IPO9 — 94 ClinVar variants
All ClinVar germline IPO9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
1 Benign · 1 Likely benign · 92 Uncertain significance
Full IPO9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IPO9 p.Ala10Val Uncertain significance Single submitter
- IPO9 p.Ala166Pro Uncertain significance Single submitter
- IPO9 p.Ala342Gly Uncertain significance Single submitter
- IPO9 p.Ala418Gly Uncertain significance Single submitter
- IPO9 p.Ala425Thr Uncertain significance Single submitter
- IPO9 p.Ala498Ser Uncertain significance Single submitter
- IPO9 p.Ala599Thr Uncertain significance Single submitter
- IPO9 p.Ala638Gly Uncertain significance Single submitter
- IPO9 p.Ala668Val Uncertain significance Single submitter
- IPO9 p.Ala6Thr Uncertain significance Single submitter
- IPO9 p.Ala70Ser Uncertain significance Single submitter
- IPO9 p.Ala934Thr Uncertain significance Single submitter
- IPO9 p.Arg175Leu Uncertain significance Single submitter
- IPO9 p.Arg754His Uncertain significance Single submitter
- IPO9 p.Arg754Leu Uncertain significance Single submitter
- IPO9 p.Arg877Gln Uncertain significance Single submitter
- IPO9 p.Arg882Cys Uncertain significance Single submitter
- IPO9 p.Arg898Cys Uncertain significance Single submitter
- IPO9 p.Arg898His Uncertain significance Single submitter
- IPO9 p.Arg907His Uncertain significance Single submitter
- IPO9 p.Asn311Ser Uncertain significance Single submitter
- IPO9 p.Asn381Ile Uncertain significance Single submitter
- IPO9 p.Asn738Ser Uncertain significance Single submitter
- IPO9 p.Asn904Ser Uncertain significance Single submitter
- IPO9 p.Asn927Ser Uncertain significance Single submitter
- IPO9 p.Gln727Glu Uncertain significance Single submitter
- IPO9 p.Glu315Val Uncertain significance Single submitter
- IPO9 p.Glu596Lys Uncertain significance Single submitter
- IPO9 p.Glu886Val Uncertain significance Single submitter
- IPO9 p.Gly12Arg Uncertain significance Single submitter
- IPO9 p.His526Gln Uncertain significance Single submitter
- IPO9 p.Ile636Thr Uncertain significance Single submitter
- IPO9 p.Ile911Phe Uncertain significance Single submitter
- IPO9 p.Leu13Met Uncertain significance Single submitter
- IPO9 p.Leu343Ile Uncertain significance Single submitter
- IPO9 p.Leu488Phe Uncertain significance Single submitter
- IPO9 p.Leu582Arg Uncertain significance Single submitter
- IPO9 p.Leu974Ile Uncertain significance Single submitter
- IPO9 p.Met802Leu Uncertain significance Single submitter
- IPO9 p.Pro319Ser Uncertain significance Single submitter
- IPO9 p.Pro753His Uncertain significance Single submitter
- IPO9 p.Pro819Thr Uncertain significance Single submitter
- IPO9 p.Pro905Ala Uncertain significance Single submitter
- IPO9 p.Ser11Phe Uncertain significance Single submitter
- IPO9 p.Ser209Phe Uncertain significance Single submitter
- IPO9 p.Ser347Asn Uncertain significance Single submitter
- IPO9 p.Ser523Gly Uncertain significance Single submitter
- IPO9 p.Ser532Leu Uncertain significance Single submitter
- IPO9 p.Ser532Thr Uncertain significance Single submitter
- IPO9 p.Ser563Gly Uncertain significance Single submitter
- IPO9 p.Ser576Asn Uncertain significance Single submitter
- IPO9 p.Ser576Thr Uncertain significance Single submitter
- IPO9 p.Thr259Ala Uncertain significance Single submitter
- IPO9 p.Thr352Ile Uncertain significance Single submitter
- IPO9 p.Thr393Lys Uncertain significance Single submitter
- IPO9 p.Thr704Ile Uncertain significance Single submitter
- IPO9 p.Thr755Ile Uncertain significance Single submitter
- IPO9 p.Thr815Ala Uncertain significance Single submitter
- IPO9 p.Val240Met Uncertain significance Single submitter
- IPO9 p.Val268Ile Uncertain significance Single submitter
- IPO9 p.Val26Leu Uncertain significance Single submitter
- IPO9 p.Val294Gly Uncertain significance Single submitter
- IPO9 p.Val316Glu Uncertain significance Single submitter
- IPO9 p.Val333Ile Uncertain significance Single submitter
- IPO9 p.Val590Ile Uncertain significance Single submitter
- IPO9 p.Val621Ile Uncertain significance Single submitter
- IPO9 p.Val928Ile Uncertain significance Single submitter
-
IPO9 p.Glu715Gly
Uncertain significance
No assertion criteria
IPO9-related condition
Predictors split 12
The independent predictors disagree with each other — read with care.
- IPO9 p.Ala131Val Uncertain significance Single submitter
- IPO9 p.Arg427Gly Uncertain significance Single submitter
- IPO9 p.Arg787Leu Uncertain significance Single submitter
- IPO9 p.Asp179Glu Uncertain significance Single submitter
- IPO9 p.Asp752His Uncertain significance Single submitter
- IPO9 p.Asp993His Uncertain significance Single submitter
- IPO9 p.Cys545Ser Uncertain significance Single submitter
- IPO9 p.Glu958Lys Uncertain significance Single submitter
- IPO9 p.Ile32Ser Uncertain significance Single submitter
- IPO9 p.Lys348Ile Uncertain significance Single submitter
- IPO9 p.Phe96Cys Uncertain significance Single submitter
- IPO9 p.Tyr851Cys Uncertain significance Single submitter
All IPO9 variants
Benign 1
- p.Gln558= Multiple submitters
Likely benign 1
- p.Ser943Asn Single submitter
Uncertain significance 92
- p.Ala10Val Single submitter ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala166Pro Single submitter ⚠
- p.Ala342Gly Single submitter ⚠
- p.Ala418Gly Single submitter ⚠
- p.Ala425Thr Single submitter ⚠
- p.Ala498Ser Single submitter ⚠
- p.Ala508Asp Single submitter
- p.Ala599Thr Single submitter ⚠
- p.Ala638Gly Single submitter ⚠
- p.Ala668Val Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Ala70Ser Single submitter ⚠
- p.Ala934Thr Single submitter ⚠
- p.Arg175Leu Single submitter ⚠
- p.Arg427Gly Single submitter ⚠
- p.Arg754His Single submitter ⚠
- p.Arg754Leu Single submitter ⚠
- p.Arg765His Single submitter
- p.Arg787Leu Single submitter ⚠
- p.Arg877Gln Single submitter ⚠
- p.Arg882Cys Single submitter ⚠
- p.Arg898Cys Single submitter ⚠
- p.Arg898His Single submitter ⚠
- p.Arg907His Single submitter ⚠
- p.Asn311Ser Single submitter ⚠
- p.Asn381Ile Single submitter ⚠
- p.Asn738Ser Single submitter ⚠
- p.Asn904Ser Single submitter ⚠
- p.Asn927Ser Single submitter ⚠
- p.Asp179Glu Single submitter ⚠
- p.Asp752His Single submitter ⚠
- p.Asp993His Single submitter ⚠
- p.Cys545Ser Single submitter ⚠
- p.Gln727Glu Single submitter ⚠
- p.Glu315Val Single submitter ⚠
- p.Glu372Lys Single submitter
- p.Glu596Lys Single submitter ⚠
- p.Glu886Val Single submitter ⚠
- p.Glu930Asp Single submitter
- p.Glu958Lys Single submitter ⚠
- p.Glu985Lys Single submitter
- p.Gly12Arg Single submitter ⚠
- p.Gly257Asp Single submitter
- p.His137Arg Single submitter
- p.His341Arg Single submitter
- p.His526Gln Single submitter ⚠
- p.His811Arg Single submitter
- p.Ile32Ser Single submitter ⚠
- p.Ile636Thr Single submitter ⚠
- p.Ile911Phe Single submitter ⚠
- p.Leu13Met Single submitter ⚠
- p.Leu343Ile Single submitter ⚠
- p.Leu488Phe Single submitter ⚠
- p.Leu582Arg Single submitter ⚠
- p.Leu974Ile Single submitter ⚠
- p.Lys348Ile Single submitter ⚠
- p.Met368Val Single submitter
- p.Met802Leu Single submitter ⚠
- p.Phe96Cys Single submitter ⚠
- p.Pro319Ser Single submitter ⚠
- p.Pro753His Single submitter ⚠
- p.Pro819Thr Single submitter ⚠
- p.Pro905Ala Single submitter ⚠
- p.Pro912Ala Single submitter
- p.Ser11Phe Single submitter ⚠
- p.Ser209Phe Single submitter ⚠
- p.Ser347Asn Single submitter ⚠
- p.Ser523Gly Single submitter ⚠
- p.Ser532Leu Single submitter ⚠
- p.Ser532Thr Single submitter ⚠
- p.Ser563Gly Single submitter ⚠
- p.Ser576Asn Single submitter ⚠
- p.Ser576Thr Single submitter ⚠
- p.Thr259Ala Single submitter ⚠
- p.Thr352Ile Single submitter ⚠
- p.Thr393Lys Single submitter ⚠
- p.Thr704Ile Single submitter ⚠
- p.Thr755Ile Single submitter ⚠
- p.Thr815Ala Single submitter ⚠
- p.Tyr851Cys Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val268Ile Single submitter ⚠
- p.Val26Leu Single submitter ⚠
- p.Val294Gly Single submitter ⚠
- p.Val316Glu Single submitter ⚠
- p.Val333Ile Single submitter ⚠
- p.Val522Ala Single submitter
- p.Val590Ile Single submitter ⚠
- p.Val621Ile Single submitter ⚠
- p.Val928Ile Single submitter ⚠
- p.Glu715Gly No assertion criteria IPO9-related condition ⚠