Sugi Variant

Sugi Variant/INO80

INO80 — 236 ClinVar variants

All ClinVar germline INO80 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 153 flagged for review →

2 Likely pathogenic · 2 Conflicting · 13 Benign · 2 Benign/Likely benign · 56 Likely benign · 161 Uncertain significance

Full INO80 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 153

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 116

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 35

The independent predictors disagree with each other — read with care.

All INO80 variants

Likely pathogenic 2

Conflicting classifications of pathogenicity 2

Benign 13

Benign/Likely benign 2

Likely benign 56

Uncertain significance 161