Sugi Variant

Sugi Variant/IL17RC

IL17RC — 868 ClinVar variants

All ClinVar germline IL17RC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 419 flagged for review →

1 Pathogenic · 5 Likely pathogenic · 22 Conflicting · 21 Benign · 19 Benign/Likely benign · 320 Likely benign · 480 Uncertain significance

Full IL17RC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 419

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 16

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 335

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 335

Predictors split 68

The independent predictors disagree with each other — read with care.

All IL17RC variants

Pathogenic 1

  • p.Gln67Ter No assertion criteria candidiasis, familial, 9

Likely pathogenic 5

Conflicting classifications of pathogenicity 22

Benign 21

Benign/Likely benign 19

  • c.105+24C>T Multiple submitters candidiasis, familial, 9
  • c.105+62G>A Multiple submitters candidiasis, familial, 9
  • c.1522+1G>C Multiple submitters candidiasis, familial, 9
  • c.466-18T>C Multiple submitters candidiasis, familial, 9
  • c.877+11C>T Multiple submitters candidiasis, familial, 9
  • c.878-16T>C Multiple submitters candidiasis, familial, 9
  • p.Ala326Val Multiple submitters candidiasis, familial, 9
  • p.Ala454= Multiple submitters candidiasis, familial, 9
  • p.Ala565= Multiple submitters candidiasis, familial, 9
  • p.Ala62= Multiple submitters candidiasis, familial, 9
  • p.Asn349= Multiple submitters candidiasis, familial, 9
  • p.Gln258His Multiple submitters candidiasis, familial, 9
  • p.Gln307Arg Multiple submitters candidiasis, familial, 9
  • p.Gly389= Multiple submitters candidiasis, familial, 9
  • p.Gly711= Multiple submitters candidiasis, familial, 9
  • p.Leu554Val Multiple submitters candidiasis, familial, 9
  • p.Pro4= Multiple submitters candidiasis, familial, 9
  • p.Ser111Leu Multiple submitters candidiasis, familial, 9
  • p.Val560= Multiple submitters candidiasis, familial, 9

Likely benign 320

Showing the top 300 by review status; the full set is in the sitemap.

  • c.105+12A>G Multiple submitters candidiasis, familial, 9
  • c.1059+20C>T Multiple submitters candidiasis, familial, 9
  • c.1060-12C>T Multiple submitters candidiasis, familial, 9
  • c.1278+13C>T Multiple submitters candidiasis, familial, 9
  • c.1278+14G>A Multiple submitters candidiasis, familial, 9
  • c.1483+16C>A Multiple submitters candidiasis, familial, 9
  • c.1483+7G>T Multiple submitters candidiasis, familial, 9
  • c.281-7C>T Multiple submitters candidiasis, familial, 9
  • c.577+15A>G Multiple submitters candidiasis, familial, 9
  • c.823-9C>T Multiple submitters candidiasis, familial, 9
  • c.878-7C>T Multiple submitters candidiasis, familial, 9
  • p.Ala303= Multiple submitters candidiasis, familial, 9
  • p.Ala326= Multiple submitters candidiasis, familial, 9
  • p.Ala327= Multiple submitters candidiasis, familial, 9
  • p.Arg14= Multiple submitters candidiasis, familial, 9
  • p.Arg295= Multiple submitters candidiasis, familial, 9
  • p.Arg401= Multiple submitters candidiasis, familial, 9
  • p.Asp461= Multiple submitters candidiasis, familial, 9
  • p.Cys270= Multiple submitters candidiasis, familial, 9
  • p.Gly218= Multiple submitters candidiasis, familial, 9
  • p.Gly604= Multiple submitters candidiasis, familial, 9
  • p.Leu356= Multiple submitters candidiasis, familial, 9
  • p.Phe105= Multiple submitters candidiasis, familial, 9
  • p.Phe662= Multiple submitters candidiasis, familial, 9
  • p.Pro323= Multiple submitters candidiasis, familial, 9
  • p.Pro333Leu Multiple submitters candidiasis, familial, 9
  • p.Pro35= Multiple submitters candidiasis, familial, 9
  • p.Ser282= Multiple submitters candidiasis, familial, 9
  • p.Ser555= Multiple submitters candidiasis, familial, 9
  • p.Ser590Gly Multiple submitters candidiasis, familial, 9
  • p.Ser674= Multiple submitters candidiasis, familial, 9
  • p.Thr64= Multiple submitters candidiasis, familial, 9
  • p.Val149Leu Multiple submitters candidiasis, familial, 9
  • p.Val283Ile Multiple submitters candidiasis, familial, 9
  • p.Val54Ala Multiple submitters candidiasis, familial, 9
  • c.105+102T>C Single submitter candidiasis, familial, 9
  • c.105+115C>T Single submitter candidiasis, familial, 9
  • c.105+129T>C Single submitter candidiasis, familial, 9
  • c.105+49T>C Single submitter candidiasis, familial, 9
  • c.105+70C>T Single submitter candidiasis, familial, 9
  • c.105+84T>C Single submitter candidiasis, familial, 9
  • c.105+93T>C Single submitter candidiasis, familial, 9
  • c.1059+16G>A Single submitter candidiasis, familial, 9
  • c.1059+17G>T Single submitter candidiasis, familial, 9
  • c.1059+19A>G Single submitter candidiasis, familial, 9
  • c.106-104T>G Single submitter candidiasis, familial, 9
  • c.106-115C>T Single submitter candidiasis, familial, 9
  • c.106-142A>G Single submitter
  • c.106-14T>G Single submitter candidiasis, familial, 9
  • c.106-4C>T Single submitter candidiasis, familial, 9
  • c.106-5C>G Single submitter candidiasis, familial, 9
  • c.106-5C>T Single submitter candidiasis, familial, 9
  • c.106-66T>G Single submitter candidiasis, familial, 9
  • c.106-83A>G Single submitter candidiasis, familial, 9
  • c.106-92G>A Single submitter candidiasis, familial, 9
  • c.106-95G>A Single submitter candidiasis, familial, 9
  • c.1060-7del Single submitter candidiasis, familial, 9
  • c.1110+9G>A Single submitter candidiasis, familial, 9
  • c.1111-15G>T Single submitter candidiasis, familial, 9
  • c.1111-17T>C Single submitter candidiasis, familial, 9
  • c.1111-18A>G Single submitter candidiasis, familial, 9
  • c.1157-10C>T Single submitter candidiasis, familial, 9
  • c.1157-11A>T Single submitter candidiasis, familial, 9
  • c.1157-14C>T Single submitter candidiasis, familial, 9
  • c.1157-16C>T Single submitter candidiasis, familial, 9
  • c.1157-17C>T Single submitter candidiasis, familial, 9
  • c.127+15T>C Single submitter candidiasis, familial, 9
  • c.127+20A>G Single submitter
  • c.127+8T>G Single submitter candidiasis, familial, 9
  • c.1278+15A>G Single submitter candidiasis, familial, 9
  • c.1278+15A>T Single submitter candidiasis, familial, 9
  • c.1278+9T>G Single submitter candidiasis, familial, 9
  • c.1279-19C>T Single submitter candidiasis, familial, 9
  • c.128-13C>A Single submitter candidiasis, familial, 9
  • c.128-16G>A Single submitter candidiasis, familial, 9
  • c.128-18C>G Single submitter candidiasis, familial, 9
  • c.128-20A>G Single submitter
  • c.128-7C>T Single submitter candidiasis, familial, 9
  • c.1338+15G>C Single submitter candidiasis, familial, 9
  • c.1338+17A>G Single submitter candidiasis, familial, 9
  • c.1338+8G>C Single submitter candidiasis, familial, 9
  • c.1339-11G>C Single submitter candidiasis, familial, 9
  • c.1339-13T>C Single submitter candidiasis, familial, 9
  • c.1339-15G>T Single submitter candidiasis, familial, 9
  • c.1387+10G>C Single submitter candidiasis, familial, 9
  • c.1387+10G>T Single submitter candidiasis, familial, 9
  • c.1387+11_1387+12insTT Single submitter candidiasis, familial, 9
  • c.1387+17C>G Single submitter candidiasis, familial, 9
  • c.1387+20C>T Single submitter candidiasis, familial, 9
  • c.1387+9T>A Single submitter candidiasis, familial, 9
  • c.1388-13C>T Single submitter candidiasis, familial, 9
  • c.1483+19C>A Single submitter candidiasis, familial, 9
  • c.1483+9T>C Single submitter candidiasis, familial, 9
  • c.1484-17C>A Single submitter candidiasis, familial, 9
  • c.1522+19dup Single submitter candidiasis, familial, 9
  • c.1522+9G>A Single submitter
  • c.1523-11T>C Single submitter candidiasis, familial, 9
  • c.1523-14G>A Single submitter candidiasis, familial, 9
  • c.1523-16_1523-15del Single submitter candidiasis, familial, 9
  • c.1523-16C>T Single submitter candidiasis, familial, 9
  • c.1523-19C>T Single submitter candidiasis, familial, 9
  • c.1523-33A>C Single submitter
  • c.1523-5G>C Single submitter candidiasis, familial, 9
  • c.1523-6C>T Single submitter candidiasis, familial, 9
  • c.1523-7C>G Single submitter candidiasis, familial, 9
  • c.280+11C>T Single submitter candidiasis, familial, 9
  • c.280+9G>C Single submitter candidiasis, familial, 9
  • c.355+12C>G Single submitter candidiasis, familial, 9
  • c.355+19G>T Single submitter candidiasis, familial, 9
  • c.355+20C>T Single submitter candidiasis, familial, 9
  • c.356-10T>C Single submitter candidiasis, familial, 9
  • c.356-15C>A Single submitter candidiasis, familial, 9
  • c.356-16dup Single submitter candidiasis, familial, 9
  • c.356-19C>G Single submitter candidiasis, familial, 9
  • c.356-19C>T Single submitter candidiasis, familial, 9
  • c.356-7C>T Single submitter candidiasis, familial, 9
  • c.466-12C>A Single submitter candidiasis, familial, 9
  • c.466-12C>T Single submitter candidiasis, familial, 9
  • c.466-13C>A Single submitter candidiasis, familial, 9
  • c.466-18T>G Single submitter candidiasis, familial, 9
  • c.577+13C>T Single submitter candidiasis, familial, 9
  • c.577+7G>A Single submitter candidiasis, familial, 9
  • c.577+9A>G Single submitter candidiasis, familial, 9
  • c.578-5C>T Single submitter candidiasis, familial, 9
  • c.622+10A>G Single submitter candidiasis, familial, 9
  • c.622+12G>A Single submitter candidiasis, familial, 9
  • c.623-4C>T Single submitter candidiasis, familial, 9
  • c.822+14C>G Single submitter candidiasis, familial, 9
  • c.822+14C>T Single submitter candidiasis, familial, 9
  • c.822+17G>A Single submitter candidiasis, familial, 9
  • c.823-15C>G Single submitter candidiasis, familial, 9
  • c.823-18C>T Single submitter candidiasis, familial, 9
  • c.877+10C>G Single submitter candidiasis, familial, 9
  • c.877+11C>A Single submitter candidiasis, familial, 9
  • c.877+11C>G Single submitter candidiasis, familial, 9
  • c.877+13G>A Single submitter candidiasis, familial, 9
  • c.877+15C>T Single submitter candidiasis, familial, 9
  • c.877+18G>A Single submitter candidiasis, familial, 9
  • c.877+18G>C Single submitter candidiasis, familial, 9
  • c.877+20G>C Single submitter
  • c.877+8G>A Single submitter candidiasis, familial, 9
  • c.878-17G>A Single submitter candidiasis, familial, 9
  • c.878-18T>C Single submitter candidiasis, familial, 9
  • c.878-19C>A Single submitter candidiasis, familial, 9
  • c.878-19C>T Single submitter
  • c.878-5T>C Single submitter candidiasis, familial, 9
  • c.878-7C>A Single submitter candidiasis, familial, 9
  • c.878-9T>C Single submitter candidiasis, familial, 9
  • p.Ala119= Single submitter candidiasis, familial, 9
  • p.Ala147= Single submitter candidiasis, familial, 9
  • p.Ala166= Single submitter candidiasis, familial, 9
  • p.Ala208= Single submitter candidiasis, familial, 9
  • p.Ala318= Single submitter candidiasis, familial, 9
  • p.Ala424= Single submitter candidiasis, familial, 9
  • p.Ala474= Single submitter candidiasis, familial, 9
  • p.Ala480= Single submitter candidiasis, familial, 9
  • p.Ala493= Single submitter candidiasis, familial, 9
  • p.Ala508= Single submitter candidiasis, familial, 9
  • p.Ala509= Single submitter candidiasis, familial, 9
  • p.Ala521= Single submitter candidiasis, familial, 9
  • p.Ala545= Single submitter candidiasis, familial, 9
  • p.Ala556= Single submitter candidiasis, familial, 9
  • p.Ala585= Single submitter candidiasis, familial, 9
  • p.Ala642= Single submitter
  • p.Ala681= Single submitter candidiasis, familial, 9
  • p.Ala91= Single submitter candidiasis, familial, 9
  • p.Arg249= Single submitter candidiasis, familial, 9
  • p.Arg331Gln Single submitter candidiasis, familial, 9
  • p.Arg407= Single submitter candidiasis, familial, 9
  • p.Arg430= Single submitter candidiasis, familial, 9
  • p.Arg498= Single submitter candidiasis, familial, 9
  • p.Arg511= Single submitter candidiasis, familial, 9
  • p.Arg567= Single submitter candidiasis, familial, 9
  • p.Arg624Gln Single submitter candidiasis, familial, 9
  • p.Arg676= Single submitter candidiasis, familial, 9
  • p.Arg706= Single submitter candidiasis, familial, 9
  • p.Arg85= Single submitter candidiasis, familial, 9
  • p.Asn186= Single submitter
  • p.Asn213= Single submitter candidiasis, familial, 9
  • p.Asn220= Single submitter candidiasis, familial, 9
  • p.Asn240= Single submitter candidiasis, familial, 9
  • p.Asn253= Single submitter candidiasis, familial, 9
  • p.Asp281= Single submitter candidiasis, familial, 9
  • p.Asp29= Single submitter candidiasis, familial, 9
  • p.Asp293= Single submitter candidiasis, familial, 9
  • p.Asp336= Single submitter candidiasis, familial, 9
  • p.Asp393= Single submitter candidiasis, familial, 9
  • p.Asp405= Single submitter candidiasis, familial, 9
  • p.Asp449= Single submitter candidiasis, familial, 9
  • p.Asp451= Single submitter candidiasis, familial, 9
  • p.Asp619= Single submitter candidiasis, familial, 9
  • p.Asp81= Single submitter
  • p.Cys137= Single submitter candidiasis, familial, 9
  • p.Cys329= Single submitter candidiasis, familial, 9
  • p.Cys417= Single submitter candidiasis, familial, 9
  • p.Cys475= Single submitter candidiasis, familial, 9
  • p.Gln258= Single submitter candidiasis, familial, 9
  • p.Gln307= Single submitter candidiasis, familial, 9
  • p.Gln437= Single submitter candidiasis, familial, 9
  • p.Gln572= Single submitter candidiasis, familial, 9
  • p.Gln594= Single submitter candidiasis, familial, 9
  • p.Gln622= Single submitter candidiasis, familial, 9
  • p.Gln689= Single submitter candidiasis, familial, 9
  • p.Glu103= Single submitter candidiasis, familial, 9
  • p.Glu141= Single submitter candidiasis, familial, 9
  • p.Glu229= Single submitter candidiasis, familial, 9
  • p.Glu682= Single submitter candidiasis, familial, 9
  • p.Glu98= Single submitter candidiasis, familial, 9
  • p.Gly106= Single submitter
  • p.Gly168= Single submitter candidiasis, familial, 9
  • p.Gly196= Single submitter candidiasis, familial, 9
  • p.Gly26= Single submitter candidiasis, familial, 9
  • p.Gly334= Single submitter candidiasis, familial, 9
  • p.Gly335= Single submitter candidiasis, familial, 9
  • p.Gly558= Single submitter candidiasis, familial, 9
  • p.Gly574= Single submitter candidiasis, familial, 9
  • p.Gly599= Single submitter candidiasis, familial, 9
  • p.Gly601= Single submitter
  • p.Gly664= Single submitter candidiasis, familial, 9
  • p.Gly707= Single submitter candidiasis, familial, 9
  • p.Gly719= Single submitter candidiasis, familial, 9
  • p.His32= Single submitter candidiasis, familial, 9
  • p.His606= Single submitter candidiasis, familial, 9
  • p.His697= Single submitter
  • p.Ile203= Single submitter candidiasis, familial, 9
  • p.Ile260= Single submitter candidiasis, familial, 9
  • p.Ile464Val Single submitter
  • p.Ile53= Single submitter candidiasis, familial, 9
  • p.Leu19= Single submitter candidiasis, familial, 9
  • p.Leu197= Single submitter candidiasis, familial, 9
  • p.Leu209= Single submitter candidiasis, familial, 9
  • p.Leu237= Single submitter candidiasis, familial, 9
  • p.Leu24= Single submitter candidiasis, familial, 9
  • p.Leu254= Single submitter
  • p.Leu278= Single submitter candidiasis, familial, 9
  • p.Leu311= Single submitter candidiasis, familial, 9
  • p.Leu315= Single submitter candidiasis, familial, 9
  • p.Leu316= Single submitter candidiasis, familial, 9
  • p.Leu322= Single submitter candidiasis, familial, 9
  • p.Leu360= Single submitter candidiasis, familial, 9
  • p.Leu367= Single submitter candidiasis, familial, 9
  • p.Leu379= Single submitter candidiasis, familial, 9
  • p.Leu435= Single submitter candidiasis, familial, 9
  • p.Leu436= Single submitter candidiasis, familial, 9
  • p.Leu439= Single submitter candidiasis, familial, 9
  • p.Leu447= Single submitter candidiasis, familial, 9
  • p.Leu452= Single submitter candidiasis, familial, 9
  • p.Leu47= Single submitter candidiasis, familial, 9
  • p.Leu477= Single submitter candidiasis, familial, 9
  • p.Leu49= Single submitter candidiasis, familial, 9
  • p.Leu497= Single submitter candidiasis, familial, 9
  • p.Leu499= Single submitter candidiasis, familial, 9
  • p.Leu517= Single submitter candidiasis, familial, 9
  • p.Leu518= Single submitter candidiasis, familial, 9
  • p.Leu529= Single submitter candidiasis, familial, 9
  • p.Leu537= Single submitter candidiasis, familial, 9
  • p.Leu548= Single submitter candidiasis, familial, 9
  • p.Leu554= Single submitter candidiasis, familial, 9
  • p.Leu571= Single submitter candidiasis, familial, 9
  • p.Leu580= Single submitter candidiasis, familial, 9
  • p.Leu61= Single submitter candidiasis, familial, 9
  • p.Leu613= Single submitter candidiasis, familial, 9
  • p.Leu655= Single submitter candidiasis, familial, 9
  • p.Leu66= Single submitter candidiasis, familial, 9
  • p.Leu692= Single submitter candidiasis, familial, 9
  • p.Leu7= Single submitter candidiasis, familial, 9
  • p.Leu70Val Single submitter candidiasis, familial, 9
  • p.Leu82= Single submitter candidiasis, familial, 9
  • p.Leu90= Single submitter candidiasis, familial, 9
  • p.Lys362= Single submitter candidiasis, familial, 9
  • p.Phe233= Single submitter candidiasis, familial, 9
  • p.Phe609= Single submitter candidiasis, familial, 9
  • p.Pro2= Single submitter candidiasis, familial, 9
  • p.Pro204= Single submitter candidiasis, familial, 9
  • p.Pro246= Single submitter candidiasis, familial, 9
  • p.Pro269= Single submitter candidiasis, familial, 9
  • p.Pro280= Single submitter candidiasis, familial, 9
  • p.Pro289= Single submitter candidiasis, familial, 9
  • p.Pro333= Single submitter candidiasis, familial, 9
  • p.Pro343= Single submitter candidiasis, familial, 9
  • p.Pro344= Single submitter candidiasis, familial, 9
  • p.Pro359= Single submitter candidiasis, familial, 9
  • p.Pro403= Single submitter candidiasis, familial, 9
  • p.Pro57= Single submitter candidiasis, familial, 9
  • p.Pro583= Single submitter candidiasis, familial, 9
  • p.Pro59= Single submitter candidiasis, familial, 9
  • p.Pro600= Single submitter candidiasis, familial, 9
  • p.Pro605= Single submitter candidiasis, familial, 9
  • p.Pro626= Single submitter candidiasis, familial, 9
  • p.Pro651= Single submitter candidiasis, familial, 9
  • p.Pro699= Single submitter candidiasis, familial, 9
  • p.Pro704= Single submitter candidiasis, familial, 9
  • p.Ser15= Single submitter candidiasis, familial, 9
  • p.Ser175= Single submitter candidiasis, familial, 9
  • p.Ser202= Single submitter candidiasis, familial, 9
  • p.Ser321= Single submitter candidiasis, familial, 9
  • p.Ser373= Single submitter candidiasis, familial, 9
  • p.Ser374= Single submitter candidiasis, familial, 9
  • p.Ser408= Single submitter candidiasis, familial, 9
  • p.Ser506= Single submitter candidiasis, familial, 9

Uncertain significance 480

Showing the top 300 by review status; the full set is in the sitemap.