IP6K3 — 77 ClinVar variants
All ClinVar germline IP6K3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
4 Likely benign · 73 Uncertain significance
Full IP6K3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IP6K3 p.Gly26Arg Uncertain significance Multiple submitters
- IP6K3 p.Ala124Asp Uncertain significance Single submitter
- IP6K3 p.Ala129Val Uncertain significance Single submitter
- IP6K3 p.Ala233Pro Uncertain significance Single submitter
- IP6K3 p.Ala7Thr Uncertain significance Single submitter
- IP6K3 p.Ala9Val Uncertain significance Single submitter
- IP6K3 p.Arg133Ser Uncertain significance Single submitter
- IP6K3 p.Arg185Cys Uncertain significance Single submitter
- IP6K3 p.Arg185His Uncertain significance Single submitter
- IP6K3 p.Arg195Gln Uncertain significance Single submitter
- IP6K3 p.Arg195Trp Uncertain significance Single submitter
- IP6K3 p.Arg197Gln Uncertain significance Single submitter
- IP6K3 p.Arg307Gly Uncertain significance Single submitter
- IP6K3 p.Arg307Trp Uncertain significance Single submitter
- IP6K3 p.Asn162Ser Uncertain significance Single submitter
- IP6K3 p.Asn172Ser Uncertain significance Single submitter
- IP6K3 p.Asn5Ser Uncertain significance Single submitter
- IP6K3 p.Asp120Asn Uncertain significance Single submitter
- IP6K3 p.Asp120Glu Uncertain significance Single submitter
- IP6K3 p.Asp215Asn Uncertain significance Single submitter
- IP6K3 p.Cys246Tyr Uncertain significance Single submitter
- IP6K3 p.Gln286Arg Uncertain significance Single submitter
- IP6K3 p.Gln305Glu Uncertain significance Single submitter
- IP6K3 p.Glu147Lys Uncertain significance Single submitter
- IP6K3 p.Glu189Gln Uncertain significance Single submitter
- IP6K3 p.Glu189Lys Uncertain significance Single submitter
- IP6K3 p.Glu278Lys Uncertain significance Single submitter
- IP6K3 p.Glu297Lys Uncertain significance Single submitter
- IP6K3 p.Glu36Gly Uncertain significance Single submitter
- IP6K3 p.Glu36Lys Uncertain significance Single submitter
- IP6K3 p.Gly10Arg Uncertain significance Single submitter
- IP6K3 p.Gly253Arg Uncertain significance Single submitter
- IP6K3 p.Gly291Arg Uncertain significance Single submitter
- IP6K3 p.Gly354Ser Uncertain significance Single submitter
- IP6K3 p.Gly359Ala Uncertain significance Single submitter
- IP6K3 p.His128Pro Uncertain significance Single submitter
- IP6K3 p.His210Gln Uncertain significance Single submitter
- IP6K3 p.His223Gln Uncertain significance Single submitter
- IP6K3 p.Ile329Thr Uncertain significance Single submitter
- IP6K3 p.Leu327Val Uncertain significance Single submitter
- IP6K3 p.Lys231Asn Uncertain significance Single submitter
- IP6K3 p.Met236Arg Uncertain significance Single submitter
- IP6K3 p.Met58Val Uncertain significance Single submitter
- IP6K3 p.Phe321Leu Uncertain significance Single submitter
- IP6K3 p.Pro139Arg Uncertain significance Single submitter
- IP6K3 p.Pro139Leu Uncertain significance Single submitter
- IP6K3 p.Pro148Leu Uncertain significance Single submitter
- IP6K3 p.Pro211Ser Uncertain significance Single submitter
- IP6K3 p.Pro343Ser Uncertain significance Single submitter
- IP6K3 p.Pro55Leu Uncertain significance Single submitter
- IP6K3 p.Thr122Asn Uncertain significance Single submitter
- IP6K3 p.Thr209Met Uncertain significance Single submitter
- IP6K3 p.Thr383Asn Uncertain significance Single submitter
- IP6K3 p.Thr78Ile Uncertain significance Single submitter
- IP6K3 p.Tyr330Cys Uncertain significance Single submitter
- IP6K3 p.Val166Ile Uncertain significance Single submitter
- IP6K3 p.Val16Met Uncertain significance Single submitter
- IP6K3 p.Val256Phe Uncertain significance Single submitter
- IP6K3 p.Val31Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- IP6K3 p.Arg221Gln Uncertain significance Single submitter
- IP6K3 p.Arg295Gln Uncertain significance Single submitter
- IP6K3 p.Arg295Leu Uncertain significance Single submitter
- IP6K3 p.Arg46Trp Uncertain significance Single submitter
- IP6K3 p.Cys266Arg Uncertain significance Single submitter
- IP6K3 p.Gly175Arg Uncertain significance Single submitter
- IP6K3 p.Gly224Ser Uncertain significance Single submitter
- IP6K3 p.Val312Asp Uncertain significance Single submitter
- IP6K3 p.Val71Ala Uncertain significance Single submitter
All IP6K3 variants
Likely benign 4
- p.Arg133His Single submitter
- p.Arg307Gln Single submitter
- p.Arg60Gln Single submitter
- p.Asn151Ser Single submitter
Uncertain significance 73
- p.Gly26Arg Multiple submitters ⚠
- p.Ala124Asp Single submitter ⚠
- p.Ala129Val Single submitter ⚠
- p.Ala233Pro Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg133Ser Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg195Gln Single submitter ⚠
- p.Arg195Trp Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg295Leu Single submitter ⚠
- p.Arg307Gly Single submitter ⚠
- p.Arg307Trp Single submitter ⚠
- p.Arg366Cys Single submitter
- p.Arg366His Single submitter
- p.Arg46Trp Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Asn172Ser Single submitter ⚠
- p.Asn5Ser Single submitter ⚠
- p.Asp120Asn Single submitter ⚠
- p.Asp120Glu Single submitter ⚠
- p.Asp215Asn Single submitter ⚠
- p.Asp226Tyr Single submitter
- p.Cys246Tyr Single submitter ⚠
- p.Cys266Arg Single submitter ⚠
- p.Gln286Arg Single submitter ⚠
- p.Gln305Glu Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu189Gln Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu278Lys Single submitter ⚠
- p.Glu297Lys Single submitter ⚠
- p.Glu36Gly Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly175Arg Single submitter ⚠
- p.Gly224Ser Single submitter ⚠
- p.Gly253Arg Single submitter ⚠
- p.Gly291Arg Single submitter ⚠
- p.Gly354Ser Single submitter ⚠
- p.Gly359Ala Single submitter ⚠
- p.His128Pro Single submitter ⚠
- p.His210Gln Single submitter ⚠
- p.His223Gln Single submitter ⚠
- p.Ile329Thr Single submitter ⚠
- p.Leu327Val Single submitter ⚠
- p.Lys231Asn Single submitter ⚠
- p.Met236Arg Single submitter ⚠
- p.Met58Val Single submitter ⚠
- p.Phe321Leu Single submitter ⚠
- p.Pro139Arg Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro148Leu Single submitter ⚠
- p.Pro173Thr Single submitter
- p.Pro211Ser Single submitter ⚠
- p.Pro301His Single submitter
- p.Pro343Ser Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Thr122Asn Single submitter ⚠
- p.Thr209Met Single submitter ⚠
- p.Thr383Asn Single submitter ⚠
- p.Thr78Ile Single submitter ⚠
- p.Tyr330Cys Single submitter ⚠
- p.Val166Ile Single submitter ⚠
- p.Val16Met Single submitter ⚠
- p.Val256Phe Single submitter ⚠
- p.Val312Asp Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val71Ala Single submitter ⚠