IPO7 — 82 ClinVar variants
All ClinVar germline IPO7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
1 Likely benign · 81 Uncertain significance
Full IPO7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IPO7 p.Ala363Gly Uncertain significance Single submitter
- IPO7 p.Ala74Ser Uncertain significance Single submitter
- IPO7 p.Ala764Gly Uncertain significance Single submitter
- IPO7 p.Ala786Gly Uncertain significance Single submitter
- IPO7 p.Ala843Ser Uncertain significance Single submitter
- IPO7 p.Ala923Gly Uncertain significance Single submitter
- IPO7 p.Ala979Thr Uncertain significance Single submitter
- IPO7 p.Arg125His Uncertain significance Single submitter
- IPO7 p.Arg167Gln Uncertain significance Single submitter
- IPO7 p.Arg768Ile Uncertain significance Single submitter
- IPO7 p.Arg779Gln Uncertain significance Single submitter
- IPO7 p.Arg92Gln Uncertain significance Single submitter
- IPO7 p.Asn527Ser Uncertain significance Single submitter
- IPO7 p.Asn803Ser Uncertain significance Single submitter
- IPO7 p.Asp425Gly Uncertain significance Single submitter
- IPO7 p.Asp597Gly Uncertain significance Single submitter
- IPO7 p.Asp826Gly Uncertain significance Single submitter
- IPO7 p.Asp833Tyr Uncertain significance Single submitter
- IPO7 p.Asp890Glu Uncertain significance Single submitter
- IPO7 p.Gln246His Uncertain significance Single submitter
- IPO7 p.Gln670Pro Uncertain significance Single submitter
- IPO7 p.Gln860His Uncertain significance Single submitter
- IPO7 p.Glu160Asp Uncertain significance Single submitter
- IPO7 p.Glu485Asp Uncertain significance Single submitter
- IPO7 p.Glu767Gly Uncertain significance Single submitter
- IPO7 p.Gly470Asp Uncertain significance Single submitter
- IPO7 p.Gly595Glu Uncertain significance Single submitter
- IPO7 p.Gly728Arg Uncertain significance Single submitter
- IPO7 p.Gly76Val Uncertain significance Single submitter
- IPO7 p.Gly983Arg Uncertain significance Single submitter
- IPO7 p.Gly983Ser Uncertain significance Single submitter
- IPO7 p.His882Arg Uncertain significance Single submitter
- IPO7 p.His982Asp Uncertain significance Single submitter
- IPO7 p.Ile267Val Uncertain significance Single submitter
- IPO7 p.Ile506Thr Uncertain significance Single submitter
- IPO7 p.Ile550Val Uncertain significance Single submitter
- IPO7 p.Ile655Val Uncertain significance Single submitter
- IPO7 p.Ile745Val Uncertain significance Single submitter
- IPO7 p.Ile95Val Uncertain significance Single submitter
- IPO7 p.Ile965Ser Uncertain significance Single submitter
- IPO7 p.Leu337Val Uncertain significance Single submitter
- IPO7 p.Leu342Val Uncertain significance Single submitter
- IPO7 p.Leu637Ser Uncertain significance Single submitter
- IPO7 p.Lys626Gln Uncertain significance Single submitter
- IPO7 p.Lys626Glu Uncertain significance Single submitter
- IPO7 p.Met174Val Uncertain significance Single submitter
- IPO7 p.Met671Leu Uncertain significance Single submitter
- IPO7 p.Pro422Ala Uncertain significance Single submitter
- IPO7 p.Pro80Leu Uncertain significance Single submitter
- IPO7 p.Ser142Asn Uncertain significance Single submitter
- IPO7 p.Ser32Ala Uncertain significance Single submitter
- IPO7 p.Ser402Asn Uncertain significance Single submitter
- IPO7 p.Ser438Cys Uncertain significance Single submitter
- IPO7 p.Ser466Asn Uncertain significance Single submitter
- IPO7 p.Thr226Arg Uncertain significance Single submitter
- IPO7 p.Thr574Ile Uncertain significance Single submitter
- IPO7 p.Thr73Ile Uncertain significance Single submitter
- IPO7 p.Thr82Ser Uncertain significance Single submitter
- IPO7 p.Val353Ile Uncertain significance Single submitter
- IPO7 p.Val621Ile Uncertain significance Single submitter
- IPO7 p.Val853Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- IPO7 p.Arg805Cys Uncertain significance Single submitter
- IPO7 p.Arg972Cys Uncertain significance Single submitter
- IPO7 p.Asp929Val Uncertain significance Single submitter
- IPO7 p.Cys359Ser Uncertain significance Single submitter
- IPO7 p.Gln683Arg Uncertain significance Single submitter
- IPO7 p.Leu831Phe Uncertain significance Single submitter
- IPO7 p.Lys410Asn Uncertain significance Single submitter
- IPO7 p.Met317Arg Uncertain significance Single submitter
- IPO7 p.Met63Ile Uncertain significance Single submitter
- IPO7 p.Phe462Leu Uncertain significance Single submitter
- IPO7 p.Pro422Arg Uncertain significance Single submitter
- IPO7 p.Ser467Gly Uncertain significance Single submitter
- IPO7 p.Thr391Ala Uncertain significance Single submitter
- IPO7 p.Tyr136Asn Uncertain significance Single submitter
- IPO7 p.Tyr136Cys Uncertain significance Single submitter
- IPO7 p.Val108Leu Uncertain significance Single submitter
- IPO7 p.Val96Leu Uncertain significance Single submitter
All IPO7 variants
Likely benign 1
- p.Arg107= Single submitter
Uncertain significance 81
- p.Ala363Gly Single submitter ⚠
- p.Ala74Ser Single submitter ⚠
- p.Ala764Gly Single submitter ⚠
- p.Ala786Gly Single submitter ⚠
- p.Ala843Ser Single submitter ⚠
- p.Ala923Gly Single submitter ⚠
- p.Ala979Thr Single submitter ⚠
- p.Arg125His Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg184Cys Single submitter
- p.Arg768Ile Single submitter ⚠
- p.Arg779Gln Single submitter ⚠
- p.Arg805Cys Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Arg972Cys Single submitter ⚠
- p.Asn527Ser Single submitter ⚠
- p.Asn803Ser Single submitter ⚠
- p.Asp425Gly Single submitter ⚠
- p.Asp597Gly Single submitter ⚠
- p.Asp826Gly Single submitter ⚠
- p.Asp833Tyr Single submitter ⚠
- p.Asp890Glu Single submitter ⚠
- p.Asp929Val Single submitter ⚠
- p.Cys359Ser Single submitter ⚠
- p.Gln246His Single submitter ⚠
- p.Gln670Pro Single submitter ⚠
- p.Gln683Arg Single submitter ⚠
- p.Gln860His Single submitter ⚠
- p.Glu160Asp Single submitter ⚠
- p.Glu485Asp Single submitter ⚠
- p.Glu767Gly Single submitter ⚠
- p.Gly470Asp Single submitter ⚠
- p.Gly595Glu Single submitter ⚠
- p.Gly728Arg Single submitter ⚠
- p.Gly76Val Single submitter ⚠
- p.Gly983Arg Single submitter ⚠
- p.Gly983Ser Single submitter ⚠
- p.His882Arg Single submitter ⚠
- p.His982Asp Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile506Thr Single submitter ⚠
- p.Ile550Val Single submitter ⚠
- p.Ile655Val Single submitter ⚠
- p.Ile745Val Single submitter ⚠
- p.Ile95Val Single submitter ⚠
- p.Ile965Ser Single submitter ⚠
- p.Leu337Val Single submitter ⚠
- p.Leu342Val Single submitter ⚠
- p.Leu637Ser Single submitter ⚠
- p.Leu831Phe Single submitter ⚠
- p.Lys410Asn Single submitter ⚠
- p.Lys626Gln Single submitter ⚠
- p.Lys626Glu Single submitter ⚠
- p.Met174Val Single submitter ⚠
- p.Met317Arg Single submitter ⚠
- p.Met456Leu Single submitter
- p.Met63Ile Single submitter ⚠
- p.Met671Leu Single submitter ⚠
- p.Phe462Leu Single submitter ⚠
- p.Pro422Ala Single submitter ⚠
- p.Pro422Arg Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser142Asn Single submitter ⚠
- p.Ser32Ala Single submitter ⚠
- p.Ser402Asn Single submitter ⚠
- p.Ser438Cys Single submitter ⚠
- p.Ser466Asn Single submitter ⚠
- p.Ser467Gly Single submitter ⚠
- p.Thr226Arg Single submitter ⚠
- p.Thr390Ile Single submitter
- p.Thr391Ala Single submitter ⚠
- p.Thr574Ile Single submitter ⚠
- p.Thr73Ile Single submitter ⚠
- p.Thr82Ser Single submitter ⚠
- p.Tyr136Asn Single submitter ⚠
- p.Tyr136Cys Single submitter ⚠
- p.Val108Leu Single submitter ⚠
- p.Val353Ile Single submitter ⚠
- p.Val621Ile Single submitter ⚠
- p.Val853Ile Single submitter ⚠
- p.Val96Leu Single submitter ⚠