg134Trp Uncertain significance Single submitter
- IL17A p.Arg69Gln Uncertain significance Single submitter
- IL17A p.Asn48Ile Uncertain significance Single submitter
- IL17A p.Glu91Asp Uncertain significance Single submitter
- IL17A p.Leu120Val Uncertain significance Single submitter
- IL17A p.Leu139Pro Uncertain significance Single submitter
- IL17A p.Ser16Arg Uncertain significance Single submitter
All IL17A variants
Benign 5
- c.27+18G>A Multiple submitters
- c.231-257T>C Single submitter
- c.*1249C>T Single submitter
- c.*159G>A Single submitter
- p.Arg134= Single submitter
Likely benign 1
- p.Arg43Gln Single submitter
Uncertain significance 24
- p.Ala102Pro Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg78His Single submitter ⚠
- p.Arg95Pro Single submitter ⚠
- p.Asn101Ile Single submitter ⚠
- p.Asn48Ile Single submitter ⚠
- p.Asn79Ser Single submitter ⚠
- p.Asp65Gly Single submitter ⚠
- p.Glu37Lys Single submitter ⚠
- p.Glu91Asp Single submitter ⚠
- p.Glu91Lys Single submitter ⚠
- p.His152Gln Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Leu120Val Single submitter ⚠
- p.Leu139Pro Single submitter ⚠
- p.Met46Ile Single submitter ⚠
- p.Pro114Ala Single submitter ⚠
- p.Pro126Thr Single submitter ⚠
- p.Pro82Thr Single submitter ⚠
- p.Ser16Arg Single submitter ⚠
- p.Val9Ala Single submitter ⚠