IL4 — 17 ClinVar variants
All ClinVar germline IL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
1 Benign · 16 Uncertain significance
Full IL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL4 p.Arg71Lys Uncertain significance Single submitter
- IL4 p.Arg88His Uncertain significance Single submitter
- IL4 p.Arg99Lys Uncertain significance Single submitter
- IL4 p.Asp111Asn Uncertain significance Single submitter
- IL4 p.Glu146Gln Uncertain significance Single submitter
- IL4 p.His82Gln Uncertain significance Single submitter
- IL4 p.Leu117Val Uncertain significance Single submitter
- IL4 p.Leu11Val Uncertain significance Single submitter
- IL4 p.Lys101Gln Uncertain significance Single submitter
- IL4 p.Met144Thr Uncertain significance Single submitter
- IL4 p.Phe97Ser Uncertain significance Single submitter
- IL4 p.Ser131Arg Uncertain significance Single submitter
- IL4 p.Thr142Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All IL4 variants
Benign 1
- p.Asp111= Multiple submitters
Uncertain significance 16
- p.Ala73Val Single submitter ⚠
- p.Arg71Lys Single submitter ⚠
- p.Arg88His Single submitter ⚠
- p.Arg99Lys Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Cys151Ser Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.His82Gln Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Leu11Val Single submitter ⚠
- p.Lys101Gln Single submitter ⚠
- p.Lys108Thr Single submitter ⚠
- p.Met144Thr Single submitter ⚠
- p.Phe97Ser Single submitter ⚠
- p.Ser131Arg Single submitter ⚠
- p.Thr142Met Single submitter ⚠