IL1A — 44 ClinVar variants
All ClinVar germline IL1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
4 Benign · 8 Likely benign · 32 Uncertain significance
Full IL1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL1A p.Ala238Val Uncertain significance Single submitter
- IL1A p.Ala245Asp Uncertain significance Single submitter
- IL1A p.Asn121Ser Uncertain significance Single submitter
- IL1A p.Asn141Ser Uncertain significance Single submitter
- IL1A p.Asn148Thr Uncertain significance Single submitter
- IL1A p.Asn18Lys Uncertain significance Single submitter
- IL1A p.Asn232Thr Uncertain significance Single submitter
- IL1A p.Asp103Val Uncertain significance Single submitter
- IL1A p.Asp94Val Uncertain significance Single submitter
- IL1A p.Gln265Leu Uncertain significance Single submitter
- IL1A p.Glu133Lys Uncertain significance Single submitter
- IL1A p.Gly169Ala Uncertain significance Single submitter
- IL1A p.Ile144Met Uncertain significance Single submitter
- IL1A p.Ile180Asn Uncertain significance Single submitter
- IL1A p.Ile186Leu Uncertain significance Single submitter
- IL1A p.Ile25Val Uncertain significance Single submitter
- IL1A p.Leu88Val Uncertain significance Single submitter
- IL1A p.Phe8Ile Uncertain significance Single submitter
- IL1A p.Pro115Thr Uncertain significance Single submitter
- IL1A p.Pro211Ser Uncertain significance Single submitter
- IL1A p.Ser173Ala Uncertain significance Single submitter
- IL1A p.Ser55Asn Uncertain significance Single submitter
- IL1A p.Ser89Arg Uncertain significance Single submitter
- IL1A p.Thr62Ala Uncertain significance Single submitter
- IL1A p.Tyr171Cys Uncertain significance Single submitter
- IL1A p.Val38Gly Uncertain significance Single submitter
- IL1A p.Val52Ala Uncertain significance Single submitter
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IL1A p.Ile109Val
Uncertain significance
No assertion criteria
IL1A-related disorder
Predictors split 3
The independent predictors disagree with each other — read with care.
All IL1A variants
Benign 4
- p.Asp138Asn Multiple submitters
- p.Ile92= Multiple submitters
- c.*925_*928dup Single submitter
- p.Ala114Ser No assertion criteria IL1A-related disorder
Likely benign 8
- p.Thr153= Multiple submitters
- p.Asn125Asp Single submitter
- p.Glu133Gln Single submitter
- p.His37Asp Single submitter
- p.Thr153Met Single submitter
- c.*10C>T No assertion criteria IL1A-related disorder
- p.Gln90Lys No assertion criteria IL1A-related disorder
- p.Met48Val No assertion criteria IL1A-related disorder
Uncertain significance 32
- p.Ala238Val Single submitter ⚠
- p.Ala245Asp Single submitter ⚠
- p.Asn121Ser Single submitter ⚠
- p.Asn141Ser Single submitter ⚠
- p.Asn148Thr Single submitter ⚠
- p.Asn18Lys Single submitter ⚠
- p.Asn232Thr Single submitter ⚠
- p.Asp103Val Single submitter ⚠
- p.Asp10His Single submitter ⚠
- p.Asp94Val Single submitter ⚠
- p.Gln142His Single submitter ⚠
- p.Gln265Leu Single submitter ⚠
- p.Glu133Lys Single submitter ⚠
- p.Gly169Ala Single submitter ⚠
- p.Gly78Glu Single submitter
- p.Ile144Met Single submitter ⚠
- p.Ile180Asn Single submitter ⚠
- p.Ile186Leu Single submitter ⚠
- p.Ile25Val Single submitter ⚠
- p.Leu88Val Single submitter ⚠
- p.Phe8Ile Single submitter ⚠
- p.Pro115Thr Single submitter ⚠
- p.Pro211Ser Single submitter ⚠
- p.Ser173Ala Single submitter ⚠
- p.Ser55Asn Single submitter ⚠
- p.Ser89Arg Single submitter ⚠
- p.Thr189Ile Single submitter ⚠
- p.Thr62Ala Single submitter ⚠
- p.Tyr171Cys Single submitter ⚠
- p.Val38Gly Single submitter ⚠
- p.Val52Ala Single submitter ⚠
- p.Ile109Val No assertion criteria IL1A-related disorder ⚠