IPO5 — 7 ClinVar variants
All ClinVar germline IPO5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
2 Benign · 2 Likely benign · 3 Uncertain significance
Full IPO5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All IPO5 variants
Likely benign 2
- c.1716+39_1716+44dup Single submitter
- c.1716+40_1716+44dup Single submitter
Uncertain significance 3
- p.Gln8His Single submitter ⚠
- p.Lys506Arg Single submitter ⚠
- p.Lys775Met Single submitter