INTS9 — 91 ClinVar variants
All ClinVar germline INTS9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
3 Likely benign · 88 Uncertain significance
Full INTS9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INTS9 p.Leu417Pro Uncertain significance Multiple submitters
- INTS9 p.Ala208Val Uncertain significance Single submitter
- INTS9 p.Ala286Asp Uncertain significance Single submitter
- INTS9 p.Ala319Val Uncertain significance Single submitter
- INTS9 p.Ala506Thr Uncertain significance Single submitter
- INTS9 p.Ala560Thr Uncertain significance Single submitter
- INTS9 p.Arg401Cys Uncertain significance Single submitter
- INTS9 p.Arg401His Uncertain significance Single submitter
- INTS9 p.Arg500Gln Uncertain significance Single submitter
- INTS9 p.Arg500Trp Uncertain significance Single submitter
- INTS9 p.Arg501Gln Uncertain significance Single submitter
- INTS9 p.Arg512Gln Uncertain significance Single submitter
- INTS9 p.Arg558Gln Uncertain significance Single submitter
- INTS9 p.Arg570Trp Uncertain significance Single submitter
- INTS9 p.Asn284His Uncertain significance Single submitter
- INTS9 p.Asp171Asn Uncertain significance Single submitter
- INTS9 p.Asp386Asn Uncertain significance Single submitter
- INTS9 p.Asp449Asn Uncertain significance Single submitter
- INTS9 p.Asp491Asn Uncertain significance Single submitter
- INTS9 p.Asp524His Uncertain significance Single submitter
- INTS9 p.Asp573Asn Uncertain significance Single submitter
- INTS9 p.Asp574Gly Uncertain significance Single submitter
- INTS9 p.Asp65Ala Uncertain significance Single submitter
- INTS9 p.Cys14Gly Uncertain significance Single submitter
- INTS9 p.Cys299Tyr Uncertain significance Single submitter
- INTS9 p.Gln228Glu Uncertain significance Single submitter
- INTS9 p.Gln477Lys Uncertain significance Single submitter
- INTS9 p.Glu145Gln Uncertain significance Single submitter
- INTS9 p.Glu517Lys Uncertain significance Single submitter
- INTS9 p.Gly118Ser Uncertain significance Single submitter
- INTS9 p.Gly396Arg Uncertain significance Single submitter
- INTS9 p.Ile113Val Uncertain significance Single submitter
- INTS9 p.Ile132Met Uncertain significance Single submitter
- INTS9 p.Ile144Thr Uncertain significance Single submitter
- INTS9 p.Ile589Leu Uncertain significance Single submitter
- INTS9 p.Leu205His Uncertain significance Single submitter
- INTS9 p.Leu263Met Uncertain significance Single submitter
- INTS9 p.Leu296Ser Uncertain significance Single submitter
- INTS9 p.Leu430Gln Uncertain significance Single submitter
- INTS9 p.Leu544Arg Uncertain significance Single submitter
- INTS9 p.Met137Val Uncertain significance Single submitter
- INTS9 p.Met184Leu Uncertain significance Single submitter
- INTS9 p.Met529Leu Uncertain significance Single submitter
- INTS9 p.Met642Thr Uncertain significance Single submitter
- INTS9 p.Pro213Arg Uncertain significance Single submitter
- INTS9 p.Pro438Leu Uncertain significance Single submitter
- INTS9 p.Pro495Ala Uncertain significance Single submitter
- INTS9 p.Pro583Thr Uncertain significance Single submitter
- INTS9 p.Pro590Ser Uncertain significance Single submitter
- INTS9 p.Ser56Cys Uncertain significance Single submitter
- INTS9 p.Ser79Ala Uncertain significance Single submitter
- INTS9 p.Thr120Ile Uncertain significance Single submitter
- INTS9 p.Thr126Met Uncertain significance Single submitter
- INTS9 p.Thr88Met Uncertain significance Single submitter
- INTS9 p.Tyr182Cys Uncertain significance Single submitter
- INTS9 p.Val130Ile Uncertain significance Single submitter
- INTS9 p.Val324Phe Uncertain significance Single submitter
- INTS9 p.Val405Ala Uncertain significance Single submitter
- INTS9 p.Val591Met Uncertain significance Single submitter
- INTS9 p.Val617Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- INTS9 p.Arg648Gln Uncertain significance Single submitter
- INTS9 p.Cys181Tyr Uncertain significance Single submitter
- INTS9 p.Glu609Val Uncertain significance Single submitter
- INTS9 p.Glu641Lys Uncertain significance Single submitter
- INTS9 p.Glu70Lys Uncertain significance Single submitter
- INTS9 p.Gly265Glu Uncertain significance Single submitter
- INTS9 p.Gly381Arg Uncertain significance Single submitter
- INTS9 p.Gly614Ser Uncertain significance Single submitter
- INTS9 p.Ile628Thr Uncertain significance Single submitter
- INTS9 p.Lys459Glu Uncertain significance Single submitter
- INTS9 p.Phe38Leu Uncertain significance Single submitter
- INTS9 p.Phe83Cys Uncertain significance Single submitter
- INTS9 p.Pro398Ser Uncertain significance Single submitter
- INTS9 p.Pro556Thr Uncertain significance Single submitter
- INTS9 p.Pro81Leu Uncertain significance Single submitter
- INTS9 p.Ser254Phe Uncertain significance Single submitter
- INTS9 p.Thr11Ile Uncertain significance Single submitter
- INTS9 p.Thr95Ile Uncertain significance Single submitter
- INTS9 p.Tyr231Asp Uncertain significance Single submitter
- INTS9 p.Val393Leu Uncertain significance Single submitter
- INTS9 p.Val651Phe Uncertain significance Single submitter
- INTS9 p.Val75Ala Uncertain significance Single submitter
All INTS9 variants
Likely benign 3
- p.Asn51Ser Single submitter
- p.Leu309= Single submitter
- p.Val575Ile Single submitter
Uncertain significance 88
- p.Leu417Pro Multiple submitters ⚠
- p.Ala208Val Single submitter ⚠
- p.Ala286Asp Single submitter ⚠
- p.Ala319Val Single submitter ⚠
- p.Ala506Thr Single submitter ⚠
- p.Ala560Thr Single submitter ⚠
- p.Arg401Cys Single submitter ⚠
- p.Arg401His Single submitter ⚠
- p.Arg500Gln Single submitter ⚠
- p.Arg500Trp Single submitter ⚠
- p.Arg501Gln Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg512Trp Single submitter
- p.Arg558Gln Single submitter ⚠
- p.Arg570Trp Single submitter ⚠
- p.Arg648Gln Single submitter ⚠
- p.Asn224Ser Single submitter
- p.Asn284His Single submitter ⚠
- p.Asp171Asn Single submitter ⚠
- p.Asp259Asn Single submitter
- p.Asp382His Single submitter
- p.Asp386Asn Single submitter ⚠
- p.Asp449Asn Single submitter ⚠
- p.Asp491Asn Single submitter ⚠
- p.Asp524His Single submitter ⚠
- p.Asp573Asn Single submitter ⚠
- p.Asp574Gly Single submitter ⚠
- p.Asp65Ala Single submitter ⚠
- p.Cys14Gly Single submitter ⚠
- p.Cys181Tyr Single submitter ⚠
- p.Cys299Tyr Single submitter ⚠
- p.Gln228Glu Single submitter ⚠
- p.Gln477Lys Single submitter ⚠
- p.Glu145Gln Single submitter ⚠
- p.Glu517Lys Single submitter ⚠
- p.Glu609Val Single submitter ⚠
- p.Glu641Lys Single submitter ⚠
- p.Glu70Lys Single submitter ⚠
- p.Gly118Ser Single submitter ⚠
- p.Gly265Glu Single submitter ⚠
- p.Gly381Arg Single submitter ⚠
- p.Gly396Arg Single submitter ⚠
- p.Gly614Ser Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile132Met Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile589Leu Single submitter ⚠
- p.Ile628Thr Single submitter ⚠
- p.Leu196Arg Single submitter
- p.Leu205His Single submitter ⚠
- p.Leu261Phe Single submitter
- p.Leu263Met Single submitter ⚠
- p.Leu296Ser Single submitter ⚠
- p.Leu430Gln Single submitter ⚠
- p.Leu544Arg Single submitter ⚠
- p.Lys459Glu Single submitter ⚠
- p.Met137Val Single submitter ⚠
- p.Met184Leu Single submitter ⚠
- p.Met529Leu Single submitter ⚠
- p.Met642Thr Single submitter ⚠
- p.Phe38Leu Single submitter ⚠
- p.Phe83Cys Single submitter ⚠
- p.Pro213Arg Single submitter ⚠
- p.Pro398Ser Single submitter ⚠
- p.Pro438Leu Single submitter ⚠
- p.Pro495Ala Single submitter ⚠
- p.Pro556Thr Single submitter ⚠
- p.Pro583Thr Single submitter ⚠
- p.Pro590Ser Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Ser254Phe Single submitter ⚠
- p.Ser56Cys Single submitter ⚠
- p.Ser79Ala Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr120Ile Single submitter ⚠
- p.Thr126Met Single submitter ⚠
- p.Thr88Met Single submitter ⚠
- p.Thr95Ile Single submitter ⚠
- p.Tyr182Cys Single submitter ⚠
- p.Tyr231Asp Single submitter ⚠
- p.Val130Ile Single submitter ⚠
- p.Val324Phe Single submitter ⚠
- p.Val393Leu Single submitter ⚠
- p.Val405Ala Single submitter ⚠
- p.Val591Met Single submitter ⚠
- p.Val617Ile Single submitter ⚠
- p.Val651Phe Single submitter ⚠
- p.Val75Ala Single submitter ⚠