INA — 66 ClinVar variants
All ClinVar germline INA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Likely pathogenic · 2 Likely benign · 63 Uncertain significance
Full INA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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INA p.Gly188Arg
Likely pathogenic
Single submitter
Abnormal brain morphology
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INA p.Ala152Ser Uncertain significance Single submitter
- INA p.Ala27Thr Uncertain significance Single submitter
- INA p.Ala332Thr Uncertain significance Single submitter
- INA p.Ala455Pro Uncertain significance Single submitter
- INA p.Ala49Val Uncertain significance Single submitter
- INA p.Ala53Ser Uncertain significance Single submitter
- INA p.Ala65Thr Uncertain significance Single submitter
- INA p.Arg28His Uncertain significance Single submitter
- INA p.Arg377Gln Uncertain significance Single submitter
- INA p.Arg68Leu Uncertain significance Single submitter
- INA p.Asn293Ser Uncertain significance Single submitter
- INA p.Asn47Ser Uncertain significance Single submitter
- INA p.Asn85Ser Uncertain significance Single submitter
- INA p.Asn93Lys Uncertain significance Single submitter
- INA p.Asp169His Uncertain significance Single submitter
- INA p.Asp364Tyr Uncertain significance Single submitter
- INA p.Asp73Glu Uncertain significance Single submitter
- INA p.Gln131Arg Uncertain significance Single submitter
- INA p.Glu174Asp Uncertain significance Single submitter
- INA p.Glu184Ala Uncertain significance Single submitter
- INA p.Gly170Glu Uncertain significance Single submitter
- INA p.Gly191Ser Uncertain significance Single submitter
- INA p.Gly37Asp Uncertain significance Single submitter
- INA p.Ile391Thr Uncertain significance Single submitter
- INA p.Ile479Thr Uncertain significance Single submitter
- INA p.Leu208Pro Uncertain significance Single submitter
- INA p.Leu383Phe Uncertain significance Single submitter
- INA p.Leu9Val Uncertain significance Single submitter
- INA p.Lys290Arg Uncertain significance Single submitter
- INA p.Lys498Arg Uncertain significance Single submitter
- INA p.Pro70Leu Uncertain significance Single submitter
- INA p.Ser158Gly Uncertain significance Single submitter
- INA p.Ser415Leu Uncertain significance Single submitter
- INA p.Ser460Pro Uncertain significance Single submitter
- INA p.Thr323Ile Uncertain significance Single submitter
- INA p.Thr368Asn Uncertain significance Single submitter
- INA p.Thr405Lys Uncertain significance Single submitter
- INA p.Thr442Ser Uncertain significance Single submitter
- INA p.Thr84Ala Uncertain significance Single submitter
- INA p.Thr84Asn Uncertain significance Single submitter
- INA p.Tyr8His Uncertain significance Single submitter
- INA p.Val203Met Uncertain significance Single submitter
- INA p.Val256Leu Uncertain significance Single submitter
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INA p.Glu267Lys
Uncertain significance
No assertion criteria
High myopia
Predictors split 16
The independent predictors disagree with each other — read with care.
- INA p.Ala283Ser Uncertain significance Single submitter
- INA p.Arg161His Uncertain significance Single submitter
- INA p.Arg187Cys Uncertain significance Single submitter
- INA p.Arg24His Uncertain significance Single submitter
- INA p.Arg322Leu Uncertain significance Single submitter
- INA p.Asp21His Uncertain significance Single submitter
- INA p.Glu155Gly Uncertain significance Single submitter
- INA p.Glu193Gln Uncertain significance Single submitter
- INA p.Glu233Lys Uncertain significance Single submitter
- INA p.Gly20Arg Uncertain significance Single submitter
- INA p.Gly20Val Uncertain significance Single submitter
- INA p.Ile358Thr Uncertain significance Single submitter
- INA p.Leu98Val Uncertain significance Single submitter
- INA p.Phe105Leu Uncertain significance Single submitter
- INA p.Ser2Asn Uncertain significance Single submitter
- INA p.Val252Met Uncertain significance Single submitter
All INA variants
Likely pathogenic 1
- p.Gly188Arg Single submitter Abnormal brain morphology ⚠
Uncertain significance 63
- p.Ala152Ser Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala283Ser Single submitter ⚠
- p.Ala332Thr Single submitter ⚠
- p.Ala455Pro Single submitter ⚠
- p.Ala49Val Single submitter ⚠
- p.Ala53Ser Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg24His Single submitter ⚠
- p.Arg28His Single submitter ⚠
- p.Arg322Leu Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg68Leu Single submitter ⚠
- p.Asn293Ser Single submitter ⚠
- p.Asn47Ser Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asn93Lys Single submitter ⚠
- p.Asp169His Single submitter ⚠
- p.Asp21His Single submitter ⚠
- p.Asp364Tyr Single submitter ⚠
- p.Asp73Glu Single submitter ⚠
- p.Asp73Tyr Single submitter
- p.Gln131Arg Single submitter ⚠
- p.Glu155Gly Single submitter ⚠
- p.Glu174Asp Single submitter ⚠
- p.Glu184Ala Single submitter ⚠
- p.Glu193Gln Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Gly170Glu Single submitter ⚠
- p.Gly191Ser Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly20Val Single submitter ⚠
- p.Gly37Asp Single submitter ⚠
- p.Gly74Trp Single submitter
- p.Ile358Thr Single submitter ⚠
- p.Ile391Thr Single submitter ⚠
- p.Ile479Thr Single submitter ⚠
- p.Leu208Pro Single submitter ⚠
- p.Leu383Phe Single submitter ⚠
- p.Leu98Val Single submitter ⚠
- p.Leu9Val Single submitter ⚠
- p.Lys290Arg Single submitter ⚠
- p.Lys498Arg Single submitter ⚠
- p.Phe105Leu Single submitter ⚠
- p.Phe3Cys Single submitter
- p.Pro70Leu Single submitter ⚠
- p.Ser158Gly Single submitter ⚠
- p.Ser2Asn Single submitter ⚠
- p.Ser415Leu Single submitter ⚠
- p.Ser460Pro Single submitter ⚠
- p.Thr323Ile Single submitter ⚠
- p.Thr368Asn Single submitter ⚠
- p.Thr405Lys Single submitter ⚠
- p.Thr442Ser Single submitter ⚠
- p.Thr84Ala Single submitter ⚠
- p.Thr84Asn Single submitter ⚠
- p.Tyr8His Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val252Met Single submitter ⚠
- p.Val256Leu Single submitter ⚠
- p.Glu267Lys No assertion criteria High myopia ⚠