IL36G — 28 ClinVar variants
All ClinVar germline IL36G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 27 Uncertain significance
Full IL36G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL36G p.Arg121Cys Uncertain significance Single submitter
- IL36G p.Arg13Thr Uncertain significance Single submitter
- IL36G p.Arg47Gln Uncertain significance Single submitter
- IL36G p.Asn31Thr Uncertain significance Single submitter
- IL36G p.Asp73Asn Uncertain significance Single submitter
- IL36G p.Asp7Gly Uncertain significance Single submitter
- IL36G p.Gln94Glu Uncertain significance Single submitter
- IL36G p.Glu68Lys Uncertain significance Single submitter
- IL36G p.Ile104Met Uncertain significance Single submitter
- IL36G p.Ile140Thr Uncertain significance Single submitter
- IL36G p.Leu155Ile Uncertain significance Single submitter
- IL36G p.Pro46Gln Uncertain significance Single submitter
- IL36G p.Thr60Ala Uncertain significance Single submitter
- IL36G p.Tyr159His Uncertain significance Single submitter
- IL36G p.Tyr87His Uncertain significance Single submitter
- IL36G p.Val114Met Uncertain significance Single submitter
- IL36G p.Val15Ala Uncertain significance Single submitter
- IL36G p.Val15Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- IL36G p.Asp146Tyr Uncertain significance Single submitter
- IL36G p.Cys61Phe Uncertain significance Single submitter
- IL36G p.Gly78Glu Uncertain significance Single submitter
- IL36G p.Leu77Val Uncertain significance Single submitter
- IL36G p.Lys62Glu Uncertain significance Single submitter
- IL36G p.Pro136Leu Uncertain significance Single submitter
- IL36G p.Thr152Asn Uncertain significance Single submitter
- IL36G p.Val91Phe Uncertain significance Single submitter
All IL36G variants
Likely benign 1
- p.Val15Ile Single submitter
Uncertain significance 27
- p.Arg121Cys Single submitter ⚠
- p.Arg13Thr Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Asn31Thr Single submitter ⚠
- p.Asp146Tyr Single submitter ⚠
- p.Asp73Asn Single submitter ⚠
- p.Asp7Gly Single submitter ⚠
- p.Cys61Phe Single submitter ⚠
- p.Cys85Phe Single submitter
- p.Gln94Glu Single submitter ⚠
- p.Glu68Lys Single submitter ⚠
- p.Gly78Glu Single submitter ⚠
- p.Ile104Met Single submitter ⚠
- p.Ile140Thr Single submitter ⚠
- p.Leu155Ile Single submitter ⚠
- p.Leu77Val Single submitter ⚠
- p.Lys62Glu Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro46Gln Single submitter ⚠
- p.Thr152Asn Single submitter ⚠
- p.Thr60Ala Single submitter ⚠
- p.Tyr159His Single submitter ⚠
- p.Tyr87His Single submitter ⚠
- p.Val114Met Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val15Phe Single submitter ⚠
- p.Val91Phe Single submitter ⚠