IL4I1 — 76 ClinVar variants
All ClinVar germline IL4I1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Likely benign · 73 Uncertain significance
Full IL4I1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL4I1 p.Ala392Val Uncertain significance Single submitter
- IL4I1 p.Ala396Thr Uncertain significance Single submitter
- IL4I1 p.Ala415Gly Uncertain significance Single submitter
- IL4I1 p.Ala419Val Uncertain significance Single submitter
- IL4I1 p.Ala5Val Uncertain significance Single submitter
- IL4I1 p.Ala67Asp Uncertain significance Single submitter
- IL4I1 p.Ala70Val Uncertain significance Single submitter
- IL4I1 p.Arg116Cys Uncertain significance Single submitter
- IL4I1 p.Arg256Gly Uncertain significance Single submitter
- IL4I1 p.Arg261Leu Uncertain significance Single submitter
- IL4I1 p.Arg28Cys Uncertain significance Single submitter
- IL4I1 p.Arg365Leu Uncertain significance Single submitter
- IL4I1 p.Arg417Ser Uncertain significance Single submitter
- IL4I1 p.Arg55Gln Uncertain significance Single submitter
- IL4I1 p.Arg564Ser Uncertain significance Single submitter
- IL4I1 p.Arg97Cys Uncertain significance Single submitter
- IL4I1 p.Asn188Ser Uncertain significance Single submitter
- IL4I1 p.Asn54Ser Uncertain significance Single submitter
- IL4I1 p.Asp513Asn Uncertain significance Single submitter
- IL4I1 p.Gln173Glu Uncertain significance Single submitter
- IL4I1 p.Gln227His Uncertain significance Single submitter
- IL4I1 p.Gln60Arg Uncertain significance Single submitter
- IL4I1 p.Glu180Gln Uncertain significance Single submitter
- IL4I1 p.Glu213Lys Uncertain significance Single submitter
- IL4I1 p.Glu218Lys Uncertain significance Single submitter
- IL4I1 p.Glu27Gln Uncertain significance Single submitter
- IL4I1 p.Glu370Lys Uncertain significance Single submitter
- IL4I1 p.Glu413Lys Uncertain significance Single submitter
- IL4I1 p.Glu465Lys Uncertain significance Single submitter
- IL4I1 p.Glu481Gly Uncertain significance Single submitter
- IL4I1 p.Glu545Gln Uncertain significance Single submitter
- IL4I1 p.Gly293Arg Uncertain significance Single submitter
- IL4I1 p.Gly371Asp Uncertain significance Single submitter
- IL4I1 p.Gly509Arg Uncertain significance Single submitter
- IL4I1 p.Gly528Glu Uncertain significance Single submitter
- IL4I1 p.Leu187Phe Uncertain significance Single submitter
- IL4I1 p.Leu187Val Uncertain significance Single submitter
- IL4I1 p.Leu228Pro Uncertain significance Single submitter
- IL4I1 p.Leu229Pro Uncertain significance Single submitter
- IL4I1 p.Leu555Phe Uncertain significance Single submitter
- IL4I1 p.Lys192Asn Uncertain significance Single submitter
- IL4I1 p.Lys195Gln Uncertain significance Single submitter
- IL4I1 p.Lys25Asn Uncertain significance Single submitter
- IL4I1 p.Met117Ile Uncertain significance Single submitter
- IL4I1 p.Pro510His Uncertain significance Single submitter
- IL4I1 p.Pro549Ser Uncertain significance Single submitter
- IL4I1 p.Ser17Arg Uncertain significance Single submitter
- IL4I1 p.Ser276Leu Uncertain significance Single submitter
- IL4I1 p.Ser450Asn Uncertain significance Single submitter
- IL4I1 p.Ser538Ala Uncertain significance Single submitter
- IL4I1 p.Thr563Arg Uncertain significance Single submitter
- IL4I1 p.Trp462Cys Uncertain significance Single submitter
- IL4I1 p.Tyr157Cys Uncertain significance Single submitter
- IL4I1 p.Tyr168Phe Uncertain significance Single submitter
- IL4I1 p.Val12Ile Uncertain significance Single submitter
- IL4I1 p.Val455Ala Uncertain significance Single submitter
- IL4I1 p.Val48Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- IL4I1 p.Arg102Trp Uncertain significance Single submitter
- IL4I1 p.Arg171Cys Uncertain significance Single submitter
- IL4I1 p.Arg271Pro Uncertain significance Single submitter
- IL4I1 p.Asp80Asn Uncertain significance Single submitter
- IL4I1 p.Gly219Ala Uncertain significance Single submitter
- IL4I1 p.Gly437Arg Uncertain significance Single submitter
- IL4I1 p.Pro362Leu Uncertain significance Single submitter
- IL4I1 p.Pro472Leu Uncertain significance Single submitter
- IL4I1 p.Trp108Arg Uncertain significance Single submitter
- IL4I1 p.Val152Gly Uncertain significance Single submitter
All IL4I1 variants
Likely benign 3
- p.Arg28His Single submitter
- p.Lys503Arg Single submitter
- p.Pro306Arg Single submitter
Uncertain significance 73
- p.Ala392Val Single submitter ⚠
- p.Ala396Thr Single submitter ⚠
- p.Ala415Gly Single submitter ⚠
- p.Ala419Val Single submitter ⚠
- p.Ala497Thr Single submitter
- p.Ala5Val Single submitter ⚠
- p.Ala67Asp Single submitter ⚠
- p.Ala70Val Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg256Gly Single submitter ⚠
- p.Arg261Leu Single submitter ⚠
- p.Arg271Pro Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Arg365Leu Single submitter ⚠
- p.Arg417Ser Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg564Ser Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Asn188Ser Single submitter ⚠
- p.Asn54Ser Single submitter ⚠
- p.Asp513Asn Single submitter ⚠
- p.Asp80Asn Single submitter ⚠
- p.Gln173Glu Single submitter ⚠
- p.Gln227His Single submitter ⚠
- p.Gln24His Single submitter
- p.Gln60Arg Single submitter ⚠
- p.Glu180Gln Single submitter ⚠
- p.Glu213Lys Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Glu27Gln Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu413Lys Single submitter ⚠
- p.Glu465Lys Single submitter ⚠
- p.Glu481Gly Single submitter ⚠
- p.Glu545Gln Single submitter ⚠
- p.Gly219Ala Single submitter ⚠
- p.Gly293Arg Single submitter ⚠
- p.Gly371Asp Single submitter ⚠
- p.Gly409Val Single submitter
- p.Gly437Arg Single submitter ⚠
- p.Gly509Arg Single submitter ⚠
- p.Gly528Glu Single submitter ⚠
- p.Leu124Phe Single submitter
- p.Leu187Phe Single submitter ⚠
- p.Leu187Val Single submitter ⚠
- p.Leu228Pro Single submitter ⚠
- p.Leu229Pro Single submitter ⚠
- p.Leu555Phe Single submitter ⚠
- p.Lys192Asn Single submitter ⚠
- p.Lys195Gln Single submitter ⚠
- p.Lys25Asn Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Met15Arg Single submitter
- p.Pro362Leu Single submitter ⚠
- p.Pro472Leu Single submitter ⚠
- p.Pro510His Single submitter ⚠
- p.Pro549Ser Single submitter ⚠
- p.Ser17Arg Single submitter ⚠
- p.Ser276Leu Single submitter ⚠
- p.Ser333Pro Single submitter
- p.Ser450Asn Single submitter ⚠
- p.Ser538Ala Single submitter ⚠
- p.Thr563Arg Single submitter ⚠
- p.Trp108Arg Single submitter ⚠
- p.Trp462Cys Single submitter ⚠
- p.Tyr157Cys Single submitter ⚠
- p.Tyr168Phe Single submitter ⚠
- p.Val12Ile Single submitter ⚠
- p.Val152Gly Single submitter ⚠
- p.Val455Ala Single submitter ⚠
- p.Val48Met Single submitter ⚠