INPP5A — 57 ClinVar variants
All ClinVar germline INPP5A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Benign · 2 Likely benign · 53 Uncertain significance
Full INPP5A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INPP5A p.Ala333Thr Uncertain significance Single submitter
- INPP5A p.Ala403Ser Uncertain significance Single submitter
- INPP5A p.Ala7Val Uncertain significance Single submitter
- INPP5A p.Arg206Trp Uncertain significance Single submitter
- INPP5A p.Arg221Gln Uncertain significance Single submitter
- INPP5A p.Arg236Gln Uncertain significance Single submitter
- INPP5A p.Arg275Gln Uncertain significance Single submitter
- INPP5A p.Arg295Gln Uncertain significance Single submitter
- INPP5A p.Arg334Cys Uncertain significance Single submitter
- INPP5A p.Arg35Gln Uncertain significance Single submitter
- INPP5A p.Arg393Gln Uncertain significance Single submitter
- INPP5A p.Asn116Asp Uncertain significance Single submitter
- INPP5A p.Asn261Ser Uncertain significance Single submitter
- INPP5A p.Asp138Gly Uncertain significance Single submitter
- INPP5A p.Asp287Glu Uncertain significance Single submitter
- INPP5A p.Asp287His Uncertain significance Single submitter
- INPP5A p.Asp69Gly Uncertain significance Single submitter
- INPP5A p.Cys53Ser Uncertain significance Single submitter
- INPP5A p.Glu27Lys Uncertain significance Single submitter
- INPP5A p.Glu83Lys Uncertain significance Single submitter
- INPP5A p.Gly397Arg Uncertain significance Single submitter
- INPP5A p.His402Arg Uncertain significance Single submitter
- INPP5A p.Ile117Met Uncertain significance Single submitter
- INPP5A p.Ile267Val Uncertain significance Single submitter
- INPP5A p.Lys307Arg Uncertain significance Single submitter
- INPP5A p.Lys31Asn Uncertain significance Single submitter
- INPP5A p.Met252Thr Uncertain significance Single submitter
- INPP5A p.Met65Thr Uncertain significance Single submitter
- INPP5A p.Pro8Ser Uncertain significance Single submitter
- INPP5A p.Ser271Leu Uncertain significance Single submitter
- INPP5A p.Thr10Ile Uncertain significance Single submitter
- INPP5A p.Thr372Ile Uncertain significance Single submitter
- INPP5A p.Tyr136Cys Uncertain significance Single submitter
- INPP5A p.Tyr212His Uncertain significance Single submitter
- INPP5A p.Tyr84Cys Uncertain significance Single submitter
- INPP5A p.Val12Leu Uncertain significance Single submitter
- INPP5A p.Val243Leu Uncertain significance Single submitter
- INPP5A p.Val277Ile Uncertain significance Single submitter
- INPP5A p.Val361Leu Uncertain significance Single submitter
- INPP5A p.Val370Ile Uncertain significance Single submitter
- INPP5A p.Val380Ile Uncertain significance Single submitter
- INPP5A p.Val405Met Uncertain significance Single submitter
- INPP5A p.Val72Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- INPP5A p.Arg35Pro Uncertain significance Single submitter
- INPP5A p.Asn60Lys Uncertain significance Single submitter
- INPP5A p.Gly9Ser Uncertain significance Single submitter
- INPP5A p.Leu140Phe Uncertain significance Single submitter
- INPP5A p.Val225Phe Uncertain significance Single submitter
- INPP5A p.Val411Met Uncertain significance Single submitter
All INPP5A variants
Uncertain significance 53
- c.1158+1G>A Single submitter
- c.828+1G>A Single submitter
- p.Ala333Thr Single submitter ⚠
- p.Ala403Ser Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg206Trp Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg275Gln Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg334Cys Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Arg35Pro Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Asn116Asp Single submitter ⚠
- p.Asn261Ser Single submitter ⚠
- p.Asn60Lys Single submitter ⚠
- p.Asp138Gly Single submitter ⚠
- p.Asp287Glu Single submitter ⚠
- p.Asp287His Single submitter ⚠
- p.Asp69Gly Single submitter ⚠
- p.Cys53Ser Single submitter ⚠
- p.Glu27Lys Single submitter ⚠
- p.Glu36Ala Single submitter
- p.Glu83Lys Single submitter ⚠
- p.Gly397Arg Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.His402Arg Single submitter ⚠
- p.Ile117Met Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Leu140Phe Single submitter ⚠
- p.Lys307Arg Single submitter ⚠
- p.Lys31Asn Single submitter ⚠
- p.Met252Thr Single submitter ⚠
- p.Met65Thr Single submitter ⚠
- p.Pro8Ser Single submitter ⚠
- p.Ser271Leu Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr372Ile Single submitter ⚠
- p.Tyr136Cys Single submitter ⚠
- p.Tyr212His Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val12Leu Single submitter ⚠
- p.Val225Phe Single submitter ⚠
- p.Val243Leu Single submitter ⚠
- p.Val277Ile Single submitter ⚠
- p.Val361Leu Single submitter ⚠
- p.Val370Ile Single submitter ⚠
- p.Val380Ile Single submitter ⚠
- p.Val405Met Single submitter ⚠
- p.Val411Met Single submitter ⚠
- p.Val41Met Single submitter
- p.Val72Ile Single submitter ⚠