Sugi Variant

Sugi Variant/INPPL1

INPPL1 — 721 ClinVar variants

All ClinVar germline INPPL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 295 flagged for review →

22 Pathogenic · 3 Pathogenic/Likely pathogenic · 19 Likely pathogenic · 8 Conflicting · 32 Benign · 11 Benign/Likely benign · 303 Likely benign · 323 Uncertain significance

Full INPPL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 295

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 226

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 226

Predictors split 63

The independent predictors disagree with each other — read with care.

All INPPL1 variants

Pathogenic 22

Pathogenic/Likely pathogenic 3

Likely pathogenic 19

Conflicting classifications of pathogenicity 8

Benign 32

Benign/Likely benign 11

Likely benign 303

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 323

Showing the top 300 by review status; the full set is in the sitemap.