Sugi Variant

Sugi Variant/INVS

INVS — 1107 ClinVar variants

All ClinVar germline INVS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 450 flagged for review →

67 Pathogenic · 21 Pathogenic/Likely pathogenic · 36 Likely pathogenic · 57 Conflicting · 26 Benign · 17 Benign/Likely benign · 391 Likely benign · 492 Uncertain significance

Full INVS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 450

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 20

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 328

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 328

Predictors split 102

The independent predictors disagree with each other — read with care.

All INVS variants

Pathogenic 67

Pathogenic/Likely pathogenic 21

Likely pathogenic 36

Conflicting classifications of pathogenicity 57

Benign 26

Benign/Likely benign 17

Likely benign 391

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 492

Showing the top 300 by review status; the full set is in the sitemap.