IL33 — 51 ClinVar variants
All ClinVar germline IL33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
6 Benign · 4 Likely benign · 41 Uncertain significance
Full IL33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL33 p.Ala137Thr Uncertain significance Single submitter
- IL33 p.Ala15Thr Uncertain significance Single submitter
- IL33 p.Ala216Thr Uncertain significance Single submitter
- IL33 p.Ala57Thr Uncertain significance Single submitter
- IL33 p.Asp131Asn Uncertain significance Single submitter
- IL33 p.Asp149Gly Uncertain significance Single submitter
- IL33 p.Asp153His Uncertain significance Single submitter
- IL33 p.Asp157Glu Uncertain significance Single submitter
- IL33 p.Asp191His Uncertain significance Single submitter
- IL33 p.Asp253His Uncertain significance Single submitter
- IL33 p.Cys259Arg Uncertain significance Single submitter
- IL33 p.Cys26Phe Uncertain significance Single submitter
- IL33 p.Glu204Lys Uncertain significance Single submitter
- IL33 p.Glu256Ala Uncertain significance Single submitter
- IL33 p.Gly100Glu Uncertain significance Single submitter
- IL33 p.Gly179Ala Uncertain significance Single submitter
- IL33 p.His246Leu Uncertain significance Single submitter
- IL33 p.Ile240Thr Uncertain significance Single submitter
- IL33 p.Leu160Ile Uncertain significance Single submitter
- IL33 p.Leu80Pro Uncertain significance Single submitter
- IL33 p.Lys158Thr Uncertain significance Single submitter
- IL33 p.Lys16Arg Uncertain significance Single submitter
- IL33 p.Lys28Asn Uncertain significance Single submitter
- IL33 p.Lys4Glu Uncertain significance Single submitter
- IL33 p.Lys4Thr Uncertain significance Single submitter
- IL33 p.Lys55Arg Uncertain significance Single submitter
- IL33 p.Met223Ile Uncertain significance Single submitter
- IL33 p.Phe230Ser Uncertain significance Single submitter
- IL33 p.Phe60Ser Uncertain significance Single submitter
- IL33 p.Ser111Thr Uncertain significance Single submitter
- IL33 p.Ser187Asn Uncertain significance Single submitter
- IL33 p.Ser22Asn Uncertain significance Single submitter
- IL33 p.Ser89Phe Uncertain significance Single submitter
- IL33 p.Ser99Ala Uncertain significance Single submitter
- IL33 p.Ser99Leu Uncertain significance Single submitter
- IL33 p.Tyr146Cys Uncertain significance Single submitter
- IL33 p.Val252Ala Uncertain significance Single submitter
-
IL33 p.Val238Met
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 2
The independent predictors disagree with each other — read with care.
All IL33 variants
Benign 6
- p.His201Gln Multiple submitters
- p.Ile263Met Multiple submitters
- c.91+1165C>T Single submitter
- p.Asp153Tyr Single submitter
- p.Gly50= Single submitter
- p.Val91= Single submitter
Likely benign 4
- c.613-1G>C Single submitter
- p.His195Gln Single submitter
- p.Ile119Val Single submitter
- p.Leu82Phe Single submitter
Uncertain significance 41
- p.Ala137Thr Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Arg48Cys Single submitter
- p.Asp131Asn Single submitter ⚠
- p.Asp149Gly Single submitter ⚠
- p.Asp153His Single submitter ⚠
- p.Asp157Glu Single submitter ⚠
- p.Asp191His Single submitter ⚠
- p.Asp253His Single submitter ⚠
- p.Cys259Arg Single submitter ⚠
- p.Cys26Phe Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu256Ala Single submitter ⚠
- p.Gly100Glu Single submitter ⚠
- p.Gly179Ala Single submitter ⚠
- p.His246Leu Single submitter ⚠
- p.Ile240Thr Single submitter ⚠
- p.Leu160Ile Single submitter ⚠
- p.Leu80Pro Single submitter ⚠
- p.Lys158Thr Single submitter ⚠
- p.Lys16Arg Single submitter ⚠
- p.Lys28Asn Single submitter ⚠
- p.Lys4Glu Single submitter ⚠
- p.Lys4Thr Single submitter ⚠
- p.Lys55Arg Single submitter ⚠
- p.Met223Ile Single submitter ⚠
- p.Phe230Ser Single submitter ⚠
- p.Phe239Ser Single submitter ⚠
- p.Phe60Ser Single submitter ⚠
- p.Ser111Thr Single submitter ⚠
- p.Ser125Pro Single submitter ⚠
- p.Ser187Asn Single submitter ⚠
- p.Ser22Asn Single submitter ⚠
- p.Ser89Phe Single submitter ⚠
- p.Ser99Ala Single submitter ⚠
- p.Ser99Leu Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Val252Ala Single submitter ⚠
- p.Val238Met No assertion criteria prostate cancer ⚠