Sugi Variant

Sugi Variant/IQCB1

IQCB1 — 611 ClinVar variants

All ClinVar germline IQCB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 237 flagged for review →

46 Pathogenic · 7 Pathogenic/Likely pathogenic · 39 Likely pathogenic · 26 Conflicting · 50 Benign · 11 Benign/Likely benign · 161 Likely benign · 271 Uncertain significance

Full IQCB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 237

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 10

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 190

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 190

Predictors split 37

The independent predictors disagree with each other — read with care.

All IQCB1 variants

Pathogenic 46

Pathogenic/Likely pathogenic 7

Likely pathogenic 39

Conflicting classifications of pathogenicity 26

Benign 50

Benign/Likely benign 11

Likely benign 161

Uncertain significance 271