IL36RN — 207 ClinVar variants
All ClinVar germline IL36RN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
8 Pathogenic · 1 Pathogenic/Likely pathogenic · 4 Likely pathogenic · 22 Conflicting · 17 Benign · 2 Benign/Likely benign · 56 Likely benign · 97 Uncertain significance
Full IL36RN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 5
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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IL36RN p.Gly141Ser
Conflicting
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ile146Val
Conflicting
Single submitter
generalized pustular psoriasis
-
IL36RN p.Pro76Leu
Conflicting
Single submitter
generalized pustular psoriasis
-
IL36RN p.Pro82Leu
Conflicting
Single submitter
generalized pustular psoriasis
-
IL36RN p.Val57Ile
Conflicting
Single submitter
autoinflammatory syndrome
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
IL36RN p.Arg103Gln
Uncertain significance
Multiple submitters
autoinflammatory syndrome
-
IL36RN p.Arg10Gln
Uncertain significance
Multiple submitters
autoinflammatory syndrome
-
IL36RN p.Glu112Lys
Uncertain significance
Multiple submitters
generalized pustular psoriasis
-
IL36RN p.Gly63Val
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
IL36RN p.Lys35Arg
Uncertain significance
Multiple submitters
generalized pustular psoriasis
-
IL36RN p.Lys93Glu
Uncertain significance
Multiple submitters
generalized pustular psoriasis
-
IL36RN p.Met105Val
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
IL36RN p.Thr77Ile
Uncertain significance
Multiple submitters
generalized pustular psoriasis
- IL36RN p.Ala15Ser Uncertain significance Single submitter
-
IL36RN p.Ala33Thr
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ala6Val
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ala92Val
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Arg102Gln
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Asn47Ile
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Cys67Phe
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Cys70Arg
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Gln129Arg
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Gln153Arg
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Glu41Asp
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Glu87Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
IL36RN p.Gly140Cys
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Gly140Ser
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Gly141Asp
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Gly30Glu
Uncertain significance
Single submitter
Inborn genetic diseases
- IL36RN p.Gly34Ala Uncertain significance Single submitter
-
IL36RN p.Gly60Val
Uncertain significance
Single submitter
psoriasis 14, pustular
-
IL36RN p.Gly64Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
IL36RN p.Ile85Val
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Leu107Phe
Uncertain significance
Single submitter
Inborn genetic diseases
-
IL36RN p.Leu31Met
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Pro145Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
IL36RN p.Ser14Ala
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ser55Cys
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ser55Phe
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ser65Asn
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Ser97Arg
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Thr108Ser
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Tyr101Phe
Uncertain significance
Single submitter
generalized pustular psoriasis
- IL36RN p.Val2Phe Uncertain significance Single submitter
-
IL36RN p.Val44Met
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Val72Ala
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Val72Gly
Uncertain significance
Single submitter
Inborn genetic diseases
Predictors split 12
The independent predictors disagree with each other — read with care.
-
IL36RN p.Phe151Ile
Uncertain significance
Multiple submitters
generalized pustular psoriasis
-
IL36RN p.Pro117Ala
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
IL36RN p.Pro46Ser
Uncertain significance
Multiple submitters
generalized pustular psoriasis
-
IL36RN p.Val44Leu
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
IL36RN p.Val45Ala
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
IL36RN p.Val83Glu
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
IL36RN p.Arg103Trp
Conflicting
Single submitter
generalized pustular psoriasis
-
IL36RN p.Arg48Trp
Conflicting
Single submitter
IL36RN-related disorders
-
IL36RN p.Asn47Asp
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Gly39Cys
Uncertain significance
Single submitter
psoriasis 14, pustular
-
IL36RN p.Pro117Gln
Uncertain significance
Single submitter
generalized pustular psoriasis
-
IL36RN p.Pro117Leu
Uncertain significance
Single submitter
generalized pustular psoriasis
All IL36RN variants
Pathogenic 8
- p.Leu27Pro Multiple submitters IL36RN-related disorders
- p.Ala6fs Single submitter generalized pustular psoriasis
- p.Ala92fs Single submitter generalized pustular psoriasis
- p.Gln62Ter Single submitter generalized pustular psoriasis
- p.Gly141fs Single submitter generalized pustular psoriasis
- p.Ser14Ter Single submitter generalized pustular psoriasis
- p.Ser69fs Single submitter psoriasis 14, pustular
- p.Thr123Arg No assertion criteria psoriasis 14, pustular
Pathogenic/Likely pathogenic 1
- c.115+6T>C Multiple submitters autoinflammatory syndrome
Likely pathogenic 4
- c.29+1G>A Single submitter generalized pustular psoriasis
- c.30-1G>T Single submitter generalized pustular psoriasis
- c.30-2A>G Single submitter generalized pustular psoriasis
- p.Ser113Ter Single submitter psoriasis 14, pustular
Conflicting classifications of pathogenicity 22
- c.244-6C>T Single submitter autoinflammatory syndrome
- c.*222T>C Single submitter psoriasis 14, pustular
- c.*276A>G Single submitter psoriasis 14, pustular
- c.*326C>A Single submitter psoriasis 14, pustular
- c.*401A>T Single submitter psoriasis 14, pustular
- c.*418A>G Single submitter psoriasis 14, pustular
- c.*560C>G Single submitter psoriasis 14, pustular
- p.Ala127= Single submitter autoinflammatory syndrome
- p.Arg103Trp Single submitter generalized pustular psoriasis ⚠
- p.Arg10Ter Single submitter IL36RN-related disorders
- p.Arg48Trp Single submitter IL36RN-related disorders ⚠
- p.Gly141Ser Single submitter generalized pustular psoriasis ⚠
- p.Ile146Val Single submitter generalized pustular psoriasis ⚠
- p.Leu121= Single submitter autoinflammatory syndrome
- p.Phe111= Single submitter generalized pustular psoriasis
- p.Pro117= Single submitter generalized pustular psoriasis
- p.Pro76Leu Single submitter generalized pustular psoriasis ⚠
- p.Pro82Leu Single submitter generalized pustular psoriasis ⚠
- p.Ser113Leu Single submitter IL36RN-related disorders
- p.Thr123Met Single submitter psoriasis 14, pustular
- p.Val2= Single submitter generalized pustular psoriasis
- p.Val57Ile Single submitter autoinflammatory syndrome ⚠
Benign 17
- c.*1082C>A Multiple submitters generalized pustular psoriasis
- c.*1399T>C Multiple submitters generalized pustular psoriasis
- c.*1633C>T Multiple submitters generalized pustular psoriasis
- c.*1634A>G Multiple submitters generalized pustular psoriasis
- c.*1881G>T Multiple submitters generalized pustular psoriasis
- c.*1914C>T Multiple submitters generalized pustular psoriasis
- c.*1987G>A Multiple submitters generalized pustular psoriasis
- c.*478T>C Multiple submitters generalized pustular psoriasis
- c.*828G>A Multiple submitters generalized pustular psoriasis
- c.*863C>T Multiple submitters generalized pustular psoriasis
- c.*946T>C Multiple submitters generalized pustular psoriasis
- c.115+118G>A Single submitter
- c.116-87T>C Single submitter
- c.29+137C>T Single submitter
- c.-27-47A>C Single submitter
- c.-27-49C>G Single submitter
- c.*935G>C Single submitter generalized pustular psoriasis
Benign/Likely benign 2
- p.Asn47Ser Multiple submitters autoinflammatory syndrome
- p.Thr123= Multiple submitters autoinflammatory syndrome
Likely benign 56
- c.115+15A>G Multiple submitters generalized pustular psoriasis
- c.*1902T>C Multiple submitters generalized pustular psoriasis
- c.*308T>G Multiple submitters generalized pustular psoriasis
- p.Gln25= Multiple submitters generalized pustular psoriasis
- p.Leu80= Multiple submitters generalized pustular psoriasis
- p.Phe149= Multiple submitters generalized pustular psoriasis
- p.Ser113= Multiple submitters generalized pustular psoriasis
- c.115+14C>T Single submitter generalized pustular psoriasis
- c.115+7G>A Single submitter generalized pustular psoriasis
- c.115+8A>T Single submitter
- c.115+9T>C Single submitter generalized pustular psoriasis
- c.116-11C>T Single submitter generalized pustular psoriasis
- c.116-5C>G Single submitter generalized pustular psoriasis
- c.116-6C>T Single submitter generalized pustular psoriasis
- c.243+16T>C Single submitter generalized pustular psoriasis
- c.243+20C>T Single submitter generalized pustular psoriasis
- c.244-10C>A Single submitter generalized pustular psoriasis
- c.244-13C>A Single submitter generalized pustular psoriasis
- c.244-13C>T Single submitter generalized pustular psoriasis
- c.244-15C>T Single submitter generalized pustular psoriasis
- c.244-17C>T Single submitter generalized pustular psoriasis
- c.244-9_244-6del Single submitter generalized pustular psoriasis
- c.29+15C>A Single submitter generalized pustular psoriasis
- c.29+15C>G Single submitter generalized pustular psoriasis
- c.29+15C>T Single submitter generalized pustular psoriasis
- c.29+7G>A Single submitter generalized pustular psoriasis
- c.30-12C>T Single submitter generalized pustular psoriasis
- c.30-13C>T Single submitter generalized pustular psoriasis
- c.30-18C>A Single submitter generalized pustular psoriasis
- c.*1660G>A Single submitter generalized pustular psoriasis
- c.*1763G>A Single submitter generalized pustular psoriasis
- c.*281G>A Single submitter generalized pustular psoriasis
- p.Ala6= Single submitter generalized pustular psoriasis
- p.Arg102= Single submitter generalized pustular psoriasis
- p.Arg103= Single submitter generalized pustular psoriasis
- p.Cys122= Single submitter generalized pustular psoriasis
- p.Cys70= Single submitter generalized pustular psoriasis
- p.Gln129= Single submitter generalized pustular psoriasis
- p.Glu94= Single submitter generalized pustular psoriasis
- p.Gly106= Single submitter generalized pustular psoriasis
- p.Gly30= Single submitter generalized pustular psoriasis
- p.Gly34= Single submitter generalized pustular psoriasis
- p.Leu50= Single submitter generalized pustular psoriasis
- p.Lys96= Single submitter generalized pustular psoriasis
- p.Pro125= Single submitter generalized pustular psoriasis
- p.Pro137= Single submitter generalized pustular psoriasis
- p.Pro145= Single submitter generalized pustular psoriasis
- p.Pro56= Single submitter generalized pustular psoriasis
- p.Pro76= Single submitter generalized pustular psoriasis
- p.Ser14= Single submitter generalized pustular psoriasis
- p.Ser55= Single submitter generalized pustular psoriasis
- p.Ser97= Single submitter generalized pustular psoriasis
- p.Thr147= Single submitter generalized pustular psoriasis
- p.Thr79= Single submitter generalized pustular psoriasis
- p.Tyr116= Single submitter generalized pustular psoriasis
- p.Val124= Single submitter generalized pustular psoriasis
Uncertain significance 97
- c.115+5G>A Multiple submitters autoinflammatory syndrome
- c.244-5G>A Multiple submitters autoinflammatory syndrome
- c.*401A>C Multiple submitters generalized pustular psoriasis
- p.Arg102Trp Multiple submitters psoriasis 14, pustular
- p.Arg103Gln Multiple submitters autoinflammatory syndrome ⚠
- p.Arg10Gln Multiple submitters autoinflammatory syndrome ⚠
- p.Glu112Lys Multiple submitters generalized pustular psoriasis ⚠
- p.Gly106Ala Multiple submitters autoinflammatory syndrome
- p.Gly63Val Multiple submitters Inborn genetic diseases ⚠
- p.Leu133fs Multiple submitters generalized pustular psoriasis
- p.Lys35Arg Multiple submitters generalized pustular psoriasis ⚠
- p.Lys93Glu Multiple submitters generalized pustular psoriasis ⚠
- p.Met105Val Multiple submitters Inborn genetic diseases ⚠
- p.Phe151Ile Multiple submitters generalized pustular psoriasis ⚠
- p.Pro117Ala Multiple submitters Inborn genetic diseases ⚠
- p.Pro46Ser Multiple submitters generalized pustular psoriasis ⚠
- p.Thr77Ile Multiple submitters generalized pustular psoriasis ⚠
- p.Tyr89Cys Multiple submitters generalized pustular psoriasis
- p.Val44Leu Multiple submitters Inborn genetic diseases ⚠
- p.Val45Ala Multiple submitters Inborn genetic diseases ⚠
- p.Val83Glu Multiple submitters Inborn genetic diseases ⚠
- c.115+4G>A Single submitter generalized pustular psoriasis
- c.244-9T>A Single submitter generalized pustular psoriasis
- c.29+3G>A Single submitter autoinflammatory syndrome
- c.29+5G>A Single submitter generalized pustular psoriasis
- c.29+6T>C Single submitter generalized pustular psoriasis
- c.30-14T>A Single submitter generalized pustular psoriasis
- c.-27-299G>C Single submitter generalized pustular psoriasis
- c.-28+1G>A Single submitter psoriasis 14, pustular
- c.-47G>A Single submitter generalized pustular psoriasis
- c.*1051T>C Single submitter generalized pustular psoriasis
- c.*106G>A Single submitter generalized pustular psoriasis
- c.*1244A>G Single submitter generalized pustular psoriasis
- c.*1258C>A Single submitter generalized pustular psoriasis
- c.*1405G>T Single submitter generalized pustular psoriasis
- c.*1585A>G Single submitter generalized pustular psoriasis
- c.*15dup Single submitter autoinflammatory syndrome
- c.*1641C>G Single submitter generalized pustular psoriasis
- c.*1698G>A Single submitter generalized pustular psoriasis
- c.*1844A>G Single submitter generalized pustular psoriasis
- c.*1849T>A Single submitter generalized pustular psoriasis
- c.*1866T>C Single submitter generalized pustular psoriasis
- c.*1891G>A Single submitter generalized pustular psoriasis
- c.*1942C>G Single submitter generalized pustular psoriasis
- c.*1995T>C Single submitter generalized pustular psoriasis
- c.*298G>A Single submitter generalized pustular psoriasis
- c.*426G>T Single submitter generalized pustular psoriasis
- c.*581C>G Single submitter generalized pustular psoriasis
- c.*594T>C Single submitter generalized pustular psoriasis
- c.*6C>T Single submitter generalized pustular psoriasis
- c.*720G>T Single submitter generalized pustular psoriasis
- c.*857A>G Single submitter generalized pustular psoriasis
- c.*866G>A Single submitter generalized pustular psoriasis
- c.*883T>C Single submitter generalized pustular psoriasis
- p.Ala15Ser Single submitter ⚠
- p.Ala33Thr Single submitter generalized pustular psoriasis ⚠
- p.Ala6Val Single submitter generalized pustular psoriasis ⚠
- p.Ala92Val Single submitter generalized pustular psoriasis ⚠
- p.Arg102Gln Single submitter generalized pustular psoriasis ⚠
- p.Arg48= Single submitter generalized pustular psoriasis
- p.Arg48Pro Single submitter Inborn genetic diseases
- p.Asn47Asp Single submitter generalized pustular psoriasis ⚠
- p.Asn47Ile Single submitter generalized pustular psoriasis ⚠
- p.Cys67Phe Single submitter generalized pustular psoriasis ⚠
- p.Cys70Arg Single submitter generalized pustular psoriasis ⚠
- p.Gln129Arg Single submitter generalized pustular psoriasis ⚠
- p.Gln153Arg Single submitter generalized pustular psoriasis ⚠
- p.Glu41Asp Single submitter generalized pustular psoriasis ⚠
- p.Glu87Lys Single submitter Inborn genetic diseases ⚠
- p.Gly140Cys Single submitter generalized pustular psoriasis ⚠
- p.Gly140Ser Single submitter generalized pustular psoriasis ⚠
- p.Gly141Asp Single submitter generalized pustular psoriasis ⚠
- p.Gly30Glu Single submitter Inborn genetic diseases ⚠
- p.Gly34Ala Single submitter ⚠
- p.Gly39Cys Single submitter psoriasis 14, pustular ⚠
- p.Gly60Val Single submitter psoriasis 14, pustular ⚠
- p.Gly64Arg Single submitter Inborn genetic diseases ⚠
- p.Ile85Val Single submitter generalized pustular psoriasis ⚠
- p.Leu107Phe Single submitter Inborn genetic diseases ⚠
- p.Leu31Met Single submitter generalized pustular psoriasis ⚠
- p.Leu3Pro Single submitter generalized pustular psoriasis
- p.Pro117Gln Single submitter generalized pustular psoriasis ⚠
- p.Pro117Leu Single submitter generalized pustular psoriasis ⚠
- p.Pro145Leu Single submitter Inborn genetic diseases ⚠
- p.Ser110fs Single submitter generalized pustular psoriasis
- p.Ser113fs Single submitter generalized pustular psoriasis
- p.Ser14Ala Single submitter generalized pustular psoriasis ⚠
- p.Ser55Cys Single submitter generalized pustular psoriasis ⚠
- p.Ser55Phe Single submitter generalized pustular psoriasis ⚠
- p.Ser65Asn Single submitter generalized pustular psoriasis ⚠
- p.Ser97Arg Single submitter generalized pustular psoriasis ⚠
- p.Thr108Ser Single submitter generalized pustular psoriasis ⚠
- p.Tyr101Phe Single submitter generalized pustular psoriasis ⚠
- p.Val2Phe Single submitter ⚠
- p.Val44Met Single submitter generalized pustular psoriasis ⚠
- p.Val72Ala Single submitter generalized pustular psoriasis ⚠
- p.Val72Gly Single submitter Inborn genetic diseases ⚠