IP6K2 — 41 ClinVar variants
All ClinVar germline IP6K2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 39 Uncertain significance
Full IP6K2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IP6K2 p.Ala195Gly Uncertain significance Single submitter
- IP6K2 p.Ala374Val Uncertain significance Single submitter
- IP6K2 p.Ala57Thr Uncertain significance Single submitter
- IP6K2 p.Arg133Cys Uncertain significance Single submitter
- IP6K2 p.Arg133His Uncertain significance Single submitter
- IP6K2 p.Arg198Gln Uncertain significance Single submitter
- IP6K2 p.Arg212Cys Uncertain significance Single submitter
- IP6K2 p.Arg212His Uncertain significance Single submitter
- IP6K2 p.Arg297Trp Uncertain significance Single submitter
- IP6K2 p.Arg300Cys Uncertain significance Single submitter
- IP6K2 p.Arg325His Uncertain significance Single submitter
- IP6K2 p.Arg6Gly Uncertain significance Single submitter
- IP6K2 p.Arg73Cys Uncertain significance Single submitter
- IP6K2 p.Arg73His Uncertain significance Single submitter
- IP6K2 p.Arg73Ser Uncertain significance Single submitter
- IP6K2 p.Asn199Thr Uncertain significance Single submitter
- IP6K2 p.Asn239Thr Uncertain significance Single submitter
- IP6K2 p.Asn36Ser Uncertain significance Single submitter
- IP6K2 p.Asp231Asn Uncertain significance Single submitter
- IP6K2 p.Asp79Asn Uncertain significance Single submitter
- IP6K2 p.Cys83Ser Uncertain significance Single submitter
- IP6K2 p.Glu149Asp Uncertain significance Single submitter
- IP6K2 p.Glu322Asp Uncertain significance Single submitter
- IP6K2 p.Gly365Asp Uncertain significance Single submitter
- IP6K2 p.Gly373Ser Uncertain significance Single submitter
- IP6K2 p.Ile420Leu Uncertain significance Single submitter
- IP6K2 p.Ile98Thr Uncertain significance Single submitter
- IP6K2 p.Lys286Arg Uncertain significance Single submitter
- IP6K2 p.Met381Thr Uncertain significance Single submitter
- IP6K2 p.Pro12His Uncertain significance Single submitter
- IP6K2 p.Thr115Arg Uncertain significance Single submitter
- IP6K2 p.Thr396Ala Uncertain significance Single submitter
- IP6K2 p.Trp152Arg Uncertain significance Single submitter
- IP6K2 p.Trp152Leu Uncertain significance Single submitter
- IP6K2 p.Val343Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All IP6K2 variants
Likely benign 2
- p.Ala374Thr Single submitter
- p.Asn273His Single submitter
Uncertain significance 39
- p.Ala195Gly Single submitter ⚠
- p.Ala374Val Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg198Gln Single submitter ⚠
- p.Arg198Trp Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg297Trp Single submitter ⚠
- p.Arg300Cys Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg325His Single submitter ⚠
- p.Arg6Gly Single submitter ⚠
- p.Arg73Cys Single submitter ⚠
- p.Arg73His Single submitter ⚠
- p.Arg73Ser Single submitter ⚠
- p.Asn199Thr Single submitter ⚠
- p.Asn239Thr Single submitter ⚠
- p.Asn36Ser Single submitter ⚠
- p.Asp231Asn Single submitter ⚠
- p.Asp378Glu Single submitter ⚠
- p.Asp79Asn Single submitter ⚠
- p.Cys83Ser Single submitter ⚠
- p.Glu149Asp Single submitter ⚠
- p.Glu322Asp Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.Gly373Ser Single submitter ⚠
- p.Ile420Leu Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu33Phe Single submitter ⚠
- p.Lys286Arg Single submitter ⚠
- p.Met381Thr Single submitter ⚠
- p.Pro12His Single submitter ⚠
- p.Thr115Arg Single submitter ⚠
- p.Thr396Ala Single submitter ⚠
- p.Trp152Arg Single submitter ⚠
- p.Trp152Leu Single submitter ⚠
- p.Val343Ala Single submitter ⚠