IQCD — 10 ClinVar variants
All ClinVar germline IQCD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full IQCD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IQCD p.Ala205Val Uncertain significance Single submitter
- IQCD p.Arg130His Uncertain significance Single submitter
- IQCD p.Asn221Asp Uncertain significance Single submitter
- IQCD p.Asn221Ser Uncertain significance Single submitter
- IQCD p.Asp214Asn Uncertain significance Single submitter
- IQCD p.Ile47Thr Uncertain significance Single submitter
- IQCD p.Met400Val Uncertain significance Single submitter
- IQCD p.Phe376Tyr Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All IQCD variants
Uncertain significance 10
- p.Ala205Val Single submitter ⚠
- p.Arg130His Single submitter ⚠
- p.Arg191His Single submitter ⚠
- p.Asn221Asp Single submitter ⚠
- p.Asn221Ser Single submitter ⚠
- p.Asp214Asn Single submitter ⚠
- p.Ile47Thr Single submitter ⚠
- p.Ile60Thr Single submitter ⚠
- p.Met400Val Single submitter ⚠
- p.Phe376Tyr Single submitter ⚠