ING2 — 18 ClinVar variants
All ClinVar germline ING2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
18 Uncertain significance
Full ING2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ING2 p.Ala134Asp Uncertain significance Single submitter
- ING2 p.Arg161His Uncertain significance Single submitter
- ING2 p.Arg22Gln Uncertain significance Single submitter
- ING2 p.Asn218Asp Uncertain significance Single submitter
- ING2 p.Asp172Val Uncertain significance Single submitter
- ING2 p.Cys26Tyr Uncertain significance Single submitter
- ING2 p.Glu19Lys Uncertain significance Single submitter
- ING2 p.Leu32Phe Uncertain significance Single submitter
- ING2 p.Leu38Pro Uncertain significance Single submitter
- ING2 p.Pro177Leu Uncertain significance Single submitter
- ING2 p.Pro178Thr Uncertain significance Single submitter
- ING2 p.Ser160Asn Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ING2 variants
Uncertain significance 18
- p.Ala134Asp Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg81Cys Single submitter
- p.Asn218Asp Single submitter ⚠
- p.Asp172Val Single submitter ⚠
- p.Cys26Tyr Single submitter ⚠
- p.Gln6Lys Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu19Lys Single submitter ⚠
- p.Ile103Thr Single submitter ⚠
- p.Leu32Phe Single submitter ⚠
- p.Leu38Pro Single submitter ⚠
- p.Met266Thr Single submitter ⚠
- p.Pro177Leu Single submitter ⚠
- p.Pro178Thr Single submitter ⚠
- p.Ser160Asn Single submitter ⚠
- p.Val46Met Single submitter ⚠