IPO11 — 122 ClinVar variants
All ClinVar germline IPO11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
8 Benign · 5 Likely benign · 109 Uncertain significance
Full IPO11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IPO11 p.Thr409Ala Uncertain significance Multiple submitters
- IPO11 p.Ala110Val Uncertain significance Single submitter
- IPO11 p.Ala332Thr Uncertain significance Single submitter
- IPO11 p.Ala452Ser Uncertain significance Single submitter
- IPO11 p.Ala636Thr Uncertain significance Single submitter
- IPO11 p.Ala814Thr Uncertain significance Single submitter
- IPO11 p.Arg143Gly Uncertain significance Single submitter
- IPO11 p.Arg146Gly Uncertain significance Single submitter
- IPO11 p.Arg219His Uncertain significance Single submitter
- IPO11 p.Arg245His Uncertain significance Single submitter
- IPO11 p.Arg254Lys Uncertain significance Single submitter
- IPO11 p.Arg532Cys Uncertain significance Single submitter
- IPO11 p.Arg783Gly Uncertain significance Single submitter
- IPO11 p.Arg91His Uncertain significance Single submitter
- IPO11 p.Asn330His Uncertain significance Single submitter
- IPO11 p.Asn4Ser Uncertain significance Single submitter
- IPO11 p.Asn677Ser Uncertain significance Single submitter
- IPO11 p.Asn872Ser Uncertain significance Single submitter
- IPO11 p.Asn97Ser Uncertain significance Single submitter
- IPO11 p.Asp259Gly Uncertain significance Single submitter
- IPO11 p.Asp387Gly Uncertain significance Single submitter
- IPO11 p.Cys366Tyr Uncertain significance Single submitter
- IPO11 p.Gln139Arg Uncertain significance Single submitter
- IPO11 p.Gln248Arg Uncertain significance Single submitter
- IPO11 p.Gln566His Uncertain significance Single submitter
- IPO11 p.Gln604His Uncertain significance Single submitter
- IPO11 p.Gln864His Uncertain significance Single submitter
- IPO11 p.Glu780Asp Uncertain significance Single submitter
- IPO11 p.Glu812Val Uncertain significance Single submitter
- IPO11 p.Glu939Gln Uncertain significance Single submitter
- IPO11 p.Glu950Gly Uncertain significance Single submitter
- IPO11 p.Gly712Val Uncertain significance Single submitter
- IPO11 p.Gly777Ser Uncertain significance Single submitter
- IPO11 p.Gly877Ser Uncertain significance Single submitter
- IPO11 p.His153Arg Uncertain significance Single submitter
- IPO11 p.His230Asp Uncertain significance Single submitter
- IPO11 p.His616Arg Uncertain significance Single submitter
- IPO11 p.Ile105Val Uncertain significance Single submitter
- IPO11 p.Ile271Val Uncertain significance Single submitter
- IPO11 p.Ile317Val Uncertain significance Single submitter
- IPO11 p.Ile628Leu Uncertain significance Single submitter
- IPO11 p.Ile688Val Uncertain significance Single submitter
- IPO11 p.Ile761Thr Uncertain significance Single submitter
- IPO11 p.Ile871Thr Uncertain significance Single submitter
- IPO11 p.Leu272Val Uncertain significance Single submitter
- IPO11 p.Leu627Val Uncertain significance Single submitter
- IPO11 p.Leu792Arg Uncertain significance Single submitter
- IPO11 p.Leu810Pro Uncertain significance Single submitter
- IPO11 p.Leu824Phe Uncertain significance Single submitter
- IPO11 p.Lys337Gln Uncertain significance Single submitter
- IPO11 p.Met515Val Uncertain significance Single submitter
- IPO11 p.Met593Ile Uncertain significance Single submitter
- IPO11 p.Met766Thr Uncertain significance Single submitter
- IPO11 p.Met813Val Uncertain significance Single submitter
- IPO11 p.Met828Ile Uncertain significance Single submitter
- IPO11 p.Met897Ile Uncertain significance Single submitter
- IPO11 p.Phe805Ile Uncertain significance Single submitter
- IPO11 p.Phe817Cys Uncertain significance Single submitter
- IPO11 p.Pro229Ala Uncertain significance Single submitter
- IPO11 p.Pro344Thr Uncertain significance Single submitter
- IPO11 p.Pro360Arg Uncertain significance Single submitter
- IPO11 p.Pro39Gln Uncertain significance Single submitter
- IPO11 p.Pro683Ser Uncertain significance Single submitter
- IPO11 p.Ser198Ala Uncertain significance Single submitter
- IPO11 p.Thr191Ile Uncertain significance Single submitter
- IPO11 p.Thr269Asn Uncertain significance Single submitter
- IPO11 p.Thr274Ser Uncertain significance Single submitter
- IPO11 p.Thr363Ala Uncertain significance Single submitter
- IPO11 p.Thr363Ile Uncertain significance Single submitter
- IPO11 p.Thr50Ile Uncertain significance Single submitter
- IPO11 p.Thr50Ser Uncertain significance Single submitter
- IPO11 p.Thr53Ala Uncertain significance Single submitter
- IPO11 p.Thr724Ala Uncertain significance Single submitter
- IPO11 p.Thr790Met Uncertain significance Single submitter
- IPO11 p.Thr962Met Uncertain significance Single submitter
- IPO11 p.Tyr171Asp Uncertain significance Single submitter
- IPO11 p.Tyr171Cys Uncertain significance Single submitter
- IPO11 p.Tyr420Cys Uncertain significance Single submitter
- IPO11 p.Tyr489Cys Uncertain significance Single submitter
- IPO11 p.Val13Met Uncertain significance Single submitter
- IPO11 p.Val227Ala Uncertain significance Single submitter
- IPO11 p.Val261Met Uncertain significance Single submitter
- IPO11 p.Val370Leu Uncertain significance Single submitter
- IPO11 p.Val427Leu Uncertain significance Single submitter
- IPO11 p.Val496Met Uncertain significance Single submitter
- IPO11 p.Val648Gly Uncertain significance Single submitter
- IPO11 p.Val746Ile Uncertain significance Single submitter
- IPO11 p.Val758Met Uncertain significance Single submitter
- IPO11 p.Val77Ile Uncertain significance Single submitter
- IPO11 p.Val9Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- IPO11 p.Arg315Leu Uncertain significance Single submitter
- IPO11 p.Arg76His Uncertain significance Single submitter
- IPO11 p.Asp279Glu Uncertain significance Single submitter
- IPO11 p.Cys521Tyr Uncertain significance Single submitter
- IPO11 p.Gln731Pro Uncertain significance Single submitter
- IPO11 p.Gly781Arg Uncertain significance Single submitter
- IPO11 p.Leu855Val Uncertain significance Single submitter
- IPO11 p.Lys334Thr Uncertain significance Single submitter
- IPO11 p.Met882Ile Uncertain significance Single submitter
- IPO11 p.Phe304Leu Uncertain significance Single submitter
- IPO11 p.Phe806Ser Uncertain significance Single submitter
- IPO11 p.Pro27Ser Uncertain significance Single submitter
- IPO11 p.Tyr725Cys Uncertain significance Single submitter
- IPO11 p.Tyr784Cys Uncertain significance Single submitter
All IPO11 variants
Benign 8
- p.Ala726= Multiple submitters
- p.Asn260Asp Multiple submitters
- p.Leu112= Multiple submitters
- p.Leu246= Multiple submitters
- p.Leu799= Multiple submitters
- c.708+10C>T Single submitter
- p.Leu800= Single submitter
- p.Phe546= Single submitter
Likely benign 5
- p.Asp172= Single submitter
- p.Ile681Val Single submitter
- p.Ser255Asn Single submitter
- p.Tyr773Cys Single submitter
- p.Gln632Arg No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 109
- p.Thr409Ala Multiple submitters ⚠
- p.Ala110Val Single submitter ⚠
- p.Ala332Thr Single submitter ⚠
- p.Ala452Ser Single submitter ⚠
- p.Ala636Thr Single submitter ⚠
- p.Ala814Thr Single submitter ⚠
- p.Arg143Gly Single submitter ⚠
- p.Arg146Gly Single submitter ⚠
- p.Arg219His Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg254Lys Single submitter ⚠
- p.Arg315Leu Single submitter ⚠
- p.Arg532Cys Single submitter ⚠
- p.Arg76His Single submitter ⚠
- p.Arg783Gly Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn330His Single submitter ⚠
- p.Asn4Ser Single submitter ⚠
- p.Asn677Ser Single submitter ⚠
- p.Asn872Ser Single submitter ⚠
- p.Asn97Ser Single submitter ⚠
- p.Asp259Gly Single submitter ⚠
- p.Asp279Glu Single submitter ⚠
- p.Asp387Gly Single submitter ⚠
- p.Cys366Tyr Single submitter ⚠
- p.Cys521Tyr Single submitter ⚠
- p.Gln139Arg Single submitter ⚠
- p.Gln248Arg Single submitter ⚠
- p.Gln566His Single submitter ⚠
- p.Gln604His Single submitter ⚠
- p.Gln731Pro Single submitter ⚠
- p.Gln864His Single submitter ⚠
- p.Glu780Asp Single submitter ⚠
- p.Glu812Val Single submitter ⚠
- p.Glu939Gln Single submitter ⚠
- p.Glu950Gly Single submitter ⚠
- p.Gly712Val Single submitter ⚠
- p.Gly777Ser Single submitter ⚠
- p.Gly781Arg Single submitter ⚠
- p.Gly877Ser Single submitter ⚠
- p.His153Arg Single submitter ⚠
- p.His230Asp Single submitter ⚠
- p.His616Arg Single submitter ⚠
- p.His629Arg Single submitter
- p.Ile105Val Single submitter ⚠
- p.Ile271Val Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Ile628Leu Single submitter ⚠
- p.Ile688Val Single submitter ⚠
- p.Ile761Thr Single submitter ⚠
- p.Ile871Thr Single submitter ⚠
- p.Leu272Val Single submitter ⚠
- p.Leu627Val Single submitter ⚠
- p.Leu792Arg Single submitter ⚠
- p.Leu810Pro Single submitter ⚠
- p.Leu824Phe Single submitter ⚠
- p.Leu855Val Single submitter ⚠
- p.Lys334Thr Single submitter ⚠
- p.Lys337Gln Single submitter ⚠
- p.Met515Val Single submitter ⚠
- p.Met593Ile Single submitter ⚠
- p.Met766Thr Single submitter ⚠
- p.Met813Val Single submitter ⚠
- p.Met828Ile Single submitter ⚠
- p.Met882Ile Single submitter ⚠
- p.Met882Val Single submitter
- p.Met897Ile Single submitter ⚠
- p.Phe304Leu Single submitter ⚠
- p.Phe805Ile Single submitter ⚠
- p.Phe806Ser Single submitter ⚠
- p.Phe817Cys Single submitter ⚠
- p.Pro229Ala Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro344Thr Single submitter ⚠
- p.Pro360Arg Single submitter ⚠
- p.Pro39Gln Single submitter ⚠
- p.Pro643Arg Single submitter
- p.Pro683Ser Single submitter ⚠
- p.Ser198Ala Single submitter ⚠
- p.Thr155Ser Single submitter
- p.Thr191Ile Single submitter ⚠
- p.Thr269Asn Single submitter ⚠
- p.Thr274Ser Single submitter ⚠
- p.Thr363Ala Single submitter ⚠
- p.Thr363Ile Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Thr50Ser Single submitter ⚠
- p.Thr53Ala Single submitter ⚠
- p.Thr724Ala Single submitter ⚠
- p.Thr790Met Single submitter ⚠
- p.Thr962Met Single submitter ⚠
- p.Tyr171Asp Single submitter ⚠
- p.Tyr171Cys Single submitter ⚠
- p.Tyr420Cys Single submitter ⚠
- p.Tyr489Cys Single submitter ⚠
- p.Tyr725Cys Single submitter ⚠
- p.Tyr784Cys Single submitter ⚠
- p.Val13Met Single submitter ⚠
- p.Val227Ala Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val370Leu Single submitter ⚠
- p.Val427Leu Single submitter ⚠
- p.Val496Met Single submitter ⚠
- p.Val648Gly Single submitter ⚠
- p.Val746Ile Single submitter ⚠
- p.Val758Met Single submitter ⚠
- p.Val77Ile Single submitter ⚠
- p.Val9Ile Single submitter ⚠
- c.-6-1400_138+1704dup No assertion criteria congenital hydrocephalus