IPP — 80 ClinVar variants
All ClinVar germline IPP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
1 Likely benign · 79 Uncertain significance
Full IPP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IPP p.Ala57Ser Uncertain significance Single submitter
- IPP p.Arg283Trp Uncertain significance Single submitter
-
IPP p.Arg333Gln
Uncertain significance
Single submitter
IPP-related disorder
- IPP p.Arg380Cys Uncertain significance Single submitter
- IPP p.Arg380His Uncertain significance Single submitter
- IPP p.Arg409Leu Uncertain significance Single submitter
- IPP p.Arg427His Uncertain significance Single submitter
- IPP p.Arg427Pro Uncertain significance Single submitter
- IPP p.Arg453His Uncertain significance Single submitter
- IPP p.Arg464Cys Uncertain significance Single submitter
- IPP p.Arg52Trp Uncertain significance Single submitter
- IPP p.Asn484Asp Uncertain significance Single submitter
- IPP p.Asp11His Uncertain significance Single submitter
- IPP p.Asp413Asn Uncertain significance Single submitter
- IPP p.Asp498Asn Uncertain significance Single submitter
- IPP p.Cys263Tyr Uncertain significance Single submitter
- IPP p.Gln21Arg Uncertain significance Single submitter
- IPP p.Gln21Pro Uncertain significance Single submitter
- IPP p.Glu156Lys Uncertain significance Single submitter
- IPP p.Glu258Asp Uncertain significance Single submitter
- IPP p.Glu268Gln Uncertain significance Single submitter
- IPP p.Glu568Gly Uncertain significance Single submitter
-
IPP p.Gly294Asp
Uncertain significance
Single submitter
IPP-related disorder
- IPP p.Gly342Arg Uncertain significance Single submitter
- IPP p.Gly390Arg Uncertain significance Single submitter
- IPP p.Gly44Glu Uncertain significance Single submitter
- IPP p.Gly580Asp Uncertain significance Single submitter
- IPP p.His218Tyr Uncertain significance Single submitter
- IPP p.His330Arg Uncertain significance Single submitter
- IPP p.His35Tyr Uncertain significance Single submitter
- IPP p.His51Pro Uncertain significance Single submitter
- IPP p.His562Tyr Uncertain significance Single submitter
- IPP p.Ile240Met Uncertain significance Single submitter
- IPP p.Leu202Ser Uncertain significance Single submitter
- IPP p.Leu22Ile Uncertain significance Single submitter
- IPP p.Leu255Ile Uncertain significance Single submitter
- IPP p.Leu395Met Uncertain significance Single submitter
- IPP p.Leu534Phe Uncertain significance Single submitter
- IPP p.Lys217Arg Uncertain significance Single submitter
- IPP p.Lys270Gln Uncertain significance Single submitter
- IPP p.Phe228Cys Uncertain significance Single submitter
- IPP p.Phe246Tyr Uncertain significance Single submitter
- IPP p.Pro467Leu Uncertain significance Single submitter
- IPP p.Pro79Ser Uncertain significance Single submitter
- IPP p.Pro79Thr Uncertain significance Single submitter
- IPP p.Ser265Thr Uncertain significance Single submitter
- IPP p.Ser327Phe Uncertain significance Single submitter
- IPP p.Trp513Arg Uncertain significance Single submitter
- IPP p.Tyr559Cys Uncertain significance Single submitter
- IPP p.Val200Gly Uncertain significance Single submitter
- IPP p.Val419Ala Uncertain significance Single submitter
- IPP p.Val528Phe Uncertain significance Single submitter
- IPP p.Val581Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- IPP p.Ala203Gly Uncertain significance Single submitter
- IPP p.Ala374Val Uncertain significance Single submitter
- IPP p.Ala476Val Uncertain significance Single submitter
- IPP p.Arg298Gln Uncertain significance Single submitter
- IPP p.Arg298Trp Uncertain significance Single submitter
- IPP p.Arg576His Uncertain significance Single submitter
- IPP p.Gly335Arg Uncertain significance Single submitter
- IPP p.Ile407Thr Uncertain significance Single submitter
- IPP p.Leu223Val Uncertain significance Single submitter
- IPP p.Leu468Phe Uncertain significance Single submitter
- IPP p.Lys180Glu Uncertain significance Single submitter
- IPP p.Met471Val Uncertain significance Single submitter
- IPP p.Met519Thr Uncertain significance Single submitter
- IPP p.Pro79Leu Uncertain significance Single submitter
- IPP p.Ser375Leu Uncertain significance Single submitter
- IPP p.Tyr296His Uncertain significance Single submitter
- IPP p.Tyr322Asp Uncertain significance Single submitter
- IPP p.Tyr440Cys Uncertain significance Single submitter
- IPP p.Tyr536Cys Uncertain significance Single submitter
All IPP variants
Likely benign 1
- p.Thr179= Single submitter
Uncertain significance 79
- p.Ala203Gly Single submitter ⚠
- p.Ala204Val Single submitter
- p.Ala374Val Single submitter ⚠
- p.Ala476Val Single submitter ⚠
- p.Ala524Val Single submitter
- p.Ala57Ser Single submitter ⚠
- p.Arg283Trp Single submitter ⚠
- p.Arg298Gln Single submitter ⚠
- p.Arg298Trp Single submitter ⚠
- p.Arg333Gln Single submitter IPP-related disorder ⚠
- p.Arg380Cys Single submitter ⚠
- p.Arg380His Single submitter ⚠
- p.Arg409Leu Single submitter ⚠
- p.Arg427His Single submitter ⚠
- p.Arg427Pro Single submitter ⚠
- p.Arg453His Single submitter ⚠
- p.Arg464Cys Single submitter ⚠
- p.Arg52Trp Single submitter ⚠
- p.Arg576His Single submitter ⚠
- p.Asn484Asp Single submitter ⚠
- p.Asp11His Single submitter ⚠
- p.Asp413Asn Single submitter ⚠
- p.Asp498Asn Single submitter ⚠
- p.Cys263Tyr Single submitter ⚠
- p.Gln108Arg Single submitter
- p.Gln182His Single submitter
- p.Gln21Arg Single submitter ⚠
- p.Gln21Pro Single submitter ⚠
- p.Glu121Gly Single submitter
- p.Glu156Lys Single submitter ⚠
- p.Glu221Lys Single submitter
- p.Glu258Asp Single submitter ⚠
- p.Glu268Gln Single submitter ⚠
- p.Glu568Gly Single submitter ⚠
- p.Gly294Asp Single submitter IPP-related disorder ⚠
- p.Gly335Arg Single submitter ⚠
- p.Gly342Arg Single submitter ⚠
- p.Gly390Arg Single submitter ⚠
- p.Gly44Glu Single submitter ⚠
- p.Gly580Asp Single submitter ⚠
- p.His218Tyr Single submitter ⚠
- p.His330Arg Single submitter ⚠
- p.His35Tyr Single submitter ⚠
- p.His51Pro Single submitter ⚠
- p.His562Tyr Single submitter ⚠
- p.Ile240Met Single submitter ⚠
- p.Ile407Thr Single submitter ⚠
- p.Leu202Ser Single submitter ⚠
- p.Leu223Val Single submitter ⚠
- p.Leu22Ile Single submitter ⚠
- p.Leu255Ile Single submitter ⚠
- p.Leu395Met Single submitter ⚠
- p.Leu468Phe Single submitter ⚠
- p.Leu534Phe Single submitter ⚠
- p.Lys180Glu Single submitter ⚠
- p.Lys217Arg Single submitter ⚠
- p.Lys270Gln Single submitter ⚠
- p.Met471Val Single submitter ⚠
- p.Met519Thr Single submitter ⚠
- p.Phe228Cys Single submitter ⚠
- p.Phe246Tyr Single submitter ⚠
- p.Pro467Leu Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Pro79Thr Single submitter ⚠
- p.Ser265Thr Single submitter ⚠
- p.Ser327Phe Single submitter ⚠
- p.Ser375Leu Single submitter ⚠
- p.Trp513Arg Single submitter ⚠
- p.Tyr296His Single submitter ⚠
- p.Tyr322Asp Single submitter ⚠
- p.Tyr440Cys Single submitter ⚠
- p.Tyr536Cys Single submitter ⚠
- p.Tyr559Cys Single submitter ⚠
- p.Val100Ala Single submitter
- p.Val200Gly Single submitter ⚠
- p.Val419Ala Single submitter ⚠
- p.Val528Phe Single submitter ⚠
- p.Val581Ile Single submitter ⚠