INSYN2A — 102 ClinVar variants
All ClinVar germline INSYN2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
7 Likely benign · 95 Uncertain significance
Full INSYN2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 80
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INSYN2A p.Ala164Thr Uncertain significance Single submitter
- INSYN2A p.Ala164Val Uncertain significance Single submitter
- INSYN2A p.Ala208Gly Uncertain significance Single submitter
- INSYN2A p.Ala208Val Uncertain significance Single submitter
- INSYN2A p.Ala21Thr Uncertain significance Single submitter
- INSYN2A p.Ala22Thr Uncertain significance Single submitter
- INSYN2A p.Ala258Thr Uncertain significance Single submitter
- INSYN2A p.Ala25Ser Uncertain significance Single submitter
- INSYN2A p.Ala274Val Uncertain significance Single submitter
- INSYN2A p.Ala276Thr Uncertain significance Single submitter
- INSYN2A p.Ala339Val Uncertain significance Single submitter
- INSYN2A p.Ala82Thr Uncertain significance Single submitter
- INSYN2A p.Arg160Gln Uncertain significance Single submitter
- INSYN2A p.Arg160Trp Uncertain significance Single submitter
- INSYN2A p.Arg166Trp Uncertain significance Single submitter
- INSYN2A p.Arg214Gln Uncertain significance Single submitter
- INSYN2A p.Arg232Gln Uncertain significance Single submitter
- INSYN2A p.Arg232Trp Uncertain significance Single submitter
- INSYN2A p.Arg234Ser Uncertain significance Single submitter
- INSYN2A p.Arg288Trp Uncertain significance Single submitter
- INSYN2A p.Arg290Gly Uncertain significance Single submitter
- INSYN2A p.Arg399Trp Uncertain significance Single submitter
- INSYN2A p.Arg81Lys Uncertain significance Single submitter
- INSYN2A p.Asn140Asp Uncertain significance Single submitter
- INSYN2A p.Asn141Ser Uncertain significance Single submitter
- INSYN2A p.Asn367His Uncertain significance Single submitter
- INSYN2A p.Asp110Asn Uncertain significance Single submitter
- INSYN2A p.Asp221Asn Uncertain significance Single submitter
- INSYN2A p.Asp221Tyr Uncertain significance Single submitter
- INSYN2A p.Asp285Val Uncertain significance Single submitter
- INSYN2A p.Asp357Asn Uncertain significance Single submitter
- INSYN2A p.Cys9Tyr Uncertain significance Single submitter
- INSYN2A p.Gln324His Uncertain significance Single submitter
- INSYN2A p.Glu152Gln Uncertain significance Single submitter
- INSYN2A p.Glu158Lys Uncertain significance Single submitter
- INSYN2A p.Glu15Asp Uncertain significance Single submitter
- INSYN2A p.Glu218Lys Uncertain significance Single submitter
- INSYN2A p.Glu238Lys Uncertain significance Single submitter
- INSYN2A p.Glu267Lys Uncertain significance Single submitter
- INSYN2A p.Glu287Gln Uncertain significance Single submitter
- INSYN2A p.Glu287Lys Uncertain significance Single submitter
- INSYN2A p.Glu317Lys Uncertain significance Single submitter
- INSYN2A p.Gly154Val Uncertain significance Single submitter
- INSYN2A p.Gly163Ser Uncertain significance Single submitter
- INSYN2A p.Gly205Ala Uncertain significance Single submitter
- INSYN2A p.Gly233Glu Uncertain significance Single submitter
- INSYN2A p.Gly296Arg Uncertain significance Single submitter
- INSYN2A p.Gly70Arg Uncertain significance Single submitter
- INSYN2A p.His176Arg Uncertain significance Single submitter
- INSYN2A p.His293Asn Uncertain significance Single submitter
- INSYN2A p.Ile349Thr Uncertain significance Single submitter
- INSYN2A p.Ile441Thr Uncertain significance Single submitter
- INSYN2A p.Ile447Val Uncertain significance Single submitter
- INSYN2A p.Leu11Phe Uncertain significance Single submitter
- INSYN2A p.Leu127Phe Uncertain significance Single submitter
- INSYN2A p.Leu225Ile Uncertain significance Single submitter
- INSYN2A p.Lys169Glu Uncertain significance Single submitter
- INSYN2A p.Lys437Gln Uncertain significance Single submitter
- INSYN2A p.Phe249Ile Uncertain significance Single submitter
- INSYN2A p.Pro199Leu Uncertain significance Single submitter
- INSYN2A p.Pro266Ser Uncertain significance Single submitter
- INSYN2A p.Pro309Ser Uncertain significance Single submitter
- INSYN2A p.Pro309Thr Uncertain significance Single submitter
- INSYN2A p.Pro310Leu Uncertain significance Single submitter
- INSYN2A p.Pro322Leu Uncertain significance Single submitter
- INSYN2A p.Pro460Thr Uncertain significance Single submitter
- INSYN2A p.Ser217Pro Uncertain significance Single submitter
- INSYN2A p.Ser301Leu Uncertain significance Single submitter
- INSYN2A p.Ser319Asn Uncertain significance Single submitter
- INSYN2A p.Ser449Pro Uncertain significance Single submitter
- INSYN2A p.Ser65Thr Uncertain significance Single submitter
- INSYN2A p.Thr183Ile Uncertain significance Single submitter
- INSYN2A p.Thr325Ile Uncertain significance Single submitter
- INSYN2A p.Thr353Met Uncertain significance Single submitter
- INSYN2A p.Thr6Ile Uncertain significance Single submitter
- INSYN2A p.Tyr84His Uncertain significance Single submitter
- INSYN2A p.Val174Leu Uncertain significance Single submitter
- INSYN2A p.Val190Ala Uncertain significance Single submitter
- INSYN2A p.Val256Ile Uncertain significance Single submitter
- INSYN2A p.Val99Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- INSYN2A p.Arg122Cys Uncertain significance Single submitter
- INSYN2A p.Arg41Gln Uncertain significance Single submitter
- INSYN2A p.Arg93Cys Uncertain significance Single submitter
- INSYN2A p.Arg94Thr Uncertain significance Single submitter
- INSYN2A p.Gly389Glu Uncertain significance Single submitter
- INSYN2A p.Gly472Arg Uncertain significance Single submitter
- INSYN2A p.Leu111Phe Uncertain significance Single submitter
- INSYN2A p.Met88Thr Uncertain significance Single submitter
- INSYN2A p.Pro97Ala Uncertain significance Single submitter
- INSYN2A p.Ser108Leu Uncertain significance Single submitter
- INSYN2A p.Val105Met Uncertain significance Single submitter
All INSYN2A variants
Likely benign 7
- p.Arg288Gln Single submitter
- p.Lys112Arg Single submitter
- p.Pro201Leu Single submitter
- p.Pro20Ser Single submitter
- p.Thr13Ala Single submitter
- p.Thr6Ser Single submitter
- p.Val340Ala Single submitter
Uncertain significance 95
- p.Ala164Thr Single submitter ⚠
- p.Ala164Val Single submitter ⚠
- p.Ala208Gly Single submitter ⚠
- p.Ala208Val Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala258Thr Single submitter ⚠
- p.Ala25Ser Single submitter ⚠
- p.Ala274Val Single submitter ⚠
- p.Ala276Thr Single submitter ⚠
- p.Ala339Val Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg122His Single submitter
- p.Arg160Gln Single submitter ⚠
- p.Arg160Trp Single submitter ⚠
- p.Arg166Trp Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg232Gln Single submitter ⚠
- p.Arg232Trp Single submitter ⚠
- p.Arg234Ser Single submitter ⚠
- p.Arg288Trp Single submitter ⚠
- p.Arg290Gly Single submitter ⚠
- p.Arg399Trp Single submitter ⚠
- p.Arg41fs Single submitter
- p.Arg41Gln Single submitter ⚠
- p.Arg81Lys Single submitter ⚠
- p.Arg85Cys Single submitter
- p.Arg85His Single submitter
- p.Arg93Cys Single submitter ⚠
- p.Arg94Thr Single submitter ⚠
- p.Asn140Asp Single submitter ⚠
- p.Asn141Ser Single submitter ⚠
- p.Asn367His Single submitter ⚠
- p.Asp110Asn Single submitter ⚠
- p.Asp221Asn Single submitter ⚠
- p.Asp221Tyr Single submitter ⚠
- p.Asp285Val Single submitter ⚠
- p.Asp357Asn Single submitter ⚠
- p.Cys9Tyr Single submitter ⚠
- p.Gln324His Single submitter ⚠
- p.Glu152Gln Single submitter ⚠
- p.Glu158Lys Single submitter ⚠
- p.Glu15Asp Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Glu238Lys Single submitter ⚠
- p.Glu267Lys Single submitter ⚠
- p.Glu287Gln Single submitter ⚠
- p.Glu287Lys Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Gly154Val Single submitter ⚠
- p.Gly163Ser Single submitter ⚠
- p.Gly205Ala Single submitter ⚠
- p.Gly233Glu Single submitter ⚠
- p.Gly296Arg Single submitter ⚠
- p.Gly389Glu Single submitter ⚠
- p.Gly472Arg Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.His176Arg Single submitter ⚠
- p.His293Asn Single submitter ⚠
- p.Ile349Thr Single submitter ⚠
- p.Ile441Thr Single submitter ⚠
- p.Ile447Val Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Leu127Phe Single submitter ⚠
- p.Leu225Ile Single submitter ⚠
- p.Lys169Glu Single submitter ⚠
- p.Lys437Gln Single submitter ⚠
- p.Met88Thr Single submitter ⚠
- p.Phe249Ile Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Pro266Ser Single submitter ⚠
- p.Pro309Ser Single submitter ⚠
- p.Pro309Thr Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Pro322Leu Single submitter ⚠
- p.Pro460Thr Single submitter ⚠
- p.Pro97Ala Single submitter ⚠
- p.Ser108Leu Single submitter ⚠
- p.Ser217Pro Single submitter ⚠
- p.Ser301Leu Single submitter ⚠
- p.Ser319Asn Single submitter ⚠
- p.Ser449Pro Single submitter ⚠
- p.Ser65Thr Single submitter ⚠
- p.Thr183Ile Single submitter ⚠
- p.Thr325Ile Single submitter ⚠
- p.Thr353Met Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Tyr84His Single submitter ⚠
- p.Val105Met Single submitter ⚠
- p.Val174Leu Single submitter ⚠
- p.Val190Ala Single submitter ⚠
- p.Val256Ile Single submitter ⚠
- p.Val99Ile Single submitter ⚠