IL6 — 20 ClinVar variants
All ClinVar germline IL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
4 Benign · 4 Likely benign · 12 Uncertain significance
Full IL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL6 p.Ala40Asp Uncertain significance Single submitter
- IL6 p.Asn183Lys Uncertain significance Single submitter
- IL6 p.Asn73Ser Uncertain significance Single submitter
- IL6 p.Lys178Thr Uncertain significance Single submitter
- IL6 p.Met95Ile Uncertain significance Single submitter
- IL6 p.Tyr59His Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- IL6 p.Asp162Val Benign Multiple submitters
- IL6 p.Arg141Ile Uncertain significance Single submitter
- IL6 p.Arg196Ser Uncertain significance Single submitter
- IL6 p.Arg207Thr Uncertain significance Single submitter
- IL6 p.Glu109Gly Uncertain significance Single submitter
- IL6 p.Glu87Asp Uncertain significance Single submitter
- IL6 p.Lys157Thr Uncertain significance Single submitter
- IL6 p.Lys55Glu Likely benign Single submitter
All IL6 variants
Benign 4
- p.Asp162Val Multiple submitters ⚠
- p.Pro31Thr Single submitter
- p.Pro32Ser Single submitter
- p.Phe201= No assertion criteria IL6-related disorder
Likely benign 4
- p.Leu61= Multiple submitters
- p.Ser65= Multiple submitters
- p.Gln56His Single submitter
- p.Lys55Glu Single submitter ⚠
Uncertain significance 12
- p.Ala40Asp Single submitter ⚠
- p.Arg141Ile Single submitter ⚠
- p.Arg196Ser Single submitter ⚠
- p.Arg207Thr Single submitter ⚠
- p.Asn183Lys Single submitter ⚠
- p.Asn73Ser Single submitter ⚠
- p.Glu109Gly Single submitter ⚠
- p.Glu87Asp Single submitter ⚠
- p.Lys157Thr Single submitter ⚠
- p.Lys178Thr Single submitter ⚠
- p.Met95Ile Single submitter ⚠
- p.Tyr59His Single submitter ⚠