Sugi Variant

Sugi Variant/IMPG2

IMPG2 — 1188 ClinVar variants

All ClinVar germline IMPG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 552 flagged for review →

63 Pathogenic · 30 Pathogenic/Likely pathogenic · 63 Likely pathogenic · 63 Conflicting · 20 Benign · 8 Benign/Likely benign · 275 Likely benign · 666 Uncertain significance

Full IMPG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 552

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 29

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 463

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 463

Predictors split 60

The independent predictors disagree with each other — read with care.

All IMPG2 variants

Pathogenic 63

Pathogenic/Likely pathogenic 30

Likely pathogenic 63

Conflicting classifications of pathogenicity 63

Benign 20

Benign/Likely benign 8

Likely benign 275

Uncertain significance 666

Showing the top 300 by review status; the full set is in the sitemap.