IMP4 — 59 ClinVar variants
All ClinVar germline IMP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Likely benign · 58 Uncertain significance
Full IMP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IMP4 p.Ala21Val Uncertain significance Single submitter
- IMP4 p.Ala282Thr Uncertain significance Single submitter
- IMP4 p.Arg126Gln Uncertain significance Single submitter
- IMP4 p.Arg170Trp Uncertain significance Single submitter
- IMP4 p.Arg198Gln Uncertain significance Single submitter
- IMP4 p.Arg204Gln Uncertain significance Single submitter
- IMP4 p.Arg216Gln Uncertain significance Single submitter
- IMP4 p.Arg216Trp Uncertain significance Single submitter
- IMP4 p.Arg23Leu Uncertain significance Single submitter
- IMP4 p.Arg250His Uncertain significance Single submitter
- IMP4 p.Arg259His Uncertain significance Single submitter
- IMP4 p.Arg274Cys Uncertain significance Single submitter
- IMP4 p.Arg283Cys Uncertain significance Single submitter
- IMP4 p.Arg40His Uncertain significance Single submitter
- IMP4 p.Arg48Gln Uncertain significance Single submitter
- IMP4 p.Arg4Pro Uncertain significance Single submitter
- IMP4 p.Arg76Gln Uncertain significance Single submitter
- IMP4 p.Asn39Ser Uncertain significance Single submitter
- IMP4 p.Asp135His Uncertain significance Single submitter
- IMP4 p.Asp213Glu Uncertain significance Single submitter
- IMP4 p.Gln54Arg Uncertain significance Single submitter
- IMP4 p.Glu246Lys Uncertain significance Single submitter
- IMP4 p.Glu291Lys Uncertain significance Single submitter
- IMP4 p.Glu81Lys Uncertain significance Single submitter
- IMP4 p.Gly132Ser Uncertain significance Single submitter
- IMP4 p.Gly64Val Uncertain significance Single submitter
- IMP4 p.His239Asp Uncertain significance Single submitter
- IMP4 p.Ile202Val Uncertain significance Single submitter
- IMP4 p.Ile87Val Uncertain significance Single submitter
- IMP4 p.Leu104Val Uncertain significance Single submitter
- IMP4 p.Met86Val Uncertain significance Single submitter
- IMP4 p.Phe108Ile Uncertain significance Single submitter
- IMP4 p.Pro109Leu Uncertain significance Single submitter
- IMP4 p.Pro155Leu Uncertain significance Single submitter
- IMP4 p.Pro158Leu Uncertain significance Single submitter
- IMP4 p.Pro184Leu Uncertain significance Single submitter
- IMP4 p.Pro208Arg Uncertain significance Single submitter
- IMP4 p.Ser193Phe Uncertain significance Single submitter
- IMP4 p.Thr159Ile Uncertain significance Single submitter
- IMP4 p.Thr237Ile Uncertain significance Single submitter
- IMP4 p.Val151Ile Uncertain significance Single submitter
- IMP4 p.Val233Met Uncertain significance Single submitter
- IMP4 p.Val247Ile Uncertain significance Single submitter
- IMP4 p.Val71Met Uncertain significance Single submitter
- IMP4 p.Val80Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- IMP4 p.Arg194Cys Uncertain significance Single submitter
- IMP4 p.Arg28Ser Uncertain significance Single submitter
- IMP4 p.Arg40Cys Uncertain significance Single submitter
- IMP4 p.Arg47His Uncertain significance Single submitter
- IMP4 p.Met169Ile Uncertain significance Single submitter
- IMP4 p.Met257Ile Uncertain significance Single submitter
- IMP4 p.Phe207Leu Uncertain significance Single submitter
- IMP4 p.Trp275Arg Uncertain significance Single submitter
- IMP4 p.Tyr161Cys Uncertain significance Single submitter
- IMP4 p.Val151Ala Uncertain significance Single submitter
- IMP4 p.Val209Leu Uncertain significance Single submitter
All IMP4 variants
Likely benign 1
- p.Arg283His Single submitter
Uncertain significance 58
- p.Ala21Val Single submitter ⚠
- p.Ala282Thr Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg170Trp Single submitter ⚠
- p.Arg194Cys Single submitter ⚠
- p.Arg198Gln Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg216Trp Single submitter ⚠
- p.Arg23Leu Single submitter ⚠
- p.Arg250Cys Single submitter
- p.Arg250His Single submitter ⚠
- p.Arg259His Single submitter ⚠
- p.Arg274Cys Single submitter ⚠
- p.Arg283Cys Single submitter ⚠
- p.Arg28Ser Single submitter ⚠
- p.Arg40Cys Single submitter ⚠
- p.Arg40His Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg4Pro Single submitter ⚠
- p.Arg76Gln Single submitter ⚠
- p.Asn39Ser Single submitter ⚠
- p.Asp135His Single submitter ⚠
- p.Asp213Glu Single submitter ⚠
- p.Gln54Arg Single submitter ⚠
- p.Glu246Lys Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu81Lys Single submitter ⚠
- p.Gly132Ser Single submitter ⚠
- p.Gly64Val Single submitter ⚠
- p.His239Asp Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu104Val Single submitter ⚠
- p.Leu106Val Single submitter
- p.Met169Ile Single submitter ⚠
- p.Met257Ile Single submitter ⚠
- p.Met86Val Single submitter ⚠
- p.Phe108Ile Single submitter ⚠
- p.Phe207Leu Single submitter ⚠
- p.Pro109Leu Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro158Leu Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Pro208Arg Single submitter ⚠
- p.Ser193Phe Single submitter ⚠
- p.Thr159Ile Single submitter ⚠
- p.Thr237Ile Single submitter ⚠
- p.Trp275Arg Single submitter ⚠
- p.Tyr161Cys Single submitter ⚠
- p.Val151Ala Single submitter ⚠
- p.Val151Ile Single submitter ⚠
- p.Val209Leu Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val247Ile Single submitter ⚠
- p.Val71Met Single submitter ⚠
- p.Val80Ile Single submitter ⚠