Sugi Variant

Sugi Variant/IL17F

IL17F — 169 ClinVar variants

All ClinVar germline IL17F variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →

12 Conflicting · 9 Benign · 2 Benign/Likely benign · 48 Likely benign · 98 Uncertain significance

Full IL17F gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 85

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 67

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 12

The independent predictors disagree with each other — read with care.

All IL17F variants

Conflicting classifications of pathogenicity 12

Benign 9

Benign/Likely benign 2

  • p.Gly106= Multiple submitters candidiasis, familial, 6
  • p.Ile74= Multiple submitters candidiasis, familial, 6

Likely benign 48

  • p.Gly151= Multiple submitters candidiasis, familial, 6
  • p.Ser120= Multiple submitters candidiasis, familial, 6
  • c.254+5G>C Single submitter candidiasis, familial, 6
  • c.255-5T>C Single submitter candidiasis, familial, 6
  • c.255-6C>T Single submitter candidiasis, familial, 6
  • c.255-7C>T Single submitter candidiasis, familial, 6
  • c.255-9C>T Single submitter candidiasis, familial, 6
  • c.33+12C>T Single submitter candidiasis, familial, 6
  • c.34-16G>A Single submitter candidiasis, familial, 6
  • c.34-17C>T Single submitter candidiasis, familial, 6
  • p.Arg67= Single submitter candidiasis, familial, 6
  • p.Arg92= Single submitter candidiasis, familial, 6
  • p.Asn91= Single submitter candidiasis, familial, 6
  • p.Asp115= Single submitter candidiasis, familial, 6
  • p.Asp58= Single submitter candidiasis, familial, 6
  • p.Cys137= Single submitter candidiasis, familial, 6
  • p.Cys154= Single submitter candidiasis, familial, 6
  • p.Gln125= Single submitter candidiasis, familial, 6
  • p.Glu96= Single submitter candidiasis, familial, 6
  • p.Gly37= Single submitter candidiasis, familial, 6
  • p.Gly53= Single submitter candidiasis, familial, 6
  • p.Gly60= Single submitter candidiasis, familial, 6
  • p.His160Arg Single submitter
  • p.His161= Single submitter candidiasis, familial, 6
  • p.His38= Single submitter candidiasis, familial, 6
  • p.His7= Single submitter candidiasis, familial, 6
  • p.Ile159= Single submitter candidiasis, familial, 6
  • p.Ile59= Single submitter candidiasis, familial, 6
  • p.Leu105= Single submitter candidiasis, familial, 6
  • p.Leu20= Single submitter candidiasis, familial, 6
  • p.Leu22= Single submitter
  • p.Lys113= Single submitter candidiasis, familial, 6
  • p.Lys13= Single submitter candidiasis, familial, 6
  • p.Lys32= Single submitter candidiasis, familial, 6
  • p.Pro34= Single submitter candidiasis, familial, 6
  • p.Pro48= Single submitter candidiasis, familial, 6
  • p.Pro90= Single submitter candidiasis, familial, 6
  • p.Ser117= Single submitter candidiasis, familial, 6
  • p.Ser18= Single submitter candidiasis, familial, 6
  • p.Ser80= Single submitter candidiasis, familial, 6
  • p.Thr149= Single submitter candidiasis, familial, 6
  • p.Thr153= Single submitter candidiasis, familial, 6
  • p.Thr5= Single submitter candidiasis, familial, 6
  • p.Tyr14= Single submitter candidiasis, familial, 6
  • p.Val129= Single submitter candidiasis, familial, 6
  • p.Val158= Single submitter candidiasis, familial, 6
  • p.Val86= Single submitter candidiasis, familial, 6
  • p.Val97= Single submitter candidiasis, familial, 6

Uncertain significance 98