Sugi Variant

Sugi Variant/IPO8

IPO8 — 185 ClinVar variants

All ClinVar germline IPO8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →

16 Pathogenic · 3 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 2 Conflicting · 5 Benign · 4 Benign/Likely benign · 32 Likely benign · 113 Uncertain significance

Full IPO8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 108

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 83

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All IPO8 variants

Pathogenic 16

Pathogenic/Likely pathogenic 3

Likely pathogenic 10

Conflicting classifications of pathogenicity 2

Benign 5

Benign/Likely benign 4

Likely benign 32

Uncertain significance 113