IL18 — 15 ClinVar variants
All ClinVar germline IL18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
4 Benign · 4 Likely benign · 7 Uncertain significance
Full IL18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All IL18 variants
Benign 4
- c.80-5C>A Single submitter
- p.Ser35= Single submitter
- c.361-1974C>T No assertion criteria Three Vessel Coronary Disease
- c.-8-919T>C No assertion criteria Three Vessel Coronary Disease
Likely benign 4
- p.Arg63Gln Single submitter
- p.Glu164Lys Single submitter
- p.Ser133Asn Single submitter
- p.Ser72= Single submitter
Uncertain significance 7
- p.Arg167Lys Single submitter ⚠
- p.Asp36Asn Single submitter ⚠
- p.Leu110Ile Single submitter ⚠
- p.Met122Val Single submitter ⚠
- p.Met149Thr Single submitter ⚠
- p.Phe25Cys Single submitter ⚠
- p.Phe66Cys Single submitter ⚠